Browse > Article
http://dx.doi.org/10.7317/pk.2012.36.3.326

Paclitaxel Coating on ePTFE Artificial Graft and the Release Behavior  

Lim, Soon-Yong (Department of Polymer Science and Engineering, Kumoh National Institute of Technology)
Kim, Cheol-Joo (Department of Polymer Science and Engineering, Kumoh National Institute of Technology)
Kim, Eun-Jin (Institute of Interventional Medicine, M.I.Tech Co., Ltd.)
Kwon, Oh-Kyoung (Gastric Cancer Center, Kyungpook National University Medical Center)
Kwon, Oh-Hyeong (Department of Polymer Science and Engineering, Kumoh National Institute of Technology)
Publication Information
Polymer(Korea) / v.36, no.3, 2012 , pp. 326-331 More about this Journal
Abstract
In this study, expanded poly(tetrafluoro ethylene) (ePTFE) graft was modified to be used as a hemodialysis vascular access. Biodegradable poly(D,L-lactide-$co$-glycolide) (PLGA) was coated onto the inner surface of ePTFE graft with paclitaxel, which is often used as an anti-cancer agent and for reducing neointimal hyperplasia. Surface characterization before and after PLGA coating was carried out by SEM and ATR-FTIR. Porous sturcture of ePTFE was maintained after coating of PLGA solution. The amounts of coated PLGA and paclitaxel determined by ATR-FTIR and HPLC were 1.96 and 0.263 mg/$cm^2$, respectively. Young's modulus was decreased and tensile strength was increased by PLGA coating. Released paclitaxel as a function of incubation time was monitored by HPLC. Approximately 35% of coated paclitaxel was released steadily for 4 weeks with the biodegradation of PLGA. From these results, it is expected that the effect of paclitaxel on reducing neointimal hyperplasia and stenosis is maintained for a long time.
Keywords
ePTFE graft; paclitaxel; PLGA; surface modification; drug release;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)  (Related Records In Web of Science)
연도 인용수 순위
1 T. G. Park, Biomaterials, 16, 1123 (1995).   DOI   ScienceOn
2 T. G. Park, W. Lu, and G. Crotts, J. Control. Release, 33, 211 (1995).
3 T. G. Park and J.-J. Yoon, Polym. Sci. Tech., 10, 722 (1999).
4 I. Baek, Y. J. Lee, S. J. Park, C. Z. Bai, J.-S Park, and D. J. Kim, Bull. Korean Chem. Soc., 31, 281 (2010).   DOI   ScienceOn
5 R. Y. Kanterman, T. M. Vesely, T. K. Pilgram, B. W. Guy, D. W. Windus, and D. Picus, Radiology, 195, 135 (1995).   DOI
6 M. Z. Amin and T. M. Vesely, J. Vasc. Interv. Radiol., 15, 589 (2004).   DOI   ScienceOn
7 A. J. Sorom, C. B. Hughes, J. T. McSarthy, B. M. Jenson, M. Prieto, J. M. Panneton, S. Sterioff, M. D. Stegall, and S. L. Nyberg, Surgery, 132, 135 (2002).   DOI   ScienceOn
8 E. Grube, S. Silber, K. E. Hauptmann, R. Mueller, L. Buellesfeld, U. Gerckens, and M. E. Russell, Circulation, 107, 38 (2003).   DOI   ScienceOn
9 A. Colombo, J. Drzewiecki, A. Banning, E. Grube, K. Hauptmann, S. Silber, D. Dudek, S. Fort, F. Schiele, K. Zmudka, G. Guagliumi, and M. E. Russell, Circulation, 108, 788 (2003).   DOI   ScienceOn
10 J. Aoki, A. Colombo, D. Dudek, A. P. Banning, J. Drzewiecki, K. Zmudka, F. Schiele, M. E. Russell, J. Koglin, and P. W. Serruys, Circulation, 112, 3876 (2005).   DOI   ScienceOn
11 G. W. Stone, S. G. Ellis, D. A. Cox, J. Hermiller, C. O'Shaughnessy, J. T. Mann, M. Turco, R. Caputo, P. Bergin, J. Greenberg, J. J. Popma, and M. E. Russell, New Engl. J. Med., 350, 221 (2004).   DOI   ScienceOn
12 K. L. Sullivan, A. Besarab, J. Bonn, M. J. Shapiro, G. A. Gardiner Jr., and M. J. Moritz, Radiology, 186, 867 (1993).   DOI
13 G. W. Stone, S. G. Ellis, D. A. Cox, J. Hermiller, C. O'Shaughnessy, J. T. Mann, M. Turco, R. Caputo, P. Bergin, J. Greenberg, J. J. Popma, and M. E. Russell, Circulation, 109, 1942 (2004).   DOI   ScienceOn
14 G. W Stone, S. G. Ellis, L. Cannon, J. T. Mann, J. D. Greenberg, D. Spriggs, C. O'Shaughnessy, S. DeMaio, P. Hall, J. J. Popma, J. Koglin, and M. E Russell, J. Am. Med. Assoc., 294, 1215 (2005).   DOI   ScienceOn
15 S. S. Lee, J. H. Shin, J. M. Han, C. H. Cho M.-H. Kim, S.-K. Lee, J.-H. Kim, K.-R. Kim, K. M. Shin, Y. H. Won, and H.-Y. Song, Gastrointest. Endosc., 69, 1140 (2009).   DOI   ScienceOn
16 L.-M. Deng, Y.-Z. Wang, K.-K. Yang, X.-L. Wang, Q. Zhou, and S.-D. Ding, Acta Mater., 51, 5871 (2004).
17 T. G. Park, J. Control. Release, 30, 161 (1994).   DOI   ScienceOn
18 American Heart Association 1997 Heart and stroke statistical update: American Heart Association, National Center, Dallas, 1997.
19 B. H. Lee, H. Y. Nam, T. Kwon, S. J. Kim, G. Y. Kwon, H. J. Jeon, H. J. Lim, W. K. Lee, J.-S. Park, J. Y. Ko, and D. J. Kim, Nephrol. Dial. Transpl., 21, 2432 (2006).   DOI   ScienceOn
20 R. Langer and J. P. Vacanti, Science, 260, 920 (1993).   DOI   ScienceOn
21 T. S. Huber J. W. Carter, R. L. Carter, and J. M. Seeger, J. Vasc. Surg., 38, 1005 (2003).   DOI   ScienceOn
22 T. Masaki, R. Rathi, G. Zentner, J. K. Leypoldt, S. F. Mohammad, G. L. Burns, L. Li, Z. Sergey, T. Chirananthavat, S.-J. Kim, S. Kern, J. Holman, S. W. Kim, and A. K. Cheung, Kidney Int., 66, 2061 (2004).   DOI   ScienceOn
23 T. R. Kohler, P. M. Toleikis, D. M. Gravett, and R. L. Avelar, J. Vasc. Surg., 45, 1029 (2007).   DOI   ScienceOn
24 L. Matyas, M. Berry, G. Menyhei, L. Tamas, G. Acsady, P. Cuypers, F. Halmos, A. C. de Vries, V. Forgacs, G. Ingenito, and R. Avelar, Eur. J. Vasc. Endovasc. Surg., 35, 715 (2008).   DOI   ScienceOn
25 B. H. Lee, J. E. Lee, K. W. Lee, H. Y. Nam, H. J. Jeon, Y. J. Sung, J. S. Kim, H. J. Lim, J.-S. Park, J. Y. Ko, and D. J. Kim, Nephrol. Dial. Transpl., 22, 2800 (2007).   DOI   ScienceOn