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http://dx.doi.org/10.11620/IJOB.2019.44.3.101

Antimicrobial activity of Garcinia mangostana L. ethanol extract against Cutibacterium acnes and Staphylococcus aureus  

Lim, Yun Kyong (Korean Collection for Oral Microbiology, College of Dentistry, Chosun University)
Yoo, So Young (Medi Bio Lab Co., Ltd.)
Park, Soon-Nang (Korean Collection for Oral Microbiology, College of Dentistry, Chosun University)
Lee, Dae Sung (Medi Bio Lab Co., Ltd.)
Kook, Joong-Ki (Korean Collection for Oral Microbiology, College of Dentistry, Chosun University)
Publication Information
International Journal of Oral Biology / v.44, no.3, 2019 , pp. 101-107 More about this Journal
Abstract
The purpose of this study was to investigate the antimicrobial activity of the ethanol extract of Garcinia mangostana L. (mangosteen) against Cutibacterium acnes (6 strains) and Staphylococcus aureus (6 strains). The antimicrobial activity of the mangosteen extract was evaluated based on its minimal bactericidal concentration. Cytotoxicity of the mangosteen extract against human embryonic kidney 293 (HEK 293) cells was determined using the cell counting method. The data showed that the mangosteen extract was not toxic to HEK 293 cells at a concentration of up to $16{\mu}g/mL$ and killed 87.0% and 99.9% of C. acnes and S. aureus after 10 minutes and 1 hour of treatment, respectively. These results suggest that ethanol extract of mangosteen can be used as an anti-acne agent.
Keywords
Garcinia mangostana; Antimicrobial effect; Cutibacterium acnes; Staphylococcus aureus;
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1 Xu N, Deng W, He G, Gan X, Gao S, Chen Y, Gao Y, Xu K, Qi J, Lin H, Shen L, Li X, Hu Z. Alpha- and gamma-mangostins exhibit anti-acne activities via multiple mechanisms. Immunopharmacol Immunotoxicol 2018;40:415-22. doi: 10.1080/08923973.2018.1519831.   DOI
2 Humphrey S. Antibiotic resistance in acne treatment. Skin Therapy Lett 2010;17:1-3.
3 Platsidaki E, Dessinioti C. Recent advances in understanding Propionibacterium acnes (Cutibacterium acnes) in acne. F1000Res 2018;7:2-12. doi: 10.12688/f1000research.15659.1.
4 Tsai TH, Tsai TH, Wu WH, Tseng JTP, Tsai PJ. In vitro antimicrobial and anti-inflammatory effects of herbs against Propionibacterium acnes. Food Chem 2010;119:964-8. doi: 10.1016/j.foodchem.2009.07.062.   DOI
5 Choi MH, Ryu EM, Oh DS, Shin HJ. Improvement of acne condition in skin care using camellia japonica L. extracts. Korean J Aesthet Cosmet Soc 2012;10:661-72.
6 Pothitirat W, Chomnawang MT, Gritsanapan W. Anti-acne inducing bacteria activity and $\alpha$-mangostin content of Garcinia mangostana fruit rind extracts from different provenience. Songklanakarin J Sci Technol 2009;31:41-7.
7 Gutierrez-Orozco F, Chitchumroonchokchai C, Lesinski GB, Suksamrarn S, Failla ML. $\alpha$-Mangostin: anti-inflammatory activity and metabolism by human cells. J Agric Food Chem 2013;61:3891-900. doi: 10.1021/jf4004434.   DOI
8 Lwin SM, Kimber I, McFadden JP. Acne, quorum sensing and danger. Clin Exp Dermatol 2014;39:162-7. doi: 10.1111/ced.12252.   DOI
9 Park TY, Lim YK, Lee DS, Kook JK. Antimicrobial effect of ethanol extract of Garcinia mangostana L. against Enterococcus faecalis isolated from human oral cavity. Int J Oral Biol 2018;43:129-32. doi: 10.11620/IJOB.2018.43.3.129.   DOI
10 Al-Massarani SM, El Gamal AA, Al-Musayeib NM, Mothana RA, Basudan OA, Al-Rehaily AJ, Farag M, Assaf MH, El Tahir KH, Maes L. Phytochemical, antimicrobial and antiprotozoal evaluation of Garcinia mangostana pericarp and $\alpha$-mangostin, its major xanthone derivative. Molecules 2013;18:10599-608. doi: 10.3390/molecules180910599.   DOI
11 Chomnawang MT, Surassmo S, Nukoolkarn VS, Gritsanapan W. Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria. J Ethnopharmacol 2005;101:330-3. doi: 10.1016/j.jep.2005.04.038.   DOI
12 Chomnawang MT, Surassmo S, Wongsariya K, Bunyapraphatsara N. Antibacterial activity of Thai medicinal plants against methicillin-resistant Staphylococcus aureus. Fitoterapia 2009;80:102-4. doi: 10.1016/j.fitote.2008.10.007.   DOI
13 Kim MJ, Kim CS, Park JY, Park SN, Yoo SY, Lee SY, Kook JK. Bacterial model system for screening and determining optimal concentration of anti-caries natural extracts. J Microbiol 2011;49:165-8. doi: 10.1007/s12275-011-1018-0.   DOI
14 Jo E, Choi MH, Kim HS, Park SN, Lim YK, Kang CK, Kook JK. Antimicrobial effects of oleanolic acid, ursolic acid, and sophoraflavanone G against Enterococcus faecalis and Propionibacterium acnes. Int J Oral Biol 2014;39:75-9.   DOI
15 Clinical and Laboratory Standards Institute. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: approved standard. CLSI document M7-A6. 6th ed. USA: Wayne Pennsylvania; 2005.
16 Skrabalak DS, Babish JG. Safety standards for occupational exposure to dichloromethane. Regul Toxicol Pharmacol 1983;3:139-43. doi: 10.1016/0273-2300(83)90038-7.   DOI
17 Perry AL, Lambert PA. Propionibacterium acnes. Lett Appl Microbiol 2006;42:185-8. doi: 10.1111/j.1472-765X.2006.01866.x.   DOI
18 Ritvo E, Del Rosso JQ, Stillman MA, La Riche C. Psychosocial judgements and perceptions of adolescents with acne vulgaris: a blinded, controlled comparison of adult and peer evaluations. Biopsychosoc Med 2011;5:11. doi: 10.1186/1751-0759-5-11.   DOI
19 Leyden JJ. A review of the use of combination therapies for the treatment of acne vulgaris. J Am Acad Dermatol 2003;49(3 Suppl):S200-10. doi: 10.1067/s0190-9622(03)01154-x.   DOI
20 Kumar B, Pathak R, Mary PB, Jha D, Sardana K, Gautam HK. New insights into acne pathogenesis: exploring the role of acne-associated microbial populations. Dermatol Sin 2016;34:67-73. doi: 10.1016/j.dsi.2015.12.004.   DOI
21 Weber N, Biehler K, Schwabe K, Haarhaus B, Quirin KW, Frank U, Schempp CM, Wolfle U. Hop extract acts as an antioxidant with antimicrobial effects against Propionibacterium acnes and Staphylococcus aureus. Molecules 2019;24:E223. doi: 10.3390/molecules24020223.   DOI
22 Tewtrakul S, Wattanapiromsakul C, Mahabusarakam W. Effects of compounds from Garcinia mangostana on inflammatory mediators in RAW264.7 macrophage cells. J Ethnopharmacol 2009;121:379-82. doi: 10.1016/j.jep.2008.11.007.   DOI
23 Fanelli M, Kupperman E, Lautenbach E, Edelstein PH, Margolis DJ. Antibiotics, acne, and Staphylococcus aureus colonization. Arch Dermatol 2011;147:917-21. doi: 10.1001/archdermatol.2011.67.   DOI