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Epidermis Proliferative Effect of the Panax ginseng Ginsenoside $Rb_2$  

Choi, Seong-Won (Department of Pharmacology, Seoul National University, College of Medicine)
Publication Information
Archives of Pharmacal Research / v.25, no.1, 2002 , pp. 71-76 More about this Journal
Abstract
Ginseng has been used as a traditional medicine with various therapeutic effects. However, it is still unknown which component of this plant is effective at promoting wound healing. Recently, ginsenoside $Rb_2$ has been reported to improve wound healing. In this study, to investigate the reported wound healing effect of the ginsenoside $Rb_2$, cell morphology and protein factors involved in epidermal formation were evaluated by immunshemical and immunoblotting analysis. $Rb_2$ stimulated epidermal cell proliferation, and the cell showed a 1.5-fold increase in thymidine uptake compared to the control (p<0.05, n=3). Futheremore $Rb_2$, was found to stimulate epidermis formation in a dose-dependent manner in raft culture, and to dose dependently enhance the expressions of protein factors related to cell proliferation, namely, epidermal growth factor and its receptor, fibronectin and its receptor, keratin 5/14, and collagenase 1 (p<0.05, n=3~9). It is believed that ginsenoside $Rb_2$, enhances epidermal cell proliferation by upregulating the expressions of these proliferation-related factors.
Keywords
Panax ginseng; Ginsenoside $Rb_2$; Epidermal growth factor; Fibronectin Keratin; Collagenase;
Citations & Related Records

Times Cited By Web Of Science : 10  (Related Records In Web of Science)
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