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http://dx.doi.org/10.14406/acu.2013.039

Anti-Inflammatory Effect of Bower Actinidia in LPS-Stimulated RAW264.7 Cells  

Kim, Young-Jun (Department of Meridian & Acupoint, College of Oriental Medicine, Dong-Eui University)
Song, Choon-Ho (Department of Meridian & Acupoint, College of Oriental Medicine, Dong-Eui University)
Publication Information
Korean Journal of Acupuncture / v.30, no.4, 2013 , pp. 243-251 More about this Journal
Abstract
Objectives : Bower Actinidia has been widely used for treatment of inflammatory diseases, such as jaundice, cystolithiasis. However, the mechanism of its anti-inflammatory activity has not been clarified. In this study, we investigated the inhibitory effect of Bower Actinidia pharmacopuncture extract(BA) on LPS-induced inflammation. Methods : The effect of BA was analyzed by ELISA, RT-PCR and Western blotting in LPS-stimulated RAW264.7 cells. Results : We found that BA suppressed not only the mRNA expression of pre-inflammatory cytokines, cyclooxygenase-2(COX-2) and inducible nitric oxide synthase(iNOS), but also the phosphorylation of ERK, JNK and p38. Conclusions : These results suggest that BA exerts an anti-inflammatory effect through the regulation of the mitogen-activated protein kinase(MAPK) pathway, thereby decreasing production of pre-inflammatory cytokines.
Keywords
Bower Actinidia; pharmacopuncture; inflammation; MAPK; RAW264.7 cells;
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Times Cited By KSCI : 7  (Citation Analysis)
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