Browse > Article
http://dx.doi.org/10.14476/jomp.2012.37.3.147

Minimally Invasive Laser-Assisted Biopsy of the Oral Lesions for Oral Graft-Versus-Host Disease after Hematopoietic Stem-Cell Transplantation  

Kim, Yun-Mi (Department of Advanced General Dentistry, College of Dentistry, Yonsei University)
Yun, Hee-Jung (Department of Advanced General Dentistry, College of Dentistry, Yonsei University)
Kim, Hyun-Sil (Department of Oral Pathology, College of Dentistry, Yonsei University)
Kim, Kee-Deog (Department of Advanced General Dentistry, College of Dentistry, Yonsei University)
Jung, Bock-Young (Department of Advanced General Dentistry, College of Dentistry, Yonsei University)
Pang, Nan-Sim (Department of Advanced General Dentistry, College of Dentistry, Yonsei University)
Park, Won-Se (Department of Advanced General Dentistry, College of Dentistry, Yonsei University)
Publication Information
Journal of Oral Medicine and Pain / v.37, no.3, 2012 , pp. 147-154 More about this Journal
Abstract
Hematopoietic stem-cell transplantation (HSCT) is a treatment for immune deficiency, autoimmune diseases, and hematopoietic malignancies. The main complication of allogenic HSCT is graft-versus-host disease (GVHD). Oral mucosal biopsy is needed for a definitive diagnosis and treatment planning of GVHD, but this procedure causes bleeding and bacteremia in a poor general condition. We evaluated the efficacy of laser-assisted biopsy as a minimally invasive treatment. Three cases were described in this article. All patients' medical records, clinical photographs, and histopathologic findings were reviewed. All patients felt comfortable and no severe complications occurred. The quality of the obtained biopsy material was adequate for a definitive diagnosis of GVHD. Laser-assisted, minimally invasive biopsy of the oral mucosa does not cause bleeding, and it reduces the chances of infection, bacteremia, and postoperative scarring compared to the usual histopathologic biopsy procedure. It would thus be advantageous to use this procedure to biopsy GVHD patients.
Keywords
Allogenic bone marrow transplantation; Biopsy; Graft vs Host Disease; Er,Cr:YSGG lasers;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Lee SJ, Vogelsang G, Gilman A et al. A survey of diagnosis, management, and grading of chronic GVHD. Biol Blood Marrow Transplant 2002; 8(1):32-39.   DOI   ScienceOn
2 Asai T. Burn in the mouth during oral laser surgery. Anaesthesia 1997; 52(8):806-807.
3 Bradley PF. A review of the use of the neodymium YAG laser in oral and maxillofacial surgery. Br J Oral Maxillofac Surg 1997; 35(1):26-35.   DOI   ScienceOn
4 Deppe H, Horch HH. Laser applications in oral surgery and implant dentistry. Lasers Med Sci 2007; 22(4):217-221.   DOI
5 Sohn DS, Lee JS, An KM, Romanos GE. Erbium, chromium:yttrium-scandium-gallium-garnet laserassisted sinus graft procedure. Lasers Med Sci 2009; 24(4):673-677.   DOI
6 Apel C, Meister J, Ioana RS, Franzen R, Hering P, Gutknecht N. The ablation threshold of Er:YAG and Er:YSGG laser radiation in dental enamel. Lasers Med Sci 2002; 17(4):246-252.   DOI
7 Harashima T, Kinoshita J, Kimura Y et al. Morphological comparative study on ablation of dental hard tissues at cavity preparation by Er:YAG and Er,Cr:YSGG lasers. Photomed Laser Surg 2005; 23(1):52-55.   DOI   ScienceOn
8 Ishii J, Fujita K, Komori T. Laser surgery as a treatment for oral leukoplakia. Oral Oncol 2003; 39(8): 759-769.   DOI   ScienceOn
9 Ishikawa I, Aoki A, Takasaki AA. Potential applications of Erbium:YAG laser in periodontics. J Periodontal Res 2004; 39(4):275-285.   DOI   ScienceOn
10 Zaffe D, Vitale MC, Martignone A, Scarpelli F, Botticelli AR. Morphological, histochemical, and immunocytochemical study of CO2 and Er:YAG laser effect on oral soft tissues. Photomed Laser Surg 2004; 22(3):185-189.   DOI   ScienceOn
11 Ball LM, Egeler RM. Acute GvHD: pathogenesis and classification. Bone Marrow Transplant 2008; 41 Suppl 2:S58-64.   DOI   ScienceOn
12 Nakamura S, Hiroki A, Shinohara M et al. Oral involvement in chronic graft-versus-host disease after allogeneic bone marrow transplantation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996; 82(5):556-563.   DOI   ScienceOn
13 Soares AB, Faria PR, Magna LA et al. Chronic GVHD in minor salivary glands and oral mucosa: histopathological and immunohistochemical evaluation of 25 patients. J Oral Pathol Med 2005; 34(6):368-373.   DOI   ScienceOn
14 Schubert MM, Correa ME. Oral graft-versus-host disease. Dent Clin North Am 2008; 52(1):79-109, viii-ix.   DOI   ScienceOn
15 Demarosi F, Lodi G, Carrassi A, Moneghini L, Sarina B, Sardella A. Clinical and histopathological features of the oral mucosa in allogeneic haematopoietic stem cell transplantation patients. Exp Oncol 2007; 29(4):304-308.
16 Imanguli MM, Alevizos I, Brown R, Pavletic SZ, Atkinson JC. Oral graft-versus-host disease. Oral Dis 2008; 14(5):396-412.   DOI   ScienceOn
17 Shulman HM, Kleiner D, Lee SJ et al. Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group Report. Biol Blood Marrow Transplant 2006; 12(1):31-47.
18 Treister NS, Woo SB, O'Holleran EW, Lehmann LE, Parsons SK, Guinan EC. Oral chronic graft-versushost disease in pediatric patients after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2005; 11(9):721-731.   DOI   ScienceOn
19 Ferrara JL, Levine JE, Reddy P, Holler E. Graft-versus-host disease. Lancet 2009; 373(9674): 1550-1561.   DOI   ScienceOn
20 Filipovich AH, Weisdorf D, Pavletic S et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant 2005; 11(12):945-956.   DOI   ScienceOn