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Targeted Drug Delivery Carriers Using Folate Conjugated Poly((R)-3-hydroxy butyrate)-Poly(ethylene glycol) Nanoparticles  

Kwon, Seung-Ho (Department of Applied Chemistry & Biological Engineering, Chungnam National University)
Kim, Young-Jin (Department of Applied Chemistry & Biological Engineering, Chungnam National University)
Publication Information
Polymer(Korea) / v.33, no.6, 2009 , pp. 515-519 More about this Journal
Abstract
Biodegradable poly((R)-3-hydroxy butyrate) and poly(ethylene glycol) was conjugated to make amphiphilic di-block copolymer. Folate was conjugated at di-block copolymer to target the cancer cells. Copolymer was ready to form the self-assembled micelle whose size was 125~156 nm in aqueous solution. Griseofulvin as a hydrophobic drug was loaded in nanoparticles. Their loading efficiencies were 35~56%. Hydrophobic drug was continuously released for 24 h. Cell viability test showed that folate attached particles were 10% more efficient than the particles without targeting ligands.
Keywords
PHB; PEG; folate; targeting; drug delivery;
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