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Magnetic and Temperature-Sensitive Composite Polymer Particles and Adsorption Behavior of Emulsifiers and Trypsin  

Ahmad, Hasan (Department of Chemistry, Rajshahi University)
Rahman, M.Abdur (Department of Chemistry, Rajshahi University)
Miah, M.A. Jalil (Department of Chemistry, Rajshahi University)
Tauer, Klaus (MPI of Colloid and Interface, Am Muhlenberg)
Publication Information
Macromolecular Research / v.16, no.7, 2008 , pp. 637-643 More about this Journal
Abstract
A combination of magnetic and temperature-responsive properties in the same polymer composites is expected to increase their potential applications in the biomedical field. Accordingly, micron-sized magnetite/polystyrene/poly(2-dimethylaminoethyl methacrylate-ethyleneglycol dimethacrylate), which are abbreviated as $Fe_3O_4$/PS/P (DM-EGDM) composite polymer particles, were prepared by the seeded copolymerization of DM and EGDM in the presence of magnetite/polystyrene ($Fe_3O_4$/PS) particles. $Fe_3O_4$/PS/P(DM-EGDM) composite particles with magnetic properties showed a temperature-sensitive phase transition at approximately $31^{\circ}C$. The adsorption behavior of the low molecular weight emulsifiers and trypsin (TR) as biomolecules were examined on $Fe_3O_4$/PS/P(DM-EGDM) composite polymer particles at different temperatures. The native conformation of TR was followed by measuring the specific activity under various adsorption conditions. The activity of the adsorbed TR on composite polymer particles was higher than those of the tree TR and TR adsorbed on $Fe_3O_4$/PS particles.
Keywords
$Fe_3O_4$; temperature-sensitive; LCST; TR; specific activity;
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