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Experimental Analysis on Regularities of Synergistic Interaction of Temperature with Physico-Chemical Environmental Factors  

김진규 (한국원자력연구소)
신해식 (한국원자력연구소)
블라디슬라프페틴 (러시아의료방사선연구센터)
이영엽 (전주대학교 자연과학부)
Publication Information
Korean Journal of Environmental Biology / v.20, no.2, 2002 , pp. 165-172 More about this Journal
Abstract
The combined action of two factors on organisms can be either antagonistic, non-effective, additive or synergistic. Although synergism is of biological importance, the common features of synergistic interaction between harmful environmental factors are largely unknown. The purpose of this study is to establish general rules describing the response of various organisms to the combined action of heat with another inactivating agent. Synergistic interaction due to the simultaneous treatment of hyperthermia with ionizing or non-ionizing radiation has been analyzed using the experimental data mainly obtained with yeast cells. In addition, the results reported by others for viruses, bacterial spores, cultured mammalian cells, plants and animals were also analyzed to check the regularities revealed. The common rules of the synergistic interaction obtained in this study can be summarized as follows. For any constant rate of exposure, the synergy can be observed only within a certain temperature range. An increase in exposure rate resulted in an increase of this specific temperature and vice versa. For a constant temperature at which the irradiation occurs, synergy can be observed within a certain dose rate range. As the exposure temperature is reduced, the optimal intensity decreases and vice versa. A new conception taken into consideration those regularities can make a clue for environmental disaster preventive analysis of the synergy of radiation with the other factor.
Keywords
synergism; radiation; hyperthermia; environmental factor; disaster;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 /
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