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Synthesis and Antitubercular Activity of 6-Chloro (Unsubstituted)- 2-Methoxy-9-Substituted Acridine Derivatives  

Aly, Enayat I. (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University)
Abadi, Ashraf H. (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University)
Publication Information
Archives of Pharmacal Research / v.27, no.7, 2004 , pp. 713-719 More about this Journal
Abstract
Several analogues of the general formulae 2-methoxy-9-substituted acridine and 6-chloro-2-methoxy-9-substituted acridine were synthesized and evaluated in vitro at 6.25 $\mu\textrm{g}$/mL against M. tuberculosis $H_{37}Rv$. Compounds 15 and 17 showed potential antitubercular activity with 100％ inhibition to the virulent mycobacterium.
Keywords
Acridine; Tuberculosis;
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