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Inhibitory Effect on TNF-${\alpha}$-Induced IL-8 Production in the HT29 Cell of Constituents from the Leaf and Stem of Weigela subsessilis  

Thuong Phuong Thien (College of Pharmacy, Chungnam National University)
Jin WenYi (College of Pharmacy, Chungnam National University)
Lee JongPill (Korea Food & Drug Administration)
Seong RackSeon (Korea Food & Drug Administration)
Lee Young-Mi (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University)
Seong YeonHee (College of Agriculture and Life Science, Kyungbuk National University)
Song KyungSik (College of Veterinary Medicine, Chungbuk National University)
Bae KiHwan (College of Pharmacy, Chungnam National University)
Publication Information
Archives of Pharmacal Research / v.28, no.10, 2005 , pp. 1135-1141 More about this Journal
Abstract
Twelve compounds were isolated from the MeOH extract of the leaf and stem of the Korean endemic plant Weigela subsessilis L. H. Bailey. Their chemical structures were elucidated on the basis of physicochemical and spectroscopic data and by comparison with those of published literatures. These compounds were identified as three sterols, ${\beta}$-sitosterol acetate (2), ${\beta}$-sitosterol (3), daucosterol (11), eight triterpenoids, squalene (1), ursolic acid (4), ilekudinol A (5), corosolic acid (6), ilekudinol B (7), esculentic acid (8), pomolic acid (9), asiatic acid (10), and one iridoid glycoside, alboside I (12). This is the first report pertaining to the isolation of these compounds from Weigela subsessilis L. H. Bailey. In addition, three compounds 7, 9, and 12 were found to display a strong inhibitory effect on the production of IL-8 in the HT29 cells stimulated by TNF-${\alpha}$.
Keywords
Weigela subsessilis; Sterols; Triterpenoids; Iridoid glycoside;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 8  (Related Records In Web of Science)
Times Cited By SCOPUS : 9
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