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A Study on the Factors Affecting Entrapment Efficiency and Particle Size of Ethosomes  

Jin, Byung Suk (Department of Applied Chemistry, Dongduk Women's University)
Lee, Sang Mook (Department of Applied Chemistry, Dongduk Women's University)
Lee, Kwang Hee (Nano System Engineering, Inha University)
Publication Information
Applied Chemistry for Engineering / v.17, no.2, 2006 , pp. 138-143 More about this Journal
Abstract
Ethosome is a liquid crystalline vesicle prepared by hydration of ethanol-dissolved lecithin with a solution containing hydrophilic components. Investigation of factors affecting the entrapment efficiency and particle size of ethosomes was carried out, because the high entrapment efficiency and small particle size are prerequisite in developing ethosomes as a drug delivery system. The variations of properties of ethosomes with constituent composition and preparation method were examined using a calcein as a hydrophilic marker. It was observed that the amount of ethanol and calcein solution, phosphatidyl choline content in lecithin, preparation temperature, stirring rate, and PBS addition method had a considerable effect on the properties of ethosome. Sonication treatment resulted in the reduction of entrapment efficiency of ethosome, which was due to the release of entrapped components in the vesicles by strong sonication vibration.
Keywords
ethosome; hydrated liquid crystalline vesicle; entrapment efficiency; particle size; lecithin;
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