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In Vivo Anti-Oxidant Activities of Tectochrysin  

Lee, Sang-Hyun (College of Pharmacy, Seoul National University, Natural Products Research Institute, Seoul National University)
Kim, Kyoung-Soon (College of Pharmacy, Seoul National University)
Park, You-Mie (College of Pharmacy, Seoul National University)
Shin, Kuk-Hyun (Seokwon Life Science Research Institute)
Kim, Bak-Kwang (College of Pharmacy, Seoul National University)
Publication Information
Archives of Pharmacal Research / v.26, no.1, 2003 , pp. 43-46 More about this Journal
Abstract
The anti-oxidant activities of tectochrysin, a major compound of propolis, were investigated. Tectochrysin exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by $CCl_4$-intoxication in rats. Tectochrysin tested exhibited a lipid peroxidation causing a significant decrease in MDA production in TBA-reactant assay. Tectochrysin was strong in the increase in the anti-oxidant enzymes such as hepatic cytosolic superoxide dismutase, catalase and glutathione peroxidase activities in $CCl_4$-intoxicated rats. These results suggest that tectochrysin possess not only the anti-oxidant, but also the activities in $CCl_4$-intoxicated rats. Especially, tectochrysin was found to cause significant increases in the rat liver cytosolic SOD, catalase, GSH-px activities as well as a significant decrease in the MDA production.
Keywords
Tectochrysin; Anti-oxidant enzymes; Transaminase TBA-reactant assay;
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Times Cited By Web Of Science : 5  (Related Records In Web of Science)
Times Cited By SCOPUS : 2
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