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http://dx.doi.org/10.7317/pk.2013.37.3.262

Effect of pH-Sensitive P(MAA-co-PEGMA) Hydrogels on Release and Stability of Albumin  

Yang, Juseung (Department of Chemical Engineering, Hongik University)
Kim, Bumsang (Department of Chemical Engineering, Hongik University)
Publication Information
Polymer(Korea) / v.37, no.3, 2013 , pp. 262-268 More about this Journal
Abstract
pH-sensitive P(MAA-co-PEGMA) hydrogel particles were prepared and their feasibility as smart delivery carriers for cosmetic ingredients was evaluated. P(MAA-co-PEGMA) hydrogel particles having an average size of approx. $2{\mu}m$ were synthesized via dispersion photopolymerization. There was a drastic change in the swelling ratio of P(MAA-co-PEGMA) particles at a pH of around 5 due to the ionization of MAA in the hydrogel and as the amount of MAA in the hydrogel increased, the swelling ratio increased at a pH above 5. The P(MAA-co-PEGMA) hydrogel particles showed a pH-sensitive release behavior. Thus, at pH 4 almost none of the albumin permeated through the skin while at pH 6 relatively high skin permeability was obtained. The albumin loaded in the P(MAA-co-PEGMA) hydrogel particles was hardly degraded in the presence of pepsin and its stability was maintained.
Keywords
pH-sensitive; hydrogel particles; albumin stability; smart delivery system; skin permeability;
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