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Synthesis of Certain Substituted Quinoxalines as Antimicrobial Agents (Part II)  

Mohga.M.Badran (Department of Organic Chemistry, Faculty of Pharmacy, Cairo University)
Khaled.A.M.Abouzid (Department of Organic Chemistry, Faculty of Pharmacy, Cairo University)
M. H. M. Hussein (Department of Organic Chemistry, Faculty of Pharmacy, Cairo University)
Publication Information
Archives of Pharmacal Research / v.26, no.2, 2003 , pp. 107-113 More about this Journal
Abstract
Several fused triazolo and ditriazoloquinoxaline derivatives such as 1-aryl-4-chloro-[1,2,4]triazolo[4,3-a]quinoxalines (3a-d), 4-alkoxy[1,2,4]triazolo[4,3-a]quinoxalines (4a,b), 4-substituted-amino-[1,2,4] triazolo[4,3-a]quinoxalines (5a-h), 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-thione (6), 4-(arylidenehydrazino )-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalines (10a-e) and [1,2,4]ditriazolo[4,3-a:3',4'-c]quinoxaline derivatives (11-13) have been synthesized and some of these derivatives were evaluated for antimicrobial and antifungal activity in vitro. It was found that compounds 3a and 9b possess potent antibacterial activity compared to the standard tetracycline.
Keywords
Ditriazoloquinoxalines; Triazoloquinoxalines; Triazoloquinoxalinethione; Synthesis; Antibacterial agents;
Citations & Related Records

Times Cited By Web Of Science : 22  (Related Records In Web of Science)
Times Cited By SCOPUS : 21
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