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http://dx.doi.org/10.9713/kcer.2021.59.3.379

Development of An Improved Acetone-Water Fractional Precipitation Process for Purification of Paclitaxel from Taxus chinensis and Its Kinetic and Thermodynamic Analysis  

Kang, Hoe-Jong (Department of Chemical Engineering, Kongju National University)
Kim, Jin-Hyun (Department of Chemical Engineering, Kongju National University)
Publication Information
Korean Chemical Engineering Research / v.59, no.3, 2021 , pp. 379-392 More about this Journal
Abstract
In this study, an improved acetone-water fractional precipitation process for paclitaxel using ultrasonic cavitation bubbles and gas bubbles was developed. Compared to the conventional method, the time required for precipitation has been reduced by 20~25 times. In addition, the particle size of paclitaxel decreased by 3.5~5.5 times and the diffusion coefficient of paclitaxel increased by 3.5~6.7 times. In the case of precipitation using ultrasonic cavitation bubbles, as the ultrasonic power increased and the temperature decreased, the precipitation rate constant increased. In the case of precipitation using gas bubbles, as the gas flow rate increased and the temperature decreased, the precipitation rate constant increased. Thermodynamic parameters revealed the exothermic, irreversible, and nonspontaneous nature of the improved fractional precipitation.
Keywords
Paclitaxel; Fractional precipitation; Ultrasound; Cavitation bubbles; Gas bubbles;
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Times Cited By KSCI : 1  (Citation Analysis)
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