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Preparation of Poly(vinylpyrrolidone) Coated Iron Oxide Nanoparticles for Contrast Agent  

Lee Ha Young (Department of Advanced Organic materials Engineering, Chonbuk National University)
Lim Nak Hyun (Department of Polymer Nano Science and Technology, Chonbuk National University)
Seo Jin A (Nanobiomaterials Laboratories, Korea Research Institute of Chemical Technology)
Khang Gilson (Department of Advanced Organic Materials Engineering, Chonbuk National University, Department of Polymer Nano Science and Technology, Chonbuk National University)
Kim Jungahn (Polymer Hybrids Center, Korea Institute of Science and Technology)
Lee Hai Bang (Nanobiomaterials Laboratories, Korea Research Institute of Chemical Technology)
Cho Sun Hang (Nanobiomaterials Laboratories, Korea Research Institute of Chemical Technology)
Publication Information
Polymer(Korea) / v.29, no.3, 2005 , pp. 266-270 More about this Journal
Abstract
Iron oxide nanoparticles were prepared by the thermal decomposition of iron pentacarbonyl (Fe(CO)$_5$) Poly(vinylpyrrolidone) (PVP) was used as surface-modifying agent to control the size of the iron oxide nanoparticles. The crystalline structure of PVP coated iron oxide nanoparticles was determined by XRD. The size of PVP coated iron oxide nanoparticles was determined by TEM and ELS. The particle sizes of PVP coated iron oxide nanoparticles were controlled by adjusting the molar ratio of PVP/Fe (CO)$_5$, solvent and molecular weight of PVP Particle sizes increased with increasing PVP content. Spherical $50\~100$ nm sized iron oxide nanoclusters were produced when dimethylformamide was used as a solvent. And well-defined 10 nm iron oxide nanoparticles were produced in Carbitol. The prepared PVP coated iron oxide nanoparticles exhibited a well-dispersed property in water. The results obtained in this study confirmed the feasibility of the PVP-coated iron oxide nanoparticles as a biomaterial for MRI contrast agent.
Keywords
iron oxide; nanoparticles; MRI contrast agent; thermal decomposition; poly(vinylpyrrolidone);
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