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http://dx.doi.org/10.14476/jomp.2012.37.3.155

A New Treatment Modality Using Topical Sulfasalazine for Oral Lichen Planus  

Jeong, Sung-Hee (Department of Oral Medicine, School of Dentistry, Pusan National University)
Park, Su-Hyeon (Department of Oral Medicine, School of Dentistry, Pusan National University)
Ok, Soo-Min (Department of Oral Medicine, School of Dentistry, Pusan National University)
Heo, Jun-Young (Department of Oral Medicine, School of Dentistry, Pusan National University)
Ko, Myung-Yun (Department of Oral Medicine, School of Dentistry, Pusan National University)
Ahn, Yong-Woo (Department of Oral Medicine, School of Dentistry, Pusan National University)
Publication Information
Journal of Oral Medicine and Pain / v.37, no.3, 2012 , pp. 155-159 More about this Journal
Abstract
Background Oral lichen planus (OLP) is a chronic inflammatory disease characterized by cell-mediated immune responses, but the exact cause is unknown. Sulfasalazine has shown efficacy in the treatment of cutaneous lichen planus. Objective Our purpose was to assess the usefulness of sulfasalazine in treatment of OLP resistant to corticosteroid therapy. This study provides a new option for controlling OLP symptoms. Methods Two patients with the symptomatic reticular form of OLP were treated with 30 mg/5 ml of topical sulfasalazine for 8 to 15 weeks and were evaluated for symptom severity using a numerical analog scale during each week of treatment. The lesion size was measured using a 2 $mm^2$ grid. Results After 2 weeks of application, both patients reported improvements in their symptoms and lesions. Most of the lesions disappeared after 8 weeks of treatment without any side effects. Conclusion Topical sulfasalazine can be a successful treatment option for patients with oral lichen planus resistant to steroid therapy.
Keywords
Oral lichen planus; Resistant to corticosteroid; Sulfasalazine; Topical application;
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