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Pheophorbide A-methyl Ester, Acyl-CoA: Cholesterol Acyltransferase Inhibitor from Diospyros kaki  

Rho, Mun-Chual (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology)
Chung, Mi-Yeon (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology)
Song, Hye-Young (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology)
Kwon, Oh-Eok (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology)
Lee, Seung-Woong (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology)
Baek, Jin-Ah (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology)
Jeune, Kyung-Hee (Department of Biology, Yeungnam University)
Kim, Koan-Hoi (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology)
Lee, Hyun-Sun (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology)
Kim, Young-Kook (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology)
Publication Information
Archives of Pharmacal Research / v.26, no.9, 2003 , pp. 716-718 More about this Journal
Abstract
In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an $IC_{50}$ value of 1.85 $\mu$ g/mL.
Keywords
Acyl-CoA; cholesterol acyltransferase; Pheophorbide A-methyl ester; Diospyros kaki;
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