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The Anti-osteoporosis Effects of Cassia tora L. Seed Ethanol Extract in Ovariectomixed Rats  

Lee, Mu-Jin (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine)
An, Byeong-Kwan (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine)
Jung, Ho-Kyung (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine)
Lee, Ki-Ho (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine)
Kim, A-Hyeon (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine)
Lee, Hyun-Joo (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine)
Jang, Ji-Hun (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine)
Sim, Mi-Ok (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine)
Kim, Tae-Muk (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine)
Kim, Min-Suk (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine)
Seong, Tea-Gyeong (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine)
Woo, Kyeong-Wan (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine)
Cho, Jung-Hee (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine)
Kim, Jong-Choon (College of Veterinary Medicine BK21 Plus Project Team, Chonnam National University)
Cho, Hyun-Woo (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine)
Publication Information
Korean Journal of Pharmacognosy / v.47, no.4, 2016 , pp. 333-342 More about this Journal
Abstract
In our study, osteoporosis was induced by ovariectomized in female rats, and the prevention and treatment efficacy of the climacteric disease the postmenopausal type I pattern was examined by using the experimental substance Cassia tora (CT) ethanol extracts. Female rats were either sham-operated (sham; n=5) or surgically ovariectomized (OVX; five animals per group) and then administered to OVX control, raloxifene hydrochloride (RLX) 1 mg/kg/day, or CT (20 and 200 mg/kg/day) for 12 weeks. Serum osteocalcin and creatinine concentration were significantly lower in the CT 200 mg/kg/day group compared with the OVX control group. Serum progesterone concentration was significantly higher in the CT 200 mg/kg/day group compared with the OVX control group. Reduction grade of the trabecular bone decreased in the RLX 1 and CT 200 mg/kg/day group compared with that of the OVX control group. In conclusion, CT 200 mg/kg/day may have inhibitory effects on osteoporosis in OVX rats.
Keywords
Cassia tora L.; Ovariectomized; Osteocalcin; Progesterone; Creatinine;
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Times Cited By KSCI : 9  (Citation Analysis)
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