Browse > Article
http://dx.doi.org/10.6111/JKCGCT.2012.22.2.099

Bioactivity behavior of biphasic calcium phosphate powders prepared by co-precipitation method  

Kim, Tae-Wan (School of Materials Science Engineering, Pusan National University)
Kim, Dong-Hyun (School of Materials Science Engineering, Pusan National University)
Jin, Hyeong-Ho (School of Materials Science Engineering, Pusan National University)
Lee, Heon-Soo (Division of Electrical and Electronic Engineering, Daegu Technical University)
Park, Hong-Chae (School of Materials Science Engineering, Pusan National University)
Yoon, Seog-Young (School of Materials Science Engineering, Pusan National University)
Abstract
The co-precipitation technique has been applied to synthesize biphasic calcium phosphate (BCP). $Ca(NO_3)_2{\cdot}4H_2O$ and $(NH_4)_2HPO_4$ as the starting materials was used. X-ray diffraction (XRD) and Fourier transformed infrared (FT-IR) spectroscopy were used to characterize the structure of as-synthesized and calcined BCP powders. After immersion in Hanks' Balanced Salt Solution (HBSS), for 1 week a precipitation started to be formed with individual small granules on the specimen surface. An MTT assay indicated that BCP powders have no cytotoxic effects on MG-63 cells, and that they have good biocompatibility.
Keywords
Biphasic calcium phosphate; Bioactivity; Co-precipitation; Hanks' balanced salt solution;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 H.S. Lee, T.W. Kim, D.H. Kim, H.C. Park and S.Y. Yoon, "Suitability evaluation of magnesium substituted biphasic calcium phosphates prepared by coprecipitation method", J. Kor. Cry. Grow. Cry. Tech. 20 (2010) 237.   과학기술학회마을   DOI   ScienceOn
2 C.W. Song, T.W. Kim, D.H. Kim, H.C. Park and S.Y. Yoon, "Synthesis and characterization of silicon ion substituted biphasic calcium phosphate", J. Kor. Cry. Grow. Cry. Tech. 20 (2010) 243.   과학기술학회마을   DOI   ScienceOn
3 N. Kivrak and A.C. Tas, "Synthesis of calcium hydroxyapatite-tri calcium phosphate (HA-TCP) composite bioceramic powders and their sintering behavior", J. Am. Ceram. Soc. 81 (1998) 2245.
4 S.V. Dorozhkin and M. Epple, "Biological and medical significance of calcium phosphates", Angew. Chem. Int. Ed. 41 (2002) 3130.   DOI   ScienceOn
5 J. Pena and M. Vallet-Regi, "Hydroxyapatite, tricalcium phosphate and biphasic materials prepared by a liquid mix technique", J. Euro. Ceram. Soc. 23 (2003) 1687.   DOI   ScienceOn
6 M. Vallet-Regi, "Ceramics for medical applications", J. Chem. Soc. Dalton. Trans. (2001) 97.
7 S.R. Kim, J.H. Lee, Y.T. Kim, D.H. Riu, S.J. Jung, Y.J. Lee, S.C. Chung and Y.H. Kim, "Synthesis of Si, Mg substituted hydroxyapatites and their sintering behaviors", Biomaterials 24 (2003) 1389.   DOI   ScienceOn
8 S. Kannan, I.A.F. Lemos, J.H.G. Rocha and J.M.F. Ferreira, "Synthesis and characterization of magnesium substituted biphasic mixtures of controlled hydroxyapatite/ $\beta$-tricalcium phosphate ratios", J. Solid. State. Chem. 178 (2005) 3190.   DOI   ScienceOn
9 R.W. Bucholz, A. Carlton and R.E. Holmes, "Hydroxyapatite and tricalcium phosphate bone graft substitutes", Orthop. Clin. North. Am. 18 (1987) 323.
10 M. Jarcho, "Biological aspects of calcium phosphates: Properties and applications", Dent. Clin. North. Am. 30 (1986) 25.
11 L.L. Hench, "Bioceramics", J. Am. Ceram. Soc. 81 (1998) 1705.
12 C.P.A.T. Klein, A.A. Driessen, K. de Groot and A. van den Hooff, "Biodegradation behavior of various calcium phosphate materials in bone tissue", J. Biomed. Mater. Res. A 17 (1983) 769.   DOI   ScienceOn
13 D. Buser, B. Hoffmann, J.P. Bernard, et al., "Evaluation of filling materials in membrane-protected bone defects. A comparative histomorphometrib study in the mandible of miniature pigs", Clin. Oral. Implants. Res. 9 (1998) 137.   DOI   ScienceOn
14 J.M. Bouler, R.Z. LeGeros and G. Daculsi, "Biphasic calcium phosphates: Influence of three synthesis parameters on the HA/$\beta$-TCP ratio", J. Biomed. MaterRes. A 51 (2000) 680.   DOI   ScienceOn
15 M. Jarcho, "Calcium phosphate ceramics as hard tissue prosthetic", Clin. Orthop. Relat. Res. 157 (1981) 259.
16 R.Z. LeGeros, S. Lin, R. Rohanizadeh, D. Mijares and J.P. LeGeros, "Biphasic ca1cium phosphate bioceramics: preparation, properties and applications", J. Mater. Sci. Mater. Med. 14 (2003) 201.   DOI   ScienceOn