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Tungtungmadic Acid, a Novel Antioxidant, from Salicornia her-bacea  

Chung Young-Chul (Division of Food Science, Chinju International University)
Chun Hyo-Kon (Korea Research Institute of Bioscience and Biotechnology)
Yang Jae-Young (Korea Research Institute of Bioscience and Biotechnology)
Kim Ji-Young (Department of Pharmacy, College of Pharmacy, and Research Center for Proteineous Materials, Chosun University)
Han Eun-Hee (Department of Pharmacy, College of Pharmacy, and Research Center for Proteineous Materials, Chosun University)
Kho Yung-Hee (Korea Research Institute of Bioscience and Biotechnology)
Jeong Hye-Gwang (Department of Pharmacy, College of Pharmacy, and Research Center for Proteineous Materials, Chosun University)
Publication Information
Archives of Pharmacal Research / v.28, no.10, 2005 , pp. 1122-1126 More about this Journal
Abstract
Tungtungmadic acid (3-caffeoyl-4-dihydrocaffeoyl quinic acid) is a new chlorogenic acid derivative that was isolated from the Salicomia herbacea. The structure of tungtungmadic acid was determined using chemical and spectral analysis. The antioxidant activity of tungtungmadic acid was evaluated using various antioxidant assays, including free radical scavenging, lipid peroxidation and hydroxyl radical-induced DNA strand breaks assays. Tungtungmadic acid ($IC_{50}\;=\;5.1\;{\mu}M\;and\;9.3\;{\mu}M$) was found to have higher antioxidant activity in the DPPH scavenging assay as well as in the iron-induced liver microsomal lipid peroxidation system. In addition, the tungtungmadic acid was also effective in protecting the plasmid DNA against strand breakage induced by hydroxyl radicals.
Keywords
Salicornia herbacea; 3-Caffeoyl-4-dihydrocaffeoyl quinic acid; Tungtungmadic acid; Antioxidant activity;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 10  (Related Records In Web of Science)
Times Cited By SCOPUS : 14
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