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Active Systemic Anaphylaxis Test of Purified Bee Venom(Apis mellifera L.)  

Han, Sang Mi (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Administration)
Hong, In Phyo (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Administration)
Woo, Soon Ok (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Administration)
Kim, Se Gun (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Administration)
Jang, Hye Ri (Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Administration)
Park, Kyun Kyu (School of Medicine Catholic University of Daegu)
Chang, Young Chae (School of Medicine Catholic University of Daegu)
Publication Information
Korean Journal of Pharmacognosy / v.46, no.3, 2015 , pp. 203-207 More about this Journal
Abstract
This study was performed to examine the antigenic potential of purified bee venom (Apis mellifera L., PBV) collected using bee venom collector. Antigenic potential of PBV was examined by active systemic anaphylaxis (ASA) in guinea pigs. PBV was subcutaneously administered at 0.025 and 0.05 mg/kg and also as a suspension with adjuvant (Freund's complete adjuvant, FCA). Ovalbumin (OVA) as a suspension with adjuvant was used to introduce positive control response. In the weight measurement and clinical observation, experimental groups didn't show any significant changes compared with control group. In the autopsy of body, the abnormalities of lung were detected only in the positive control. In the ASA test, experimental groups didn't show any symptoms of anaphylaxis like piloerection, hyperpnea and staggering gait. These results suggested that PBV didn't have antigenic potential in guinea pig.
Keywords
Apis mellifera; Purified bee venom; Antigenicity; Active systemic anaphylaxis;
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