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Cystocin, a Novel Antibiotic, Produced by Streptomyces sp. GCA0001: Biological Activities  

Lee, Hei-Chan (Institute of Biomolecule Reconstruction, Sunmoon University)
Liou, Kwangkyoung (Institute of Biomolecule Reconstruction, Sunmoon University)
Kim, Dae-Hee (GeneChem inc., Daeduk Bio Community)
Kang, Sun-Yub (GeneChem inc., Daeduk Bio Community)
Woo, Jin-Suk (GeneChem inc., Daeduk Bio Community)
Sohng, Jae-Kyung (Institute of Biomolecule Reconstruction, Sunmoon University)
Publication Information
Archives of Pharmacal Research / v.26, no.6, 2003 , pp. 446-448 More about this Journal
Abstract
Cystocin belongs to the class of nucleoside antibiotics from Streptomyces sp. GCA0001. Cystocin showed good activity against Gram-positive bacteria, but showed less activity against the Gram-negative bacteria. Cystocin exhibited about two to four folds higher activity than puromycin. Especially, cystocin shows relatively strong activity against Streptococcus strains. Cystocin shows quite potent antitumor activity against all of the cells tested showing $IC_{50}$ values of 0.10 to 0.14 $\mu$ g/mL. This in vitro result indicates that the cytotoxocity of cystocin is two ten folds more active than puromycin s.
Keywords
Cystocin; 3'-[S-Methyl-cysteinyl]-3'-amino-3'-deoxy-N,N-dimethyladenosine; Puromycin; Antibiotic activity; Streptomyces;
Citations & Related Records

Times Cited By Web Of Science : 4  (Related Records In Web of Science)
Times Cited By SCOPUS : 3
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