Browse > Article
http://dx.doi.org/10.3347/kjp.2011.49.1.73

A Paragonimiasis Patient with Allergic Reaction to Praziquantel and Resistance to Triclabendazole: Successful Treatment after Desensitization to Praziquantel  

Kyung, Sun-Young (Department of Medicine, Gachon University Gil Medical Center)
Cho, Yong-Kyun (Department of Medicine, Gachon University Gil Medical Center)
Kim, Yu-Jin (Department of Medicine, Gachon University Gil Medical Center)
Park, Jeong-Woong (Department of Medicine, Gachon University Gil Medical Center)
Jeong, Sung-Hwan (Department of Medicine, Gachon University Gil Medical Center)
Lee, Jae-Ik (Department of Thoracic Surgery, Gachon University Gil Medical Center)
Sung, Yon-Mi (Department of Radiology, Gachon University Gil Medical Center)
Lee, Sang-Pyo (Department of Medicine, Gachon University Gil Medical Center)
Publication Information
Parasites, Hosts and Diseases / v.49, no.1, 2011 , pp. 73-77 More about this Journal
Abstract
Paragonimiasis is an infectious disease caused by trematodes of the genus Paragonimus. This trematode can be treated successfully with praziquantel in more than 90% of the cases. Although praziquantel is generally well tolerated, anaphylactic reactions to this drug have been reported in a few cases. We report here a 46-year-old Korean female with paragonimiasis, presumed to be due to Paragonimus westermani, who displayed an allergic reaction to praziquantel and resistance to triclabendazole treatment. The patient was successfully treated with praziquantel following a rapid desensitization procedure. Desensitization to praziquantel could be considered when no alternative drugs are available.
Keywords
Paragonimus; paragonimiasis; praziquantel; triclabendazole; drug allergy; desensitization;
Citations & Related Records

Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
연도 인용수 순위
1 Singh TS, Mutum SS, Razaque MA. Pulmonary paragonimiasis: clinical features, diagnosis and treatment of 39 cases in Manipur. Trans R Soc Trop Med Hyg 1986; 80: 967-971.   DOI
2 Mukae O, Taniguchi H, Ashitani J, Matsukura S, Uchiyama F, Nawa Y. Case report: paragonimiasis westermani with seroconversion from immunoglobulin IgM to IgG antibody with the clinical course. Am J Trop Med Hyg 2001; 65: 837-839.   DOI
3 Jeon K, Koh WJ, Kim H, Kwon OJ, Kim TS, Lee KS, Han J. Clinical features of recently diagnosed pulmonary paragonimiasis in Korea. Chest 2005; 128: 1423-1430.   DOI   ScienceOn
4 Shorter D, Makone I, Elliott EJ. Fever and urticaria in an African refugee. J Paediatr Child Health 2006; 42: 731-733.   DOI   ScienceOn
5 Brindley PJ, Sher A. Immunologic involvement in the efficacy of praziquantel. Exp Parasitol 1990; 71: 245-248.   DOI   ScienceOn
6 Matsumoto J. Adverse effects of praziquantel treatment of Schistosoma japonicum infection: involvement of host anaphylactic reactions induced by parasite antigen release. Int J Parasitol 2002; 32: 461-471.   DOI   ScienceOn
7 Castells M. Desensitization for drug allergy. Curr Opin Allergy Clin Immunol 2006; 6: 476-481.   DOI
8 Liu T. Allergic manifestation after pyquiton treatment of schistosomiasis. Chinese J Parasitol Parasit Dis 1984; 2: 192-203 (in Chinese).
9 Huang SW. A clinical approach to a patient with praziquantel hypersensitivity. J Allergy Clin Immunol 1992; 90: 867.   DOI
10 Cho SY, Hong ST, Rho YH, Choi SY, Han YC. Application of micro-ELISA in serodiagnosis of Human paragonimiasis. Korean J Parasitol 1981; 19: 151-156.   DOI
11 Calvopina M, Guderian RH, Paredes W, Chico M, Cooper PJ. Treatment of human pulmonary paragonimiasis with triclabendazole: clinical tolerance and drug efficacy. Trans R Soc Trop Med Hyg 1998; 92: 566-569.   DOI
12 Talaie H, Emami H, Yadegarinia D, Nava-Ocampo AA, Massoud J, Azmoudeh M, Mas-Coma S. Randomized trial of a single, double and triple dose of 10 mg/kg of a human formulation of triclabendazole in patients with fascioliasis. Clin Exp Pharmacol Physiol 2004; 31: 777-782.   DOI   ScienceOn
13 White AA, Stevenson DD, Simon RA. The blocking effect of essential controller medications during aspirin challenges in patients with aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol 2005; 95: 330-335.   DOI   ScienceOn
14 DeFrain M, Hooker R. North American paragonimiasis: case report of a severe clinical infection. Chest 2002; 121: 1368-1372.   DOI   ScienceOn
15 Roque FT, Ludwick RW, Bell JC. Pulmonary paragonimiasis; a review with case reports from Korea and the Philippines. Ann Intern Med 1953; 38: 1206-1221.   DOI   ScienceOn
16 Yokogawa M. Paragonimus and paragonimiasis. Adv Parasitol 1965; 3: 99-158.
17 Im JG, Whang HY, Kim WS, Han MC, Shim YS, Cho SY. Pleuropulmonary paragonimiasis: radiologic findings in 71 patients. Am J Roentgenol 1992; 159: 39-43.   DOI   ScienceOn
18 Sadun EH, Buck AA. Paragonimiasis in South Korea-immunodiagnostic, epidemiologic, clinical, roentgenologic and therapeutic studies. Am J Trop Med Hyg 1960; 9: 562-599.   DOI
19 Kim TS, Han J, Shim SS, Jeon K, Koh WJ, Lee I, Lee KS, Kwon OJ. Pleuropulmonary paragonimiasis: CT findings in 31 patients. Am J Roentgenol 2005; 185: 616-621.   DOI   ScienceOn
20 Shen C, Choi MH, Bae YM, Yu G, Wang S, Hong ST. A case of anaphylactic reaction to praziquantel treatment. Am J Trop Med Hyg 2007; 76: 603-605.