Browse > Article

A Convergent Synthetic Study of Biologically Active Benzofuran Derivatives  

Hu, Kun (College of Pharmacy, Kyung Hee University)
Jeong, Jin-Hyun (College of Pharmacy, Kyung Hee University)
Publication Information
Archives of Pharmacal Research / v.29, no.6, 2006 , pp. 476-478 More about this Journal
Abstract
In order to construct a benzofuran library, we developed a model study of benzbromarone. Synthesis has been achieved in 53% overall yield, starting from phenol via the key intermediate 2-ethylbenzofuran which was afforded by intramolecular Wittig reaction.
Keywords
Benzbromarone; Benzofuran library; 2-Ethylbenzofuran; Intramolecular Wittig reaction;
Citations & Related Records

Times Cited By Web Of Science : 2  (Related Records In Web of Science)
Times Cited By SCOPUS : 2
연도 인용수 순위
1 Buu-Hoi, N. P., Bisagni, E., Royer, R., and Routier, C., Oxygen, heterocycles. Part VII. spasmolytic ketones in the benzofuran series, and related compounds. J. Chem. Soc., 625-627 (1957)   DOI
2 Hercouet, A. and Le Corre, M., Une nouvelle voie daces aux benzofurannes. Tetrahedron Letters, 23, 2145-2148 (1979)
3 Hercouet, A. and Le Corre, M., Acyloxyalkylidenephosphoranes- III. Etude des ${\omega}$-Acyloxybenzylidenetriphenylphosphoranes. Nouvelle voie Dacces aux benzofurannes. Tetrahedron, 37, 2867-2873 (1981)   DOI   ScienceOn
4 Zhang, D. Y. and Hua, W. Y., Improvement on the synthetic method of Benzbromarone. Jingxi Huagong, 19, 329-331 (2002)
5 Buu-Hoi. N. P., Xuong, and Bac, Oxygen, heterocycles. Part X. the acylation of benzofuran. J. Chem. Soc., 173 (1964)
6 Elks, J. and Ganellin, C. R., Dictionary of Drugs, Chapman and Hall, 1990, 1st edition
7 Morozumi, T. and Komiyama, M., Quantitative analysis on ortho-directing activities of divalent metal salts in hydroxymethylation of phenol by formaldehyde. Journal of Molecular Catalysts, 69, 339-346 (1991)   DOI   ScienceOn