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New Cytotoxic Benzopyrans from the Leaves of Mallotus apelta  

Kiem Phan Van (Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology)
Dang Nguyen Hai (Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology)
Bao Ha Viet (Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology)
Huong Hoang Thanh (Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology)
Minh Chau Van (Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology)
Huong Le Mai (Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology)
Lee Jung Joon (Korea Research Institute of Bioscience and Biotechnology)
Kim Young Ho (College of Pharmacy, Chungnam National University)
Publication Information
Archives of Pharmacal Research / v.28, no.10, 2005 , pp. 1131-1134 More about this Journal
Abstract
Two new benzopyrans 6-[1'-oxo-3'(R)-hydroxy-butyl]-5,7 -dimethoxy-2,2-dimethyl-2H-1-ben-zopyran (1) and 6-[1'-oxo-3'(R)-methoxy-butyl]-5,7 -dimethoxy-2,2-dimethyl-2H-1-benzopyran (2) were isolated from the leaves of Mallotus apelta Muell.-Arg., (Euphorbiaceae). Their chemical structures were elucidated by spectroscopic analyses, especially by 1D-, 2D-NMR and MS spectra. Compound 1 was found to have strong cytotoxic effect against two human cancer cell lines as human hepatocellular carcinoma (Hep-2, $IC_{50}\;:\;0.49\;{\mu}g/mL$) and rhabdosarcoma (RD, $IC_{50}\;:\;0.54\;{\mu}g/mL$), while compound 2 showed moderate activity against Hep-2 cell line ($IC_{50}\;:\;4.22\;{\mu}g/mL$) by in vitro assay.
Keywords
Euphorbiaceae; Mallotus apelta; Benzopyran; Cytotoxic activity;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 3  (Related Records In Web of Science)
Times Cited By SCOPUS : 6
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1 An, T. Y., Hu, L. H., Cheng, X. F., and Chen, Z. L., Benzopyran derivatives from Maflotus apelta. Phytochemistry, 57, 273-278 (2001)   DOI   ScienceOn
2 An, T. Y., Hu, L. H., Cheng, X. F., and Chen, Z. L., Two new benzopyran derivatives from Maflotus apelta. Nat. Prod. Res., 17, 325-328 (2003)   DOI   ScienceOn
3 Cheng, X. F., Meng, Z. M., and Chen, Z. L., A pyridine-type alkaloid from Mallotus apelta. Phytochemistry, 49, 2193-2194 (1998)   DOI   ScienceOn
4 Hori, K., Satake, T., Saiki, Y., and Murakami, K., Chemical and chemotaxonomical studies of Filices. LXXIX. An acylphloro-glucinol glycoside from Diplezium nipponicum TAGAWA. Yakugaku Zasshi, 110, 315-320 (1990)
5 Kamperdick, C., Van, N. H., Sung, T. V., and Adam, G., Benzopyrans from Melicope ptelefolia leaves. Phytochemistry, 45, 1049-1056 (1997)   DOI   ScienceOn
6 Shan, X. Q. and Feng, L. B., Chemical constituents of the roots of Mallotus apelta (Lour.) Muell-Arg.Acta Botanica Sinica, 27, 192-195 (1985)
7 Loi, D. T. (ed.), 'Glossary of Vietnamese Medicinal Plants'. Hanoi S&T Pub., 2001
8 Ono, K., Nakane, H., Meng, Z. M., Ose, Y., Sakai, Y., and Mizuno, M., Differential inhibitory effects of various herb extracts on the activities of reverse transcriptase and various deoxyribonucleic acid (DNA) polymerases. Chem. Pharm. Bull., 37, 1810-1812 (1989)   DOI   ScienceOn
9 Chi, V. V. (ed.), 'Vietnamese Medical Plant Dictionary'. Ha Noi Medicine Pub., 1997
10 Kiem, P. V., Minh, C. V., Huong, H. T., Nam, N. H., Lee, J. J., and Kim, Y. H., Pentacyclic triterpenoids from Mallotus apelta. Arch. Pharm. Res., 27, 1109-1113 (2004)   DOI   ScienceOn
11 Lee, H. J., Park, S. Y., Kim, J. S., Song, H. M., Suh, M. E., and Lee, C. O., Synthesis and cytotoxicity evaluation of pyridin 2,3-f indole-2,4,9-trione and benz f indole-2,4,9-trione derivaties. Bioorg. Med. Chem., 11, 4791-4796 (2003)   DOI   ScienceOn
12 Cheng, X. F., Chen, Z. L., and Meng, Z. M., Two new diterpenoids from Mallotus apelta. J. Asian Nat. Prod. Res., 1, 163-168 (1999a)   DOI   ScienceOn
13 Zhao, J., Wang, X., and Zhang, X., The study on the antioxidant effect of root of Mallotus apelta in the rat model of liver fibrosis. Zhong Yao Cai, 25, 185-187 (2002)
14 Cheng, X. F. and Chen, Z. L., Coumarinofignoids of Maflotus apelta.Fitoterapia, 71, 341-342 (2000)   DOI   ScienceOn
15 Likhitwitayawuid K., Angerhofer C. K., Cordell G. A., and Pezzuto J. M., Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Stephania erecta. J. Nat. Prod., 56, 30-38 (1993)   DOI   PUBMED
16 Cheng, X. F. and Chen, Z. L., Three new diterpenoids from Mallotus apelta. J. Asian Nat. Prod. Res., 1, 319-325 (1999b)   DOI   ScienceOn