Browse > Article
http://dx.doi.org/10.3347/kjp.2010.48.3.225

Haplorchis taichui as a Possible Etiologic Agent of Irritable Bowel Syndrome-Like Symptoms  

Watthanakulpanich, Dorn (Department of Helminthology, Faculty of Tropical Medicine, Mahidol University)
Waikagul, Jitra (Department of Helminthology, Faculty of Tropical Medicine, Mahidol University)
Maipanich, Wanna (Department of Helminthology, Faculty of Tropical Medicine, Mahidol University)
Nuamtanong, Supaporn (Department of Helminthology, Faculty of Tropical Medicine, Mahidol University)
Sanguankiat, Surapol (Department of Helminthology, Faculty of Tropical Medicine, Mahidol University)
Pubampen, Somchit (Department of Helminthology, Faculty of Tropical Medicine, Mahidol University)
Praevanit, Rangson (Bangkok School of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University)
Mongkhonmu, Srisuchat (Bangkok School of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University)
Nawa, Yukifumi (Department of Helminthology, Faculty of Tropical Medicine, Mahidol University)
Publication Information
Parasites, Hosts and Diseases / v.48, no.3, 2010 , pp. 225-229 More about this Journal
Abstract
The aim of this study is to clarify the clinical features of Hap/orchis taichui infection in humans in Nan Province, Thailand, and to correlate the clinical features with irritable bowel syndrome (IBS)-like symptoms. In this study area, only H. taichui, but neither other minute intestinal flukes nor small liver flukes were endemic. The degree of infection was determined by fecal egg counts and also by collecting adult worms after deworming. The signs and symptoms of individual patients together with their hematological and biochemical laboratory data were gathered to evaluate the relationship between the clinical features and the severity of infection. Special emphasis was made to elucidate the possible similarities of the clinical features of H. taichui infection and IBS-like symptoms. The results showed useful clinical information and the significant (> 50%) proportion of haplorchiasis patients complained of abdominal pain, lassitude, and flatulence, which were the important diagnostic symptoms of IBS. This study has reported a possible link between H. taichui and IBS, and H. taichui might probably play a role in the etiology of these IBS-like symptoms.
Keywords
Haplorchis taichui; clinical feature; irritable bowel syndrome-like symptom;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By Web Of Science : 2  (Related Records In Web of Science)
Times Cited By SCOPUS : 4
연도 인용수 순위
1 Thu ND, Dalsgaard A, Loan LT, Murrell KD. Survey for zoonotic liver and intestinal trematode metacercariae in cultured and wild fish in An Giang Province, Vietnam. Korean J Parasitol 2007; 45: 45-54.   과학기술학회마을   DOI   ScienceOn
2 Rim HJ, Sohn WM, Yong TS, Eom KS. Chai JY, Min DY, Lee SH, Hoang EH, Phommasack B, Insisengmay S. Fishborne trematode metacercariae detected in freshwater fish from Vientiane Municipality and Savannakhet Province, Lao PDR. Korean J Parasitol 2008; 46: 253-260.   과학기술학회마을   DOI   ScienceOn
3 Keiser J, Utzinger J. Food-borne trematodiases. Clin Microbiol Rev 2009; 22: 466-483.   DOI   ScienceOn
4 Maipanich W, Waikagul J, Watthanakulpanich D, Muennoo C, Sanguankiat S, Pubampen S, Anantaphruti MT, Nuamtanong S, Yoonuan T, Visetsuk K. Intestinal parasitic infections among inhabitants of the North, West-central and Eastern border areas of Thailand. J Trop Med Parasitol 2004; 27: 51-58.
5 Grundmann O, Yoon SL. Irritable bowel syndrome: epidemiology, diagnosis and treatment: an update for health-care practitioners. J Gastroenterol Hepatol 2010; 25: 691-699.   DOI   ScienceOn
6 Stark D, van Hal S, Marriott D, Ellis J, Harkness J. Irritable bowel syndrome: a review on the role of intestinal protozoa and the importance of their detection and diagnosis. Int J Parasitol 2007; 37: 11-20.   DOI   ScienceOn
7 Katz N, Chaves A, Pellegrino J. A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Rev Inst Med Trop Sao Paulo 1972; 14: 397-400.
8 Chuboon S, Wongsawad C, Ruamsuk A, Nithikathkul C. Survival of Haplorchis taichui metacercariae in Lab-Pla, Thai traditional food preparation. Southeast Asian J Trop Med Public Health 2005; 36 (suppl 4): 110-111.
9 Whitehead WE, Drossman DA. Validation of symptom-based diagnostic criteria for irritable bowel syndrome: a critical review. Am J Gastroenterol 2010; 105: 814-820.   DOI   ScienceOn
10 Ryang YS, Lee CY, Lee KJ, Lee SH, Chai JY. An incidental case of human Heterophyes nocens infection diagnosed by sectional morphology in a biopsy specimen of the small intestine. Korean J Parasitol 1999; 37: 189-194.   DOI   ScienceOn
11 Waikagul J. Intestinal fluke infections in Southeast Asia. Southeast Asian J Trop Med Public Health 1991; 22: 158-162.
12 Chai JY, Park JH, Han ET, Guk SM, Shin EH, Lin A, Kim JL, Sohn WM, Young TS, Eom KS, Min DY, Hwang EH, Phommasack B, Insisiengmay B, Rim JH. Mixed infections with Opisthorchis viverrini and intestinal flukes in residents of Vientiane Municipality and Saravane Province in Laos. J Helminthol 2005; 79: 283-289.   DOI   ScienceOn
13 Chai JY, Han ET, Shin EH, Sohn WM, Yong TS, Eom KS, Min DY, Um JY, Park MS, Hoang EH, Phommasack B, Insisiengmay B, Lee SH, Rim HJ. High prevalence of Haplorchis taichui, Prosthodendrium molenkampi and other helminth infections among people in Khammouane province, Lao PDR. Korean J Parasitol 2009; 47: 243- 247.   과학기술학회마을   DOI   ScienceOn
14 Lovis L, Mak TK, Phongluxa K, Soukhathammavong P, Sayasone S, Akkhavong K, Odermatt P, Keiser J, Felger I. PCR diagnosis of Opisthorchis viverrini and Haplorchis taichui infections in a Lao community in an area of endemicity and comparison of diagnostic methods for parasitological field surveys. J Clin Microbiol 2009; 47: 1517-1523.   DOI   ScienceOn
15 Sayasone S, Vonghajack Y, Vanmany M, Rasphone O, Tesana S, Utzinger J, Akkhavong K, Odermatt P. Diversity of human intestinal helminthiasis in Lao PDR. Trans R Soc Trop Med Hyg 2009; 103: 247-254.   DOI   ScienceOn
16 Kumchoo K, Wongsawad C, Chai JY, Vanittanakorn P, Rojanapaibul A. High prevalence of Haplorchis taichui metacercariae in cyprinoid fish from Chiang Mai Province, Thailand. Southeast Asian J Trop Med Public Health 2005; 36: 451-455.
17 Thien PC, Dalsgaard A, Thanh BN, Olsen A, Murrell KD. Prevalence of fishborne zoonotic parasites in important cultured fish species in the Mekong Delta, Vietnam. Parasitol Res 2007; 101: 1277-1284.   DOI   ScienceOn
18 Chai JY, Lee SH. Intestinal trematodes of humans in Korea: Metagonimus, heterophyids and echinostomes. Korean J Parasitol 1990; 28 (suppl): 103-122.   DOI
19 Sukontason K, Unpunyo P, Sukontason KL, Piangjai S. Evidence of Haplorchis taichui infection as pathogenic parasite: three case reports. Scand J Infect Dis 2005; 37: 388-390.   DOI   ScienceOn
20 Tornblom H, Lindberg G, Nyberg B, Veress B. Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology 2002; 123: 1972- 1979.   DOI   ScienceOn
21 Kaewkes S, Elkins DB, Sithithaworn P, Haswell-Elkins MR. Comparative studies on the morphology of the eggs of Opisthorchis viverrini and lecithodendriid trematodes. Southeast Asian J Trop Med Public Health 1991; 22: 623-630.
22 Kaewpitoon N, Kaewpitoon SJ, Pengsaa P. Opisthorchiasis in Thailand: review and current status. World J Gastroenterol 2008; 14: 2297-2302.   DOI   ScienceOn