[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5483/BMBRep.2012.45.11.227

Long noncoding RNA involvement in cancer

Maruyama, Reo (Department of Molecular Biology, Sapporo Medical University)
Suzuki, Hiromu (Department of Molecular Biology, Sapporo Medical University)

Publication Information

BMB Reports / v.45, no.11, 2012 , pp. 604-611 More about this Journal

Abstract

Recent advances in genome and transcriptome analysis have enabled identification of numerous members of a new class of noncoding RNA, long noncoding RNA (lncRNA). lncRNAs are broadly defined as RNA molecules greater than 200 nt in length and lacking an open reading frame. Recent studies provide evidence that lncRNAs play central roles in a wide range of cellular processes through interaction with key component proteins in the gene regulatory system, and that alteration of their cell- or tissue-specific expression and/or their primary or secondary structures is thought to promote cell proliferation, invasion and metastasis. The biological and molecular characteristics of the large majority of lncRNAs remains unknown, and it is anticipated that improved understanding of the roles played by lncRNAs in cancer will lead to the development of novel biomarkers and effective therapeutic strategies.

Keywords

Biomarker; Cancer; Gene regulation; Histone modification; LincRNA; Long noncoding RNA; Oncogene; Tumor suppressor;

Citations & Related Records

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