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Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, by Dalbergiae Lignum  

Yin, Hu-Quan (College of Pharmacy and MeRRI, Wonkwang University)
Lee, Bang-Wool (College of Pharmacy and MeRRI, Wonkwang University)
Kim, Youn-Chul (College of Pharmacy and MeRRI, Wonkwang University)
Sohn, Dong-Hwan (College of Pharmacy and MeRRI, Wonkwang University)
Lee, Byung-Hoon (College of Pharmacy and MeRRI, Wonkwang University)
Publication Information
Archives of Pharmacal Research / v.27, no.9, 2004 , pp. 919-922 More about this Journal
Abstract
The effect of an extract of Dalbergiae Lignum and four components that were isolated from the extract on the anticarcinogenic phase II marker enzyme, quinone reductase (QR), was investi-gated. Of the solvent extracts of Dalbergiae Lignum, the CH$_2$CI$_2$ fraction was the most potent in inducing QR activity, with a CD value (the concentration required to double the QR activity) of 29.5 $\mu$/mL. The CH$_2$CI$_2$ extract was further separated into six compounds, four of which were identified as 4-methoxydalbergione, latifolin, 4＇,6-dihydroxy-7-methoxyflavanone, and obtusafu-ran. Obtusafuran ［CD ＝ 1.1 $\mu$M； chemopreventive index (CI) ＝ 101.9］ and latifolin (CD ＝ 1.7 $\mu$M； CI ＝ 154.6) displayed potent QR inducing activity and high chemopreventive indices. Lati-folin and 4-methoxydalbergione were identified as strong DPPH-scavengers with half-maximal free radical scavenging concentrations of 15.9 and 17.2 $\mu$M, respectively.
Keywords
Dalbergiae lignum; Obtusafuran, Latifolin; Quinone reductase; DPPH; Chemoprevention;
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