Browse > Article

Effects of Opuntia ficus-indica var. Saboten Stem on Gastric Damages in Rats  

Lee, Eun-Bang (National Products Research Institute, Seoul National University)
Hyun, Jin-Ee (National Products Research Institute, Seoul National University)
Li, Da-Wei (National Products Research Institute, Seoul National University)
Moon, Yung-In (Pukjeju Agricltural Development and Technology Extension Center)
Publication Information
Archives of Pharmacal Research / v.25, no.1, 2002 , pp. 67-70 More about this Journal
Abstract
The effects of the dried stem powder of Opuntia ficus-indica var. saboten (OF-s) were investigated on gastric lesion and ulcer models in rats. It showed significant inhibition in HCl·ethanolinduced gastric lesion at the doses of 200 and 600 mg/kg p.o. and in HCl·aspirin-induced gastric lesion at 600 mg/kg p.o. OF-s also showed significant inhibition in indomethacin-induced gastric lesion at the doses of 200 and 600 mg/kg, p.o. However, it did not affect both the aspirin-induced and Shay ulcers in rats. It also did not affect gastric juice secretion, acid output and pH. These data indicate that OF-s only possesses pronounced inhibitory action on gastric lesion without antiulcer activity in rats.
Keywords
Opuntia ficus-indica stem; Cactaceae; Antigastric lesion;
Citations & Related Records

Times Cited By Web Of Science : 7  (Related Records In Web of Science)
Times Cited By SCOPUS : 8
연도 인용수 순위
1 Suzuki, K., Araki, H., Komoike, Y., and Takeuchi, K., Permissive role of neutrophils in pathogenesis of indomethacin-induced gastric lesion in rats. Med. Sci. Monit.. 6, 908-914 (2000)   PUBMED
2 Takagi, K., Takeuchi, K., Nakamura, K., Morita, A., and Okabe, S., Effects of an antiulcer agent, N-acetyl-L-glutamine aluminum complex (KW-110) on the duodenal and gastric ulcer models in the rat. Jpn. J. Pharmacol., 24, 357-361 (1974)   DOI   PUBMED
3 Ahmad, A., Davides, J., Randall, S., and Skinner, G. R., Antiviral properties of extract of Opuntia streptacantha. Antiviral Res., 30, 75 (1996)   DOI   ScienceOn
4 Han, Y. N., Choo, Y. S., Lee, Y. C., Moon, Y. I., Kim, S. D., and Choi, J. W., Monoamine oxidase B inhibitors from the fruits of Opuntia ficus-indica var. saboten. Arch. Pharm. Res., 24, 51-54 (2001)   DOI   ScienceOn
5 Ibanez-Camacho, R. and Roman-Ramos, R. Hypoglycemic effect of Opuntia cactus. Arch. Invest. Med. (Mex), 10, 223 (1979)   PUBMED
6 Jiansu New College Medicine Eds. Encyclopedia of Chiness Herbs, Shanghai Science & Technology Publication, Shanghai, pp. 663 (1977)
7 Park, E. H., Kahng, J. H., and Paek, E. A., Stud es on the pharmacological actions of cactus: Identification of its anti-inflammatory effect. Arch. Pharm. Res., 21, 30 (1998)   DOI   PUBMED
8 Jeong, S. J., Jun, K. Y., Kang, T. H., and Ko, E. B. et al., Flavonoids from the fruits of Opuntia ficus-indica var. saboten. Kor. J. Pharmagn., 30, 84-86 (1999)
9 Park, E. H., Kahng, J. H. Lee, S. H., and Shin, K. H., An anti-inflammatory principle from cactus. Fitotherapia, 72, 288-290 (2001)   DOI   ScienceOn
10 Seiki, M., Ukei, S., Tanaka, Y., and Soeda, M., Studies of anti-ulcer effects of a new compound, zinc L-camosine (Z-103). Folia Pharmacol. Japan, 95, 257 (1990)   DOI   ScienceOn
11 Yook, C. S., Saengyak Dogam, Gyoungwon Publ. Co., Seoul, pp. 351, 1996
12 Lee, H. J., Korean flora, Moonkyobu Eds, Seoul, pp. 113, 1964
13 Burret, F., Lebreton, P. H., and Voirin, B., Les aglycones flavoniques de cactees: distribution, signification. J. Nat. Pro., 45, 687-693 (1982)   DOI
14 Galati, E. M., Monforte, M. T, Tripodo, M. M., d'Aquino, A. and Mondello, M. R., Antiulcer activity of Opuntia ficus-indica (L.) Mill. (Cactaceae): ultrastructural study. J. Ethnopharmacol., 76, 1-9 (2001)   DOI   ScienceOn
15 Ahn, D. K., Illustrated book of Korean medicinal herbs, Kyohaksa, Seoul, pp.497, 1998
16 Mizui, T. and Dodeuchi, M., Effect of polyamines on acidified ethanol induced gastric lesion in rats. Jpn. J. Pharmacol., 33, 939-945 (1983)   DOI   PUBMED
17 Guth, P. H., Aures, D., and Paulsen, G., Topical Aspirin Plus HCI Gastric Lesions in the Rat. Gastroenterology, 76, 88 (1979)   PUBMED
18 Takeuch, K. and Ueki, S., importance of gastric motility in the pathogenesis indomethacin-induced gastric lesion in rats. Dig. Dis. Sci., 31, 1114 (1986   DOI   ScienceOn
19 Okabe, S., Takeuchi, K., Nakamura, K., and Takagi, K., Pathogenesis of gastric lesion induced by aspirin in the pylorusligated rat. Jpn. J. Pharmacol., 24, 363 (1974)   DOI   PUBMED
20 Shay, H., Komarov, S. A., Fels, S. S., and Meranze, D., A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology, 4, 43-61 (1945)