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http://dx.doi.org/10.5483/BMBRep.2014.47.4.128

HDAC3 acts as a negative regulator of angiogenesis  

Park, Deokbum (Department of Biochemistry, College of Natural Sciences, Kangwon National University)
Park, Hyunmi (Department of Biochemistry, College of Natural Sciences, Kangwon National University)
Kim, Youngmi (Department of Biochemistry, College of Natural Sciences, Kangwon National University)
Kim, Hyuna (Department of Biochemistry, College of Natural Sciences, Kangwon National University)
Jeoung, Dooil (Department of Biochemistry, College of Natural Sciences, Kangwon National University)
Publication Information
BMB Reports / v.47, no.4, 2014 , pp. 227-232 More about this Journal
Abstract
Histone deacetylase-3 (HDAC3) is involved in cellular proliferation, apoptosis and transcriptional repression. However, the role of HDAC3 in angiogenesis remains unknown. HDAC3 negatively regulated the expression of angiogenic factors, such as VEGF and plasminogen activator inhibitor-1 (PAI-1). HDAC3 showed binding to promoter sequences of PAI-1. HDAC3 activity was necessary for the expression regulation of PAI-1 by HDAC3. VEGF decreased the expression of HDAC3, and the down-regulation of HDAC3 enhanced endothelial cell tube formation. HDAC3 negatively regulated tumor-induced angiogenic potential. We show the novel role of HDAC3 as a negative regulator of angiogenesis.
Keywords
Angiogenesis; Angiogenic factors; Anti cancer drug-resistance; Histone deacetylase-3; Tumor-induced angiogenesis;
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Times Cited By KSCI : 4  (Citation Analysis)
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