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http://dx.doi.org/10.18325/jkmr.2021.31.4.117

Effects of Unripe Rubus Coreanus Extract on Upper Body Obesity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial  

Ha, Ki Chan (Healthcare Claims & Management Inc.)
Kim, Hye Mi (Healthcare Claims & Management Inc.)
Baek, Hyang Im (Healthcare Claims & Management Inc.)
Jeong, Da Young (Healthcare Claims & Management Inc.)
Kim, Eun (Central R&D Center, B&Tech Co., Ltd.)
Lee, Ki Hoon (Central R&D Center, B&Tech Co., Ltd.)
Kim, Ha Rim (Department of Korean Medicinal Physiology, College of Korean Medicine, Wonkwang University)
Kwon, Kang Beom (Department of Korean Medicinal Physiology, College of Korean Medicine, Wonkwang University)
Kim, Sunoh (Central R&D Center, B&Tech Co., Ltd.)
Lee, Jung Han (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Wonkwang University)
Publication Information
Journal of Korean Medicine Rehabilitation / v.31, no.4, 2021 , pp. 117-127 More about this Journal
Abstract
Objectives Previously, we demonstrated that a 5% ethanol extract of unripe Rubus coreanus (5-uRCK) and ellagic acid has hypocholesterolemic and antiobesity activity in high-fat diet-fed animals. Therefore, we conducted a clinical study on the anti-obesity effect of 5-uRCK in 140 Korean adults (aged 19-70 years, body mass index (BMI) ≥25 kg/m2). Methods The participants were randomly assigned to two groups and were administered the placebo (n=70) or 5-uRCK extract (800 mg, n=70) daily for 12 weeks. The subjects were instructed to maintain their usual dietary intake and normal physical activity. Anthropometrics, body composition (dual-energy X-ray absorptiometry), and blood parameters were compared between the two groups. Results Average body weight and BMI did not show any significant changes; however, changes in upper body fat mass between the two groups was significantly different, as determined using analysis of covariance adjusted for baseline of percent body fat and drinking units. Moreover, Although not significant, the trunk fat mass and percent trunk fat tended to decrease after 5-uRCK supplementation. There was no significant difference in other laboratory biomarkers between the two groups. All safety parameters were within normal ranges in the both group. Conclusions In the present study, 5-uRCK significantly reduced upper body fat in obese subjects after 12 weeks, which indicates that it may help improve android-type obesity. Furthermore, the supplement is safe and well tolerated.
Keywords
Unripe Rubus coreanus (5-uRCK); Obesity; Body mass index; Upper body fat; Percent trunk fat;
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