Discovery of Cyclin-dependent Kinase Inhibitor, CR229, Using Structure-based Drug Screening |
Kim, Min-Kyoung
(Department of Medical Genetics, College of Medicine, Hanyang University)
Min, Jae-Ki (Department of Molecular Biology and Pharmacology, C&C Research Laboratories) Choi, Bu-Young (Department of Molecular Biology and Pharmacology, C&C Research Laboratories) Lim, Hae-Young (Department of Medical Genetics, College of Medicine, Hanyang University) Cho, Youl-Hee (Department of Medical Genetics, College of Medicine, Hanyang University) Lee, Chul-Hoon (Department of Medical Genetics, College of Medicine, Hanyang University) |
1 | Kawanishi, N., T. Sugimoto, J. Shibata, K. Nakamura, K. Masutani, M. Ikuta, and H. Hirai. 2006. Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure. Bioorg. Med. Chem. Lett. 16: 5122-5126 DOI ScienceOn |
2 | Lim, H., Y. Lim, Y.-H. Cho, and C.-H. Lee. 2006. Induction of apoptosis in the HepG2 cells by HY53, a novel natural compound isolated from Bauhinia forficata. J. Microbiol. Biotechnol. 16: 1262-1268 과학기술학회마을 |
3 | Lim, H., H. L. Oh, and C.-H. Lee. 2006. Effect of Aralia continentalis root extract on cell proliferation and apoptosis in human promyelocytic leukemia HL-60 cells. J. Microbiol. Biotechnol. 16: 1399-1404 과학기술학회마을 |
4 | Shapiro, G. I. 2006. Cyclin-dependent kinase pathways as targets for cancer treatment. J. Clin. Oncol. 24: 1770-1783 DOI ScienceOn |
5 | Sherr, C. J. 1993. Mammalian G1 cyclins. Cell 73: 1059-1065 |
6 | Takizawa, C. G. and D. O. Morgan. 2000. Control of mitosis by changes in the subcellular location of cyclin-B1-CDK1 and Cdc25C. Curr. Opin. Cell Biol. 12: 658-665 DOI ScienceOn |
7 | Vulpetti, A., E. Casale, F. Roletto, R. Amici, M. Villa, and P. Pevarello. 2006. Structure-based drug design to the discovery of new 2-aminothiazole CDK2 inhibitors. J. Mol. Graph. 24: 341-348 DOI ScienceOn |
8 | Gray, N., L. Detivaud, C. Doerig, and L. Meijer. 1999. ATPsite directed inhibitors of cyclin-dependent kinases. Curr. Med. Chem. 6: 859-875 |
9 | Kim, M. K., Y.-H. Cho, J. M. Kim, M. W. Chun, S. K. Lee, Y. Lim, and C.-H. Lee. 2005. Induction of apoptosis in human leukemia cells by MCS-C2 via caspase-dependent Bid cleavage and cytochrome c release. Cancer Lett. 223: 239-247 DOI ScienceOn |
10 | Lim, H., M. K. Kim, Y. Lim, Y.-H. Cho, and C.-H. Lee. 2006. Inhibition of cell-cycle progression in HeLa cells by HY52, a novel cyclin-dependent kinase inhibitor isolated from Bauhinia forficata. Cancer Lett. 233: 89-97 DOI ScienceOn |
11 | Knockaert, M., P. Greengard, and L. Meijer. 2002. Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol. Sci. 23: 417-425 DOI ScienceOn |
12 | Kakizaki, I., K. Ookawa, T. Ishikawa, M. Hayakari, T. Aoyagi, and S. Tsuchida. 2000. Induction of apoptosis and cell cycle arrest in mouse colon 26 cells by benastatin A. Cancer Sci. 91: 1161-1168 DOI |
13 | Vakser, I. A. and C. Aflalo. 1994. Hydrophobic docking: A proposed enhancement to molecular recognition techniques. Proteins 20: 320-329 DOI ScienceOn |
14 | Desjarlais, R. L. 1997. Generation and use of threedimensional databases for drug discovery, pp. 73-104. In P. S. Charifson (ed.), Practical Application of Computer-aided Drug Design. Marcel Dekker, New York, U.S.A |
15 | Choi, Y. H., W. H. Lee, K. Y. Park, and L. Zhang. 2000. p53- independent induction of p21 (WAF1/CIP1), reduction of cyclin B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells. Cancer Sci. 91: 164-173 DOI |
16 | Kim, H. J. and H. J. Kwon. 2007. Synthesis and biological activity of fungal metabolite, 4-hydroxy-3-(3'-methyl-2'-butenyl)-benzoic acid. J. Microbiol. Biotechnol. 17: 543-545 과학기술학회마을 |
17 | Schang, L. M., A. Rosenberg, and P. A. Schaffer. 2000. Roscovitine, a specific inhibitor of cellular cyclin-dependent kinases, inhibits herpes simplex virus DNA synthesis in the presence of viral early proteins. J. Virol. 74: 2107-2120 DOI |
18 | Lim, H., M. K. Kim, Y.-H. Cho, J. M. Kim, Y. Lim, and C.-H. Lee. 2004. Inhibition of cell cycle progression and induction of apoptosis in HeLa cells by HY558-1, a novel CDK inhibitor isolated from Penicillium minioluteum F558. J. Microbiol. Biotechnol. 14: 978-984 |
19 | Obaya, A. J. and J. M. Sedivy. 2002. Regulation of cyclin- CDK activity in mammalian cells. Cell. Mol. Life Sci. 59: 126-142 DOI |
20 | Davis, S. T., B. G. Benson, H. N. Bramson, D. E. Chapman, S. H. Dickerson, K. M. Dold, D. J. Eberwein, M. Edelstein, S. V. Frye, R. T. Gampe, R. J. Grifffen, P. A. Harris, A. M. Hassell, W. D. Holmes, R. N. Hunter, V. B. Knick, K. Lackey, B. Lovejoy, M. J. Luzzio, D. Murray, P. Parker, W. J. Rocgue, L. Shewchuk-Chapman, J. M. Veal, D. H. Walker, and L. F. Kuyper. 2001. Prevention of chemotherapyinduced alopecia in rats by CDK inhibitors. Science 291: 134-137 DOI ScienceOn |
21 | Doerig, C., L. Meijer, and J. C. Mottram. 2002. Protein kinases as drug targets in parasitic protozoa. Trends Parasitol. 18: 366-371 DOI ScienceOn |
22 | Honma, T., K. Hayashi, T. Aoyama, N. Hashimoto, T. Machida, K. Fukasawa, T. Iwama, C. Ikeura, M. Ikuta, I. Suzuki-Takahashi, Y. Iwasawa, T. Hayama, S. Nishimura, and H. Morishima. 2001. Structure-based generation of a new class of potent Cdk4 inhibitors: New de novo design strategy and library design. J. Med. Chem. 44: 4615-4627 DOI ScienceOn |
23 | Kim, H. J., J. H. Kim, C. H. Lee, and H. J. Kwon. 2006. Gentisyl alcohol, an antioxidant from microbial metabolite, induces angiogenesis in vitro. J. Microbiol. Biotechnol. 16: 475-479 과학기술학회마을 |
24 | Osuga, H., S. Osuga, F. Wang, R. Fetni, M. J. Hogan, R. S. Stack, A. M. Hakim, J. E. Ikeda, and D. S. Park. 2000. Cyclin-dependent kinases as a therapeutic target for stroke. Proc. Natl. Acad. Sci. USA 97: 10254-10259 |
25 | Sherr, C. J. 1996. Cancer cell cycle. Science 274: 1672-1677 DOI ScienceOn |
26 | Wang, D., C. de la Fuente, L. Deng, L. Wang, I. Zilberman, C. Eadie, M. Healey, D. Stein, T. Denny, L. E. Harrison, L. Meijer, and F. Kashanchi. 2001. Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors. J. Virol. 75: 7266-7279 DOI ScienceOn |
27 | Park, H. Y., M. K. Kim, S. I. Moon, Y.-H. Cho, and C.-H. Lee. 2006. Cell cycle arrest and apoptotic induction in LNCaP cells by MCS-C2, novel cyclin-dependent kinase inhibitor, through pathway. Cancer Sci. 97: 430-436 DOI ScienceOn |
28 | Sherr, C. J. and J. M. Roberts. 1999. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev. 13: 1501-1512 DOI ScienceOn |