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http://dx.doi.org/10.7317/pk.2012.36.1.001

Effect of an Excipient on the Formation of PLGA Particles Using Supercritical Fluid  

Jung, In-Il (Department of Chemical and Biomolecular Engineering, Yonsei University)
Haam, Seung-Joo (Department of Chemical and Biomolecular Engineering, Yonsei University)
Lim, Gio-Bin (Department of Chemical Engineering, The University of Suwon)
Ryu, Jong-Hoon (Department of Chemical Engineering, The University of Suwon)
Publication Information
Polymer(Korea) / v.36, no.1, 2012 , pp. 1-8 More about this Journal
Abstract
In this study, we employed hydroxypropyl-${\beta}$-cyclodextrin (HP-${\beta}$-CD) as an excipient to produce poly(lactic-$co$-glycolic acid) (PLGA) fine particles by a supercritical fluid process, called aerosol solvent extraction system (ASES), and investigated the effect of HP-${\beta}$-CD content on the morphology of the particles. The influence of HP-${\beta}$-CD on the drug release characteristics of paclitaxel-loaded PLGA particles was also evaluated. Fine particles were obtained when the HP-${\beta}$-CD content in PLGA/HP-${\beta}$-CD mixtures was greater than 40% and 30%, respectively, for PLGA(75:25) and PLGA(50:50), whereas a film-like precipitate was obtained for lower HP-${\beta}$-CD content. The release rate for paclitaxel loaded PLGA(75:25)/HP-${\beta}$-CD particles was found to increase with HP-${\beta}$-CD content.
Keywords
supercritical fluid; PLGA; cyclodextrin; fine particles; paclitaxel;
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