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Synthesis of 7-Hydroxy-4-Oxo-4H-Chromene- and 7-Hydroxychroman-2-Carboxylic Acid N-Alkyl Amides and Their Antioxidant Activities  

Kwak, Jae-Hwan (College of Pharmacy, Chungbuk National University)
Kang, Hae-Eun (College of Pharmacy, Chungbuk National University)
Jung, Jae-Kyung (College of Pharmacy, Chungbuk National University)
Kim, Hwa-Jung (College of Medicine, Dongguk University)
Cho, Jung-Sook (College of Medicine, Dongguk University)
Lee, Hee-Soon (College of Pharmacy, Chungbuk National University)
Publication Information
Archives of Pharmacal Research / v.29, no.9, 2006 , pp. 728-734 More about this Journal
Abstract
A series of 7-hydroxy-4-oxo-4H-chromene- (3a - h) and 7-hydroxychroman-2-carboxylic acid N-alkyl amides (4a - g) were synthesized and their antioxidant activities were evaluated. While compounds 3a - h were less active, compounds 4a - g exhibited more potent inhibition of lipid peroxidation initiated by $Fe^{2+}$ and ascorbic acid in rat brain homogenates. Among them, 7-hydroxychroman-2-carboxylic acid N-alkylamides (4e - g) bearing nonyl, decyl, and undecyl side chain exhibited 3 times more potent inhibition than trolox (1).
Keywords
Antioxidant activity; 7-Hydroxychroman-2-carboxylic acid N-alkyl amides;
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