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Anti-diabetic Effects of Mixed Water Extract from Ginseng Radix Rubra, Acanthopanacis Cortex, and Cordyceps  

Ko, Sung-Kwon (Korea Ginseng Institute, Chung Ang University)
Kim, Jae-Soo (DOWZON pharm Co., LTD.)
Choi, Yong-Eui (Korea Ginseng Institute, Chung Ang University)
Lee, Seung-Jung (Korea Ginseng Institute, Chung Ang University)
Park, Kyeong-Soo (School of Pharmacy, Kyung Hee University)
Chung, Sung-Hyun (School of Pharmacy, Kyung Hee University)
Publication Information
Korean Journal of Pharmacognosy / v.33, no.4, 2002 , pp. 337-342 More about this Journal
Abstract
The effect of water extract composed of panax ginseng radix rubra, acanthopanacis cortex, and cordyceps (PAC) on diabetic animal models were investigated in two different diabetic animal models. FAC water extract significantly reduced the plasma glucose levels on day 30 as compared with the diabetic control group in $KKA^Y$ obese, hyperglycemic and hyperglycemic and hyperinsulinemic mice, and also reduced the plasma glucose levels as well as total cholesterol in multiple low dose (MLD) strep tozotocin-induced diabetic SD rats. PAC water extract also showed an inhibitory effect on reduction of body weight and on development of MLD STZ-induced diabetic state. Elevated kidney hypertrophy, which is a characteristic feature shown in early stage of diabetic nephropathy and calculated as the ratio of kidney mass (g) relative to the body weight (g), was also markedly improved in PAC water extract- treated group as compared to the diabetic control group. Taken together, these data suggest that PAC water extract may have a potential as a antidiabetic agent in type 2 diabetes mellitus.
Keywords
panax ginseng radix rubra; acanthopanacis cortex; cordyceps; $KKA^Y$ mice; multiple low dose (MLD) streptozotocin-induced diabetic SD rats; kidney hypertrophy;
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1 Sanata, S., Kondo, N., Shoji, J., Tanaka, O. and Shibata. S. (1974) Studies on the saponins of ginseng. I. Structure of ginseng-R_0, Rb_1, Rb_2, Rc and Rd. Chem. Pharm. Bull, 22(2) : 421   DOI
2 Ahn YJ., Park SJ., Lee SG., Shin SC. and Choi DH. (2000) Cordycepin: selective growth inhibitor derived from liquid culture of Cordyceps militaris against Clostridium spp. J Agric Food Chem, 48(7): 2744-2748   DOI   ScienceOn
3 Kimura, M., Waki L., Chujo, T., Kikuchi, T., Hiyama, C., Yamazaki, K. and Tanaka, O. (1981) Effects of hypoglycemic components in Ginseng radix on blood insulin level in alloxan diabetic mice and on insulin release from pefused rat pancreas. J. Pharm. Dyn., 4(6): 410-417   DOI
4 Shao, CJ., Kasai, R., Xu, JD. and Tanaka, O. (1989) Saponins from leaves of Acanthopanax senticosus Harms., Ciwujia : Structure of ciwujianoside C_1, C_2, C_3, C_4, D_1, D_2 and E. Chem. Pharm. Bull., 36: 601-608
5 Hacker B. and Medon PJ. (1984) Cytotoxic effects of Eleutherococcus senticosus aquous extracts in combination with N^6-$\bigtriangleup$^2-isopentenyl) adenosine and 1--$\beta$-D-arabinofuranosy1 cytosine against L 1210 leukemia cells. J. Pharm. Sci. 73: 270-272   DOI   PUBMED
6 Yokozawa, KobaYashi, T., Oura, H. and Kawashima, Y. (1985) Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb_2 in streptozotocin-diabetic rats. Chem. Pharm. Bull., 33: 869-872   DOI   ScienceOn
7 Zhao-Long W., Xiao-Xia W. and Wei-Ying C. (2000) Inhibitory effect of Cordyceps sinensis and Cordyceps mititaris on human glomerular mesangial cell proliferation induced by native LDL. Cell Biochem Funct, 18(2): 93-97   DOI   ScienceOn
8 Rakesh Kakkar., Subrahmanyam V. and Mantha. (1997) Andoxydant defense system diabetic kidney : A time course study. Life Sciences, 60: 667-679   DOI   ScienceOn
9 Bohn, B., Nebe, CT. and Birr, C. (1987) Durch fluzy tometrische Untersushungen auf Immunomodulatorische Wirkungen von Eleutherococcus senticosus extiact. Arzneim anticancer effect in leaves. Yakhak Hoeji, 37: 1193-1196
10 육창수(1972) 현대 본초학, 117: 고문사, 서울
11 Ikumoto T., Sasaki S., Namba H., Toyama R., Moiitoki H. and Mouri T. (1991) Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria. Yakugaku Zasshi, 111(9): 504-509
12 Medon, PJ., Ferguson, PW., and Watson, CF. (1984) Effects of Eleutherococcus senticosus extracts on hexobarbital metabolism in vivo in vitro. J. Ethnopharmacol. 10: 235-241   DOI   ScienceOn
13 Shao, CJ, Kasai, R., Xu, JD. and Tanaka, O. (1989) Saponins from leaves of Acanthopanax senticosus Harms., Ciwujia : Structure of ciwujianoside A_1, A_2, A_3, A_4 and D_3_. Chem. Pharm. Bull., 37: 42-45   DOI
14 Yang JC., Xu Hz. and Lin TS. (1984) Interferon induction by Acanthopanax senticosus polysaccharide and by sodium carboxymethyl starch in S 801 and S 7811 cell culture. Chin. J. Microbiol. Immunol., 4: 329-330
15 江蘇新醫學院(1982) 中約大辭典, 28: 成輔社, 상해
16 Xu, RS., Feng, SC., Fang, ZY., Ye, CCl., Zhai, SK. and Shen, ML. (1983) Polysaccharide components of the roots of Acanthopanax senticosus. Kexue Tongbao, 28: 185-187
17 Nishiyama, N. and Kamegaya, T. (1985) Effect of Eleutherococcus senticosus and its components on sex and learning-behaviors and tyrosine hydroxylase activities of adrenal gland and hypothalamic regions in chronic stressed mice. Shoyakugaku Zasshi, 39: 238-242
18 Kitagawa, I., Taniyama, T., Shibuya, H., Nota, T. and Yoshikawa, M. (1987) Chemical studies on crude drug processing. V. On the constituents of ginseng radix rubra (2): Comparison of the constituents of white ginseng and red ginseng prepared from the same Panax ginseng root. Yakugaku Zasshi. 107(7): 495-505   DOI
19 Takasugi, N., Moriguchi, T., and Fuwa, TS. (1985) Effects of Eleutherococcus senticosus and its components on rectal temparature, body and grip tones, motor coordination and exploratory and spotaneous movements in acute stressed mice. Shoyakugaku Zasshi, 39: 232-237
20 Hikino, H., Takahashi, M., Otake, K. and Konno, C. (1986) Isolation and hypoglycemic activity of eleuthrans A, B, C, D, E, F and G, glycans of Acanthopanax senticosus roots. J. Nat Prod, 49: 193-297   DOI
21 Barenboim GM., Sterline AG., Bebyakova NV, Ribokas AA. and Fuks BB. (1986) Investigation of the pharmacokinetics and mechanism of action of Eleutherococcus glycosides. VIII. Investigation of natural killer activation by the Eleutherococcus extract. Khim. Farm. Zh., 20: 914-917
22 Fang JN., Proksch A. and Wagner H. (1985) Immunologically active polysaccharides of Acanthopanax senticosus. Phytochemistry, 24: 2619-2622   DOI   ScienceOn
23 Toshinan Takamura., Hitoshi Ando. and Yukihiro Nagai. (1999) Pioglitazone prevents mice from multiple low-dose streptozotocin-induced insulitis and diabetes. Diabetes Res. Clin. Pract, 99: 107-114
24 김춘미, 한규선(1985) 인삼 단백질의 방사선 방어작용. 약학회지, 29(5): c
25 Xu, RS., Feng, SC., Fan, ZY. and Zhai, SK. (1980) Immunopotentiating polysaccharides of Acanthopanax senticosus, Chem. Prod. Proc. Sino-Am., Symp., 271-274
26 육창수(1981) 한국약품식물자된도감, 276: 진명출판사, 서울