Browse > Article

Anti-Oxidant Activities of Fucosterol from the Marine Algae Pelvetia siliquosa  

Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University)
Lee, Yeon-Sil (Seokwon Life Science Research Institute, World Sea Green Co. Ltd.)
Jung, Sang-Hoon (Natural Products Research Institute, Seoul National University)
Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
Shin, Kuk-Hyun (Seokwon Life Science Research Institute, World Sea Green Co. Ltd.)
Publication Information
Archives of Pharmacal Research / v.26, no.9, 2003 , pp. 719-722 More about this Journal
Abstract
The anti-oxidant activities of fucosterol isolated from the marine algae Pelvetia siliquosa were investigated. Fucosterol exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by $CCl_4$-intoxication in rats. Fucosterol inhibited the sGOT and sGPT activities by 25.57 and 63.16%, respectively. Fucosterol showed the increase in the anti-oxidant enzymes such as hepatic cytosolic superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-px) activities by 33.89, 21.56 and 39.24%, respectively, in $CCl_4$-intoxicated rats. These results suggest that fucosterol possess not only the anti-oxidant, but also the hepatoprotective activities in rats.
Keywords
Pelvetia siliquosa; Fucaceae; Fucosterol; Anti-oxidant enzymes; s-Transaminases $CCl_4-intoxication$;
Citations & Related Records

Times Cited By Web Of Science : 14  (Related Records In Web of Science)
Times Cited By SCOPUS : 15
연도 인용수 순위
1 Cross, C. E., Oxygen radicals and human disease. Ann. Intern. Med., 107, 526-545 (1987)   DOI   PUBMED   ScienceOn
2 Tang, H. F., Yang-Hua, Y., Yao, X. S., Xu, Q. Z., Zhang, S. Y., and Lin, H. W., Bioactive steroids from the brown alga Sargassum carpophyllum. J. Asian Nat. Prod. Res., 4, 95-101 (2002)   DOI   ScienceOn
3 Cerutti, P. A., Oxidant stress and carcinogenesis. Eur. J. Clin. Invest., 21, 1-11 (1991)   DOI   PUBMED   ScienceOn
4 Ikeda, I., Tanaka, K., Sugano, M., Vahouny, G. V., and Gallo, L. L., Inhibition of cholesterol absorption in rats by plant sterols. J. Lipid Res., 29, 1573-1582 (1988)   PUBMED
5 Oh, Y. S., Lee, I. K., and Boo, S. M., An annotated account of Korean economic seaweeds for food, medical and industrial uses. Kor. J. Phycol., 5, 57-71 (1990)
6 Beckman, K. B. and Ames, B. N., The free radical theory of aging matures. Physiol. Rev., 78, 547-581 (1998)   DOI   PUBMED
7 Lowry, O. H., Posenbrough, N. N., Farr, A. L., and Randall, R. J., Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265-275 (1951)   PUBMED
8 Yoon, J. T., Developmental morphology on the regeneration of Pelvetia siliquosa Tseng et Chang, Phaeophyta in Korea. Chonbuk National University. Ph. D. Thesis (1995)
9 Atta-ur-Rahman, Choudhary, M. I., Hayat, S., Khan, A. M., Ahmad, and A., Malik, S., Spatozoate and verninasterol from the brown alga Spatoglossum variabile. Phytochemistry, 52, 495-499 (1999)   DOI   ScienceOn
10 Recknagel, R. O., Glende Jr., E. A., Dolak, J. A., and Waller, R. L., Mechanisms of carbon tetrachloride toxicity. Pharmacol. Therapeut., 43, 139-154 (1989)   DOI   ScienceOn
11 Atta-ur-Rahman, Choudhary, M. I., Majeed, A., Shabbir, M., Ghani, U., and Shameel, M., A succinylanthranilic acid ester and other bioactive constituents of Jolyna laminarioides. Phytochemistry, 46, 1215-1218 (1997)   DOI   PUBMED
12 Burk, R. F., Nishiki, K., Lawrence, R. A., and Chance, B., Peroxide removal by selenium-dependent and selenium-independent glutathione peroxidases in hemoglobin free perfused rat liver. J. Biol. Chem., 253, 43-46 (1978)   PUBMED
13 McCord, J. M. and Fridovich, I., Superoxide dismutase: An enzymatic function for erythrocuprein (hemocoprein). J. Biol. Chem., 244, 6049-6055 (1969)   PUBMED
14 Hagiwara, H., Wakita, K., Inada, Y., and Hirose, S., Fucosterol decreases angiotensin converting enzyme levels with reduction of glucocorticoid receptors in endothelial cells. Biochem. Biophys. Res. Commun., 139, 348-352 (1986)   DOI   ScienceOn
15 Rigo, A. and Rotilio, G., Simultaneous determination of superoxide dismutase and catalase in biological materials by polarography. Anal. Biochem., 81, 157-166 (1977)   DOI   ScienceOn
16 Pike, J. and Chandra, R. K., Effect of vitamin and trace element supplementation on immune indices in healthy elderly. Int. J. Vitamin Nutr. Res., 65, 117-120 (1995)
17 Lee, Y. S., Jung, S. H., Lee, S., Choi, Y. J., and Shin, K. H., Hepatoprotective and anti-diabetic effects of Pelvetia siliquosa, a marine algae, in rats. J. Appl. Pharmacol., 10, 165-169 (2002)
18 Reitman, S. and Frankel, S., A chlorotrimetric method for the determination of sGOT and sGPT. Am. J. Clin. Pathol., 28, 56-63 (1957)   DOI   PUBMED
19 Kumaravelu, P., Dakshinamoorthy, D. P., Subramaniam, S., Devaraj, H., and Devaraj, N. S., Effect of eugenol on drugmetabolizing enzymes of carbon tetrachloride-intoxicated rat liver. Biochem. Pharmacol., 49, 17031707 (1995)   DOI   ScienceOn