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http://dx.doi.org/10.3347/kjp.2021.59.3.297

Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo  

Zhang, Run-Hui (Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University)
Jin, Runhao (School of nursing Yanbian University)
Deng, Hao (Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University)
Shen, Qing-Kun (Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University)
Quan, Zhe-Shan (Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University)
Jin, Chun-Mei (Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University)
Publication Information
Parasites, Hosts and Diseases / v.59, no.3, 2021 , pp. 297-301 More about this Journal
Abstract
Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low cytotoxicity. For this reason, HE was selected for in vivo experiments. HE showed 64.8%±13.1% inhibition for peritoneal tachyzoites in mice, higher than spiramycin 56.8%±6.0%. Biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, glutathione, and malondialdehyde, illustrated that HE was a good inhibitor of T. gondii in vivo. This compound was also effective in relieving T. gondii-induced liver damage. Collectively, it was demonstrated that HE had potential as an anti-T. gondii agent.
Keywords
Toxoplasma gondii; hederagenin; inhibition; in vitro; in vivo;
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