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Effect of Active Synthetic 2-Substituted Quinazolinones on Anti-Platelet Aggregation and the Inhibition of Superoxide Anion Generation by Neutrophils  

Chang, Fang-Rong (Graduate Institute of Natural Products, Kaohsiung Medical University)
Wu, Chin-Chung (Graduate Institute of Natural Products, Kaohsiung Medical University)
Hwang, Tsong-Long (Graduate Institute of Natural Products, Chang Gung University)
Patnam, Ramesh (Graduate Institute of Natural Products, Kaohsiung Medical University)
Kuo, Reen-Yen (Graduate Institute of Natural Products, Kaohsiung Medical University)
Wang, Wei-Ya (Graduate Institute of Natural Products, Kaohsiung Medical University)
Lan, Yu-Hsuan (Graduate Institute of Natural Products, Kaohsiung Medical University)
Wu, Yang-Chang (Graduate Institute of Natural Products, Kaohsiung Medical University)
Publication Information
Archives of Pharmacal Research / v.26, no.7, 2003 , pp. 511-515 More about this Journal
Abstract
Quinazolinones, 2-substituted and 3-substituted, mainly synthesized by microwave irradiation, were subjected to anti-platelet aggregation and inhibition of superoxide anion generation assays. Interestingly, 2-phenyl-4-quinazolinone (4) exhibited significant inhibitory activities toward platelet aggregation and neutrophil activation, and it might therefore serve as a prototype lead compound.
Keywords
Hydrangea chinensis; Quinazolinones; Anti-platelet aggregation; Superoxide anion generation; Microwave;
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1 Boyum, A., Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest., 97, 77-89 (1968)
2 Mannschreck, A., Koller, H., Stuhler, G., Davies, M. A., and Traber, J., The enantiomers of methaqualone and their unequal anticonvulsive activity. Eur. J. Med. Chem., 19, 381 (1984)
3 Ravikanth, V., Ramesh, P., Diwan, P. V., and Venkateswarlu, Y., Microwave irradiation of embelin and evaluation of antibacterial activity. Heterocycl. Commun., 6, 315-318 (2000)
4 Sharma, S. D. and Kaur, V., Synthesis of 3-oxa- and 3-aza-1-dethiacepham analogs. Synthesis, 9, 677-680 (1989)
5 Cross, A. R., Parkinson, J. F., and Jones, O. T. G., The superoxide-generating oxidase of leucocytes. NADPH-dependent reduction of flavin and cytochrome b in solubilized preparations. Biochem. J., 223, 337-344 (1984)   DOI   PUBMED
6 Malamas, M. S. and Millen, J., Quinazolineacetic acids and related analogs as aldose reductase inhibitors. J. Med. Chem., 34, 1492-1503 (1991)   DOI   PUBMED
7 Murata, K., Takano, F., Fushiya, S., and Oshima, Y., Enhancement of NO production in activated macrophages in vivo by an antimalarial crude drug, Dichroa febrifuga. J. Nat. Prod., 61, 729-733 (1998)   DOI   ScienceOn
8 Kobayashi, S., Ueno, M., Suzuki, R., Ishitani, H., Kim, H. S., and Wataya, Y., Catalytic asymmetric synthesis of antimalarial alkaloids febrifugine and isofebrifugine and their biological activity. J. Org. Chem., 64, 6833-6841 (1999)   DOI   ScienceOn
9 De Laszlo, S. E., Quagliato, C. S., Greenlee, W. J., Patchett, A. A., Chang, R. S. L., Lotti, V. J., Chen, T. B., Scheck, S. A., Faust, K. A., Kivlighn, S. S., Schorn, T. S., Zingaro, G. J., and Siegl, P. K. S., A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor. J. Med. Chem., 36, 3207-3210 (1993)   DOI   ScienceOn
10 Seijas, J. A., Vazquez-Tato, M. P., and Montserrat, M. M., Microwave enhanced synthesis of 4-aminoquinazolines. Tetrahedron Lett., 41, 2215-2217 (2000)   DOI   ScienceOn
11 Wu, C. C., Huang, S. W., Hwang, T. L., Kuo, S. C., Lee, F. Y., and Teng, C. M., YD-3, a novel inhibitor of protease-induced platelet activation. Br. J. Pharmacol., 130, 1289-1296 (2000)   DOI   ScienceOn
12 Griffin, R. J., Srinivasan, S., Bowman, K., Calvert, A. H., Curtin, N. J., Newell, D. R., Pemberton, L. C., and Golding, B. T., Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). J. Med. Chem., 41, 5247-5256 (1998)   DOI   ScienceOn
13 Chiang-Su New Medical College, The Dictionary of Chinese Medicine (I). Shanghai Scientific Technology, Shanghai, pp.45, (1978)
14 Seger, C., Vajrodaya, S., Greger, H., and Hofer, O., Structure elucidation and synthesis of a new bioactive quinazolone derivative obtained from Glycosmis cf. chlorosperma. Chem. Pharm. Bull., 46, 1926-1928 (1998)   DOI   ScienceOn