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On the Development of Digital Radiography Detectors: A Review  

Kim, Ho-Kyung (School of Mechanical Engineering, Pusan National University)
Cunningham, Ian Alexander (Imaging Research Laboratories, Robarts Research institute)
Yin, Zhye (Computed Tomography System and Application Laboratory, GE Global Research Center)
Cho, Gyu-Seong (Department of Nuclear and Quantum Engineering, Korea Advanced Science and Technology)
Publication Information
International Journal of Precision Engineering and Manufacturing / v.9, no.4, 2008 , pp. 86-100 More about this Journal
Abstract
This article reviews the development of flat-panel detectors for digital radiography based on amorphous materials, Important design parameters and developments are described for the two main components of flat-panel detectors: the X-ray converter and the readout pixel array. This article also introduces the advanced development concepts of new detectors. In addition, the cascaded linear systems method is reviewed because it is a very powerful tool for improving the design and assessment of X-ray imaging detector systems.
Keywords
Digital radiography; Digital X-ray imaging; Flat panel; Scintillator; Photoconductor; Amorphous silicon; Amorphous selenium; Cascaded models;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 6  (Related Records In Web of Science)
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1 Street, R. A., Nelson, S., Antonuk, L. and Perez-Mendez, V., 'Amorphous Silicon Sensor Arrays for Radiation Imaging,' Proc. Mater. Res. Soc., Vol. 192, pp. 441-452, 1990
2 Floyd, Jr., C. E., Warp, R. J., Dobbins, J. T. III, Chotas, H. G., Baydush, A. H., Vargas-Voracek, R. and Ravin, C. E., 'Imaging Characteristics of an Amorphous Silicon Flat-panel Detector for Digital Chest Radiography,' Radiology, Vol. 218, No. 3, pp. 683-688, 2001   DOI
3 Kotter, E. and Langer, M., 'Digital Radiography with Large-area Flat-panel Detectors,' Eur. Radiol., Vol. 12, No. 10, pp. 2562-2570, 2002   DOI
4 Antonuk, L. E., Boudry, J., Huang, W., McShan, D. L., Morton, E. J., Yorkston, J., Longo, M. J. and Street, R. A., 'Demonstration of Megavoltage and Diagnostic X-ray Imaging with Hydrogenated Amorphous Silicon Arrays,' Med. Phys., Vol. 19, No. 6, pp. 1455-1466, 1992   DOI   ScienceOn
5 Kasap, S. O. and Rowlands, J. A., 'Direct-conversion Flat-panel X-ray Image Detectors,' IEE Proc. -Circuits Devices Syst., Vol. 149, No. 2, pp. 85-96, 2002
6 Cunningham, I. A. and Shaw, R., 'Signal-to-noise Optimization of Medical Imaging Systems,' J. Opt. Soc. Am. A, Vol. 16, No. 3, 621-632, 1999   DOI   ScienceOn
7 Bates, C. W., 'Scintillation Process in Thin Films of CsI(Na) and CsI(Tl) due to Low Energy X-rays, Electrons and Photons,' Adv. Electronics Electron Phys., Vol. 28A, pp. 451-459, 1968
8 Knoll, G. F., 'Radiation Detection and Measurement,' John Wiley & Sons, p. 49, 2000
9 Klein, C. A., 'Bandgap Dependence and Related Features of Radiation Ionization Energies in Semiconductors,' J. Appl. Phys., Vol. 39, No. 4, pp. 2029-2038, 1968   DOI
10 Zhao, W., DeCresenzo, G., Kasap, S. O. and Rowlands, J. A., 'Ghosting Caused by Bulk Charge Trapping in Direct Conversion Flat-panel Detectors Using Amorphous Selenium,' Med. Phys., Vol. 32, No. 2, pp. 488-500, 2005   DOI   ScienceOn
11 Kim, H. K., 'Analytical Model for Incomplete Signal Generation in Semiconductor Detectors,' Appl. Phys. Lett., Vol. 88, Issue 13, pp. 132112-1-132112-3, 2006   DOI   ScienceOn
12 Zhao, W., Belvis, I., Germann, S. and Rowlands, J. A., 'Digital Radiology Using Active Matrix Readout of Amorphous Selenium: Construction and Evaluation of a Prototype Real-time Detector,' Med. Phys., Vol. 24, No. 12, pp. 1834-1843, 1997   DOI   ScienceOn
13 Pang, G., Zhao, W. and Rowlands, J. A., 'Digital Radiology Using Active Matrix Readout of Amorphous Selenium: Geometrical and Effective Fill Factors,' Med. Phys., Vol. 25, No. 9, pp. 1636-1646, 1998   DOI   ScienceOn
14 Zhao, W. and Rowlands, J. A., 'Active Matrix X-ray Imaging Array,' United States Patent, No. 5,962,856, 1999
15 Kim, H. J., Kim, H. K., Cho, G. and Choi, J., 'Construction and Characterization of An Amorphous Silicon Flat-panel Detector Based on Ion-shower Doping Process,' Nucl. Instrum. Meth. A, Vol. 505, No. 1-2, pp. 155-158, 2003   DOI
16 Samei, E., Flynn, M. J., Chotas, H. G. and Dobbins, J. T., 'DQE of Direct and Indirect Digital Radiography System,' Proc. SPIE, Vol. 4320, pp. 189-197, 2001
17 Samei, E. and Flynn, M. J., 'An Experimental Comparison of Detector Performance for Direct and Indirect Digital Radiography Systems,' Med. Phys., Vol. 30, No. 4, pp. 608-622, 2003   DOI   ScienceOn
18 Borasi, G., Samei, E., Bertolini, M., Nitrosi, A. and Tassoni, D., 'Contrast-detail Analysis of Three Flat Panel Detectors for Digital Radiography,' Med. Phys., Vol. 33, No. 6, pp. 1707-1719, 2006   DOI   ScienceOn
19 Ducourant, T., Couder, D., Wirth, T., Trochet, J. C., Bastiaens, R. J. M., Bruijins, T. J. C., Luijendijk, H. A., Sandkamp, B., Davies, A. G. and Didier, D., 'Image Quality of Digital Subtraction Angiography Using Flat Detector Technology,' Proc. SPIE, Vol. 5030, pp. 203-214, 2003
20 Moy, J.-P., 'Signal-to-noise Ratio and Spatial Resolution in X-ray Electronic Imagers: Is the MTF a Relevant Parameter?' Med. Phys., Vol. 27, No. 1, pp. 86-93, 2000   DOI   ScienceOn
21 Rocha, J. G. and Correia, J. H., 'A High-performance Scintillator-silicon-well X-ray Microdetector Based on DRIE Techniques,' Sensors and Actuators A, Vol. 92, No. 1-3, pp. 203-207, 2001   DOI
22 Badel, X., Galeckas, A., Linnros, J., Kleimann, P., Frojdh, C. and Petersson, C. S., 'Improvement of an X-ray Imaging Detector Based on a Scintillating Guides Screen,' Nucl. Instrum. Meth. A, Vol. 487, No. 1-2, pp. 129-135, 2002   DOI
23 Zhao, W., Hunt, D. C., Tanioka, K. and Rowlands, J. A., 'Amorphous Selenium Flat Panel Detectors for Medical Applications,' Nucl. Instrum. Meth. A, Vol. 549, No. 1-3, pp. 205-209, 2005   DOI   ScienceOn
24 Simon, M., Engel, K. J., Menser, B., Badel, X. and Linnros, J., 'X-ray Imaging Performance of Scintillator-filled Silicon Pore Arrays,' Med. Phys., Vol. 35, No. 3, pp. 968-981, 2008   DOI   ScienceOn
25 Antonuk, L. E., Li, Y., Du, H., El-Mohri, Y., Zhao, Q., Yamamoto, J., Sawant, A., Wang, Y., Su, Z., Lu, J.-P., Street, R. A., Weisfield, R. and Yao, B., 'Investigation of Strategies to Achieve Optimal DQE Performance from Indirect Detection Active Matrix Flat-panel Imagers (AMFPIs) through Novel Pixel Amplification Architectures,' Proc. SPIE, Vol. 5745, pp. 18-31, 2005
26 Antonuk, L. E., El-Mohri, Y., Zhao, Q., Koniczek, M., McDonald, J., Yeakey, M., Wang, Y., Behravan, M., Street, R. A. and Lu, J.-P., 'Exploration of the Potential Performance of Polycrystalline Silicon-based Active Matrix Flat-panel Imagers Incorporating Active Pixel Sensor Architectures,' Proc. SPIE, Vol. 6913, pp. 69130I-1-69130I-13, 2005
27 Dimitrakopoulos, C. D. and Malenfant, R. L., 'Organic Thin Film Transistors for Large Area Electronics,' Adv. Mater., Vol. 14, No. 2, pp. 99-117, 2002   DOI   ScienceOn
28 Wong, W. S., Ready, S., Matusiak, R., White, S. D., Lu, J.-P., Ho, J. and Street, R. A., 'Amorphous Silicon Thin-film Transistors and Arrays Fabricated by Jet Printing,' Appl. Phys. Lett., Vol. 80, No. 4, pp. 610-612, 2002   DOI   ScienceOn
29 Arias, A. C., Ready, S. E., Lujan, R., Wong, W. S., Paul, K. E., Salleo, A., Chabinyc, M. L., Apte, R., Street, R. A., Wu, Y., Liu, P. and Ong, B., 'All Jet-Printed Polymer Thin-film Transistor Active-matrix Backplanes,' Appl. Phys. Lett., Vol. 85, No. 15, pp. 3304-3306, 2004   DOI   ScienceOn
30 Street, R. A., Wong, W. S., Ready, S., Lujan, R., Arias, A. C., Chabinyc, M. L., Salleo, A., Apte, R. and Antonuk, L. E., 'Printed Active-Matrix TFT Arrays for X-ray Imaging,' Proc. SPIE, Vol. 5745, pp. 7-17, 2005
31 Mettivier, G., Montesi, M. C. and Russo, P., 'First Images of a Digital Autoradiography System Based on a Medipix2 Hybrid Silicon Pixel Detector,' Phys. Med. Biol., Vol. 48, No. 12, pp. N173-N181, 2003   DOI   ScienceOn
32 Thunberg, S., Adelow, L., Blom, O., Coster, A., Egerstrom, J., Eklund, M., Egnell, P., Francke, T., Jordung, U., Kristoffersson, T., Lindman, K., Lindqvist, L., Marchal, D., Olla, H., Penton, E., Peskov, V., Rantanen, J., Sokolov, S., Svedenhag, P., Ullberg, C. and Weber, N., 'Dose Reduction in Mammography with Photon Counting Imaging,' Proc. SPIE, Vol. 5368, pp. 457-465, 2004
33 Davidson, D. W., Watt, J., Tlustos, L., Mikulec, B., Campbell, M., Mathieson, K., O'Shea, V., Smith, K. M. and Rahman, M., 'Detective Quantum Efficiency of the Medipix Pixel Detector,' IEEE Trans. Nucl. Sci., Vol. 50, No. 5, pp. 1659-1663, 2003   DOI   ScienceOn
34 Annovazzi, A., Amendolia, S. R., Bigongiari, A., Bisogni, M. G., Catarsi, F., Cesqui, F., Cetronio, A., Colombo, F., Delogu, P., Fantacci, M. E., Gilberti, A., Lanzieri, C., Lavagna, S., Novelli, M., Passuello, G., Paternoster, G., Pieracci, M., Poletti, M., Quattrocchi, M., Rosso, V., Stefanini, A., Testa, A. and Venturelli, L., 'A GaAs Pixel Detectors-based Digital Mammographic System: Performances and Imaging Tests Results,' Nucl. Instrum. Meth. A, Vol. 576, No. 1, pp. 154-159, 2007   DOI   ScienceOn
35 Thunberg, S., Francke, T., Egerstrom, J., Eklund, M., Ericsson, L., Kristoffersson, T., Peskov, V., Rantanen, J., Sokolov, S., Svedenhag, P., Ullberg, C. K. and Weber, N., 'Evaluation of a Photon Counting Mammography System,' Proc. SPIE, Vol. 4682, pp. 202-208, 2002
36 Maidment, A., Albert, M., Thunberg, S., Adelow, L, Blom, O., Egerstrom, J., Eklund, M., Francke, T., Jordung, U., Kristoffersson, T., Lindman, K., Lindqvist, L, Marchal, D., Olla, H., Penton, E., Rantanen, J., Solokov, S., Ullberg, C. and Weber, N., 'Evaluation of a Photon-counting Breast Tomosynthesis Imaging System,' Proc. SPIE, Vol. 5745, pp. 572-582, 2005
37 Jenkins, G. M. and Watts, D. G., 'Spectral Analysis and Its Application,' Holden-Day Series in Time Series Analysis, Holden-Day, 1968
38 Giger, M. L., Doi, K. and Metz, C. E., 'Investigation of Basic Imaging Properties in Digital Radiography. 2. Noise Wiener Spectrum,' Med. Phys., Vol. 11, No. 6, pp. 797-805, 1984   DOI   ScienceOn
39 Dainty, J. C. and Shaw, R., 'Image Science,' Academic Press, 1974
40 Doi, K., 'Field Characteristics of Geometric Unsharpness Due to the X-ray Tube Focal Spot,' Med. Phys., Vol. 4, No. 1, pp. 15-20, 1977   DOI   ScienceOn
41 Rabbani, M. and van Metter, R. L., 'Analysis of Signal and Noise Propagation for Several Imaging Mechanisms,' J. Opt. Soc. Am. A, Vol. 6, No. 8, pp. 1156-1164, 1989   DOI
42 Cunningham, I. A. and Yao, J., 'Cascaded Models and the DQE of Flat-panel Imagers: Noise Aliasing, Secondary Quantum Noise and Reabsorption,' Proc. SPIE, Vol. 4682, pp. 61-72, 2002
43 Sattarivand, M. and Cunningham, I. A., 'Computational Engine for Development of Complex Cascaded Models of Signal and Noise in X-ray Imaging Systems,' IEEE Trans. Med. Imag., Vol. 24, No. 2, pp. 211-222, 2005   DOI   ScienceOn
44 Zhao, W. and Rowlands, J. A., 'Digital Radiology Using Active Matrix Readout of Amorphous Selenium: Theoretical Analysis of Detective Quantum Efficiency,' Med. Phys., Vol. 24, No. 12, pp. 1819-1833, 1997   DOI   ScienceOn
45 Zhao, W., Ji, W. G. and Rowlands, J. A., 'Effects of Characteristic X rays on the Noise Power Spectra and Detective Quantum Efficiency of Photoconductive X-ray Detectors,' Med. Phys., Vol. 28, No. 10, pp. 2039-2049, 2001   DOI   ScienceOn
46 Kim, H. K., Yun, S. M., Ko, J. S., Cho, G. and Graeve, T., 'Cascade Modeling of Pixelated Scintillator Detectors for X-ray Imaging,' IEEE Trans. Nucl. Sci., Vol. 55, No. 3, pp. 1357-1366, 2008   DOI   ScienceOn
47 Richard, S. and Siewerdsen, J. H., 'Optimization of Dual-energy Imaging Systems Using Generalized NEQ and Imaging Task,' Med. Phys., Vol. 34, No. 1, pp. 127-139, 2007   DOI   ScienceOn
48 Graeve, T., Huang, W., Alexander, S. M. and Li, Y., 'Amorphous Silicon Image Sensor for X-ray Applications,' Proc. SPIE, Vol. 2415, pp. 177-181, 1995
49 Maolinbay, M., Zimmerman, T., Yarema, R. J., Antonuk, L. E., El-Mohri, Y. and Yeakey, M., 'Design and Performance of a Low Noise, 128-channel ASIC Preamplifier for Readout of Active Matrix Flat-panel Imaging Arrays,' Nucl. Instrum. Meth. A, Vol. 485, No. 1, pp. 661-675, 2002   DOI   ScienceOn
50 Borasi, G., Nitrosi, A., Ferrari, P. and Tassoni, D., 'On Site Evaluation of Three Flat Panel Detectors for Digital Radiography,' Med. Phys., Vol. 30, No. 7, pp. 1719-1731, 2003   DOI   ScienceOn
51 Lazzari, B., Belli, G., Gori, G. and Rosselli Del Turco, M., 'Physical Characteristics of Five Clinical Systems for Digital Mammography,' Med. Phys., Vol. 34, No. 7, pp. 2730-2743 2007   DOI   ScienceOn
52 Rowlands, J. A. and Yorkston, J., 'Flat Panel Detectors for Digital Radiography,' Chapter 4, Handbook of Medical Imaging: Vol. 1. Physics and Psychophysics (Eds. Beutel, J., Kundel, H. L. and Van Metter, R.), SPIE, pp. 223-328, 2000
53 Hack, M., Guha, S. and Shur, M., 'Photoconductivity and Recombination in Amorphous Silicon Alloys,' Phys. Rev. B, Vol. 30, No. 12, pp. 6991-6999, 1984   DOI
54 Yarema, R. J., Zimmerman, T., Srage, J., Antonuk, L. E., Berry, J., Huang, W. and Maolinbay, M., 'A Programmable, Low Noise, Multichannel ASIC for Readout of Pixelated Amorphous Silicon Arrays,' Nucl. Instrum. Meth. A, Vol. 439, No. 2-3, pp. 413-417, 2000   DOI
55 Yorker, J. G., Jeromin, L. S., Lee, D. L., Palecki, E. F., Golden, K. P. and Zhenxue, J., 'Characterization of a Full-field Digital Mammography Detector Based on Direct X-ray Conversion in Selenium,' Proc. SPIE, Vol. 4682, pp. 21-29, 2002
56 Sonoda, M., Takano, M., Miyahara, J. and Kato, H., 'Computed Radiography Utilizing Scanning laser Stimulated Luminescence,' Radiology, Vol. 148, No. 3, pp. 833-838, 1983   DOI
57 Gagne, R. M., Quinn, P. W., Chen, L., Myers, K. J. and Doyle, R. J., 'Optically Coupled Digital Radiography: Sources of Inefficiency,' Proc. SPIE, Vol. 4320, pp. 156-162, 2001
58 Granfors, P. R., Albagli, D. Tkaczyk, J. E., Aufrichtig, R., Netel, H., Brunst, G., Boudry, J. and Luo, D., 'Performance of a Flat Panel Cardiac Detector,' Proc. SPIE, Vol. 4320, pp. 77-84, 2001
59 Rivetti, S., Lanconelli, N., Campanini, R., Bertolini, M., Borasi, G., Nitrosi, A., Danielli, C., Angelini, L. and Maggi, S., 'Comparison of Different Commercial FFDM Units by Means of Physical Characterization and Contrast-detail Analysis,' Med. Phys., Vol. 33, No. 11, pp. 4198-4209, 2006   DOI   ScienceOn
60 Karim, K. S., Nathan, A. and Rowlands, J. A., 'Alternative Pixel Architectures for Large Area Medical Imaging,' Proc. SPIE, Vol. 4320, pp. 35-46, 2001
61 Zhao, B. and Zhao, W., 'Temporal Performance of Amorphous Selenium Mammography Detectors,' Med. Phys., Vol. 32, No. 1, pp. 128-136, 2005   DOI   ScienceOn
62 Francke, T., Eklund, M., Ericsson, L, Kristoffersson, T., Peskov, V. N., Rantanen, J., Sokolov, S., Soderman, J. E., Ullberg, C. K. and Weber, N., 'Dose Reduction Using Photon Counting X-ray Imaging,' Proc. SPIE, Vol. 4320, pp. 127-132, 2001
63 Frojdh, C., Graafsma, H., Nilsson, H. E. and Ponchut, C., 'Characterization of a Pixellated CdTe Detector with Single-photon Processing Readout,' Nucl. Instrum. Meth. A, Vol. 563, No. 1, pp. 128-132, 2006   DOI   ScienceOn
64 El-Mohri, Y., Antonuk, L. E., Zhao, Q., Wang, Y., Li, Y., Du, H. and Sawant, A., 'Performance of a High Fill Factor, Indirect Detection Prototype Flat-panel Imager for Mammography,' Med. Phys., Vol. 34, No. 1, pp. 315-327, 2007   DOI   ScienceOn
65 De Geronimo, G., O'Connor, P., Radeka, V. and Yu, B., 'Front-end Electronics for Imaging Detectors,' Nucl. Instrum. Meth. A, Vol. 471, No. 1-2, pp. 192-199, 2001   DOI
66 Holl, I., Lorenz, E. and Mageras, G., 'A Measurement of Light Yield of Some Common Inorganic Scintillators,' IEEE Trans. Nucl. Sci., Vol. 35, No. 1, pp. 105-109, 1988   DOI   ScienceOn
67 Street, R. A., Ready, S. E., Van Schuylenbergh, K., Ho, J., Boyce, J. B. and Nylen, P., 'Comparison of $PbI_2$ and $HgI_2$ for Direct Detection Active Matrix X-ray Image Sensors,' J. Appl. Phys., Vol. 91, No. 5., pp. 3345-3355, 2002   DOI   ScienceOn
68 Wagner, R. F. and Brown, D. G., 'Unified SNR Analysis of Medical Imaging Systems,' Phys. Med. Biol., Vol. 30, No. 6, pp. 489-518, 1985   DOI   ScienceOn
69 ICRU 54, 'Medical Imaging - the Assessment of Image Quality,' International Commission of Radiation Units and Measurements, 1995
70 Rowlands, J. A., 'The Physics of Computed Radiography,' Phys. Med. Biol., Vol. 47, No. 23, pp. R123-R166, 2002   DOI   ScienceOn
71 Weisfield, R. L., Hartney, M., Schneider, R., Aflatooni, K. and Lujan, R., 'High Performance Amorphous Silicon Image Sensor for X-ray Diagnostic Medical Imaging Application,' Proc. SPIE, Vol. 3659, pp. 307-317, 1999
72 Weisfield, R. L., Yao, W., Speaker, T., Zhou, K., Colbeth, R. and Proano, C., 'Performance Analysis of a 127-micron Pixel Large-area TFT/Photodiode Array with Boosted Fill Factor,' Proc. SPIE, Vol. 5368, pp. 338-348, 2004
73 Zhao, W., Hunt, D. C., Tanioka, K. and Rowlands, J. A., 'Indirect Flat-panel Detector with Avalanche Gain,' Proc. SPIE, Vol. 5368, pp. 150-161, 2004
74 Spear W. E. and LeComber P. G., 'Substitutional Doping of Amorphous Silicon,' Solid State Comm., Vol. 17, No. 9, pp. 1193-1196, 1975   DOI   ScienceOn
75 Papoulis, A., 'Probability, Random Variables, and Stochastic Processes,' McGraw-Hill, 1991
76 Schieber, M., Zuch, A., Gilboa, H. and Zentai, G., 'Reviewing Polycrystalline Mercuric Iodide X-ray Detectors,' IEEE Trans. Nucl. Sci., Vol. 53, No. 4, pp. 2385-2391, 2006   DOI   ScienceOn
77 Rabbani, M. Shaw, R. and van Metter, R. L., 'Detective Quantum Efficiency of Imaging Systems with Amplifying and Scattering Mechanisms,' J. Opt. Soc. Am. A, Vol. 4, No. 5, pp. 895-901, 1987   DOI
78 Siewerdsen, J. H., Antonuk, L. E., El-Mohri, Y., Yorkston, J., Huang, W. and Cunningham, I. A., 'Signal, Noise Power Spectrum and Detective Quantum Efficiency of Indirect-detection Flat-panel Imagers for Diagnostic Radiology,' Med. Phys., Vol. 25, No. 5, pp. 614-628, 1998   DOI   ScienceOn
79 Hunt, D. C., Tanioka, K. and Rowlands, J. A., 'X-ray Imaging Using Avalanche Multiplication in Amorphous Selenium: Investigation of Depth Dependent Avalanche Noise,' Med. Phys., Vol. 34, No. 3, pp. 976-986, 2007   DOI   ScienceOn
80 Cho, M. K., Kim, H. K. Graeve, T., Yun, S. M., Lim, C. H., Cho, H. and Kim, J.-M., 'Measurements of X-ray Imaging Performance of Granular Phosphors with Direct-coupled CMOS Sensors,' IEEE Trans. Nucl. Sci., Vol. 55, No. 3, pp. 1338-1343, 2008   DOI   ScienceOn
81 Weckler, G., 'Operation of p-n Junction Photodetectors in a Photon Flux Integrating Mode,' IEEE J. Solid-Sate Circuit, Vol. 2, No. 3, pp. 65-73, 1967   DOI
82 Huang, W., Antonuk, L. E., Berry, J., Maolinbay, M., Martelli, C., Mody, P., Nassif, S. and Yeakey, M., 'An Asynchronous, Pipelined, Electronic Acquisition System for Active Matrix Flat-panel Imagers (AMFPIs),' Nucl. Instrum. Meth. A, Vol. 431, No. 1-2, pp. 273-284, 1999   DOI
83 Mikulec, B., 'Development of Segmented Semiconductor Arrays for Quantum Imaging,' Nucl. Instrum. Meth. A, Vol. 510, No. 1-2, pp. 1-23, 2003   DOI   ScienceOn
84 Richard, S., Siewerdsen, J. H., Jaffray, D. A., Moseley, D. J. and Bakhtiar, B., 'Generalized DQE Analysis of Radiographic and Dual-energy Imaging Using Flat-panel Detectors,' Med. Phys., Vol. 32, No. 5, pp. 1397-1413, 2005   DOI   ScienceOn
85 Kim, H. K., Cho, G., Lee, S. W., Shin, Y. H. and Cho, H. S., 'Development and Evaluation of a Digital Radiographic System Based on CMOS Image Sensor,' IEEE Trans. Nucl. Sci., Vol. 48, No. 3, pp. 662-666, 2001   DOI   ScienceOn
86 Zhao, W., DeCrescenzo, G. and Rowlands, J. A., 'Investigation of Lag and Ghosting in Amorphous Selenium Flat-Panel X-ray Detectors,' Proc. SPIE, Vol. 4682, pp. 9-20, 2002
87 Zhao, W., Waechter, D. and Rowlands, J. A., 'Digital Radiology Using Active Matrix Readout of Amorphous Selenium: Radiation Hardness of Cadmium Selenide Thin Film Transistors,' Med. Phys., Vol. 25, No. 4, pp. 527-538, 1998   DOI   ScienceOn
88 Kameshima, T., Kaifu, N., Takami, E., Morishita, M. and Yamazaki, T., 'Novel Large Area MIS-type X-ray Image Sensor for Digital Radiography,' Proc. SPIE, Vol. 3336, pp. 453-462, 1998
89 Zhao, W., Li, D., Reznik, A., Lui, B., Hunt, D. C., Tanioka, K. and Rowlands, J. A., 'Indirect Flat-panel Detector with Avalanche Gain: Fundamental Feasibility Investigation for SHARP-AMFPI (Scintillator HARP Active Matrix Flat Panel Imager),' Med. Phys. Vol. 32, No. 9, pp. 2954-2966, 2005   DOI   ScienceOn
90 Swank, R. K., 'Absorption and Noise in X-ray Phosphors,' J. Appl. Phys., Vol. 44, No. 9, pp. 4199-4203, 1973   DOI   ScienceOn
91 Akbarpour, R., Friedman, S. N., Siewerdsen, J. H., Neary, J. D. and Cunningham, I. A., 'Signal and Noise Transfer in Spatiotemporal Quantum-based Imaging Systems,' J. Opt. Soc. Am. A, Vol. 24, No. 12, pp. B151-B164, 2007   DOI
92 Granfors, P. R. and Aufrichtig, R., 'Performance of a $41{\times}41-cm^2$ Amorphous Silicon Flat Panel X-ray Detector for Radiographic Imaging Applications,' Med. Phys., Vol. 27, No. 6, pp. 1324-1331, 2000   DOI   ScienceOn
93 Zhao, W. and Rowlands, J. A., 'X-ray Imaging Using Amorphous Selenium: Feasibility of a Flat Panel Self-scanned Detector for Digital Radiology,' Med. Phys., Vol. 22, No. 10, pp. 1595-1604, 1995   DOI   ScienceOn
94 Rau, A. W., Bakueva, L. and Rowlands, J. A., 'The X-ray Time of Flight Method for Investigation of Ghosting in Amorphous Selenium-based Flat Panel Medical X-ray Imagers,' Med. Phys., Vol. 32, No. 10, pp. 3160-3177, 2005   DOI   ScienceOn
95 Bloomquist, A. K., Yaffe, M. J., Mawdsley, G. E., Hunter, D. M. and Beideck, D. J., 'Lag and Ghosting in a Clinical Flat-panel Selenium Digital Mammography System,' Med. Phys., Vol. 33, No. 8, pp. 2998-3005, 2006   DOI   ScienceOn
96 Shaw, J., Albagli, D., Wei, C. Y. and Granfors, P. R., 'Enhanced a-Si/CsI-based Flat panel X-ray Detector for Mammography,' Proc. SPIE, Vol. 5368, pp. 370-378, 2004
97 Tao, S., Gu, Z. H. and Nathan, A., 'Fabrication of Gd2O2S:Tb Based Phosphor Films Coupled with Photodetectors for X-ray Imaging Applications,' J. Vac. Sci. Technol. A, Vol. 20, No. 3, pp. 1091-1094, 2002   DOI   ScienceOn
98 Sauli, F., 'GEM: a New Concept for Electron Amplification in Gas Detectors,' Nucl. Instrum. Meth. A, Vol. 386, No. 2-3, pp. 531-534, 1997   DOI   ScienceOn
99 Rossmann, K., 'The Spatial Frequency Spectrum: a Means for Studying the Quality of Radiographic Imaging Systems,' Radiology, Vol. 90, No. 1, pp. 1-13, 1968   DOI
100 Munro, P. and Bouius, D. C., 'X-ray Quantum Limited Portal Imaging Using Amorphous Silicon Flat-panel Arrays,' Med. Phys., Vol. 25, No. 5, pp. 689-702, 1998   DOI   ScienceOn
101 Rocha, J. G., Ramos, N. F., Lanceros-Mendez, S., Wolffenbuttel, R.. F. and Correia, J. H., 'CMOS X-rays Detector Array Based on Scintillating Light Guides,' Sensors and Actuators A, Vol. 110, No. 1-3, pp. 119-123, 2004   DOI
102 Cha, B. K., Bae, J. H., Kim, B.-J., Jeon, H. and Cho, G., 'Performance Studies of a Monolithic Scintillator-CMOS Image Sensor for X-ray Application,' Nucl. Instrum. Meth. A, Vol. 591, No. 1, pp. 113-116, 2008   DOI   ScienceOn
103 Kasap, S. O. and Rowlands, J. A., 'Photoconductor Selection for Digital Flat Panel X-ray Image Detectors Based on the Dark Current,' J. Vac. Sci. Technol. A, Vol. 18, No. 2, pp. 615-620, 2000   DOI   ScienceOn
104 Hajdok, G., Yao, J., Battista, J. J. and Cunningham, I. A., 'Signal and Noise Transfer Properties of Photoelectric Interactions in Diagnostic X-ray Imaging Detectors,' Med. Phys., Vol. 33, No. 10, pp. 3601-3620, 2006   DOI   ScienceOn
105 Kim, H. K., 'Generalized Cascaded Model to Assess Noise Transfer in Scintillator-based X-ray Imaging Detectors,' Appl. Phys. Lett., Vol. 89, Issue 23, pp. 233504-1-233504-3, 2006   DOI   ScienceOn
106 Chotas, H. G., Dobbins, J. T. III and Ravin, C. E., 'Principles of Digital Radiography with Large-Area, Electronically Readable Detectors: a Review of the Basics,' Radiology, Vol. 210, No. 3, pp. 595-599, 1999   DOI
107 Kasap, S. O., Zahangir Kabir, M. and Rowlands, J. A., 'Recent Advances in X-ray Photoconductors for Direct Conversion X-ray Image Detectors,' Cur. Appl. Phys., Vol. 6, No. 3, pp. 288-292, 2006   DOI   ScienceOn
108 Zhao, W., Li, D., Rowlands, J. A., Egami, N., Takiguchi, Y., Nanba, M., Honda, Y., Ohkawa, Y., Kubota, M., Tanioka, K., Suzuki, K. and Kawai, T., 'An Indirect Flat-panel Detector with Avalanche Gain for Low Dose X-ray Imaging: SAPHIRE (Scintillator Avalanche Photoconductor with High Resolution Emitter Readout),' Proc. SPIE, Vol. 6913, pp. 69130M-1-69130M-11, 2008
109 Ito, H., Matsubara, S., Takahashi, T., Shimada, T. and Takeuchi, H., 'Integrated Radiation Detectors with a-Si Photodiodes on Ceramic Scintillators,' Jpn. J. Appl. Phys., Vol. 28, No. 8, pp. L1476-L1479, 1989   DOI
110 Nikl, M., 'Scintillation Detectors for X-rays,' Meas. Sci. Technol., Vol. 17, No. 4, pp. R37-R54, 2006   DOI
111 Haugen, C., Kasap, S. O. and Rowlands, J. A., 'X-ray Irradiation Induced Bulk Space Charge in Stabilized a-Se X-ray Photoconductors,' J. Appl. Phys., Vol. 84, No. 10, pp. 5495-5501, 1998   DOI
112 Monnin, P., Gutierrez, D., Bulling, S., Guntern, D. and Verdun, F. R., 'A Comparison of the Performance of Digital Mammography Systems,' Med. Phys., Vol. 34, No. 3, pp. 906-914, 2007   DOI   ScienceOn
113 El-Mohri, Y., Antonuk, L. E., Zhao, Q., Maolinbay, M., Rong, X., Jee, K.-W., Nassif, S. and Cionca, C., 'A Quantitative Investigation of Additive Noise Reduction for Active Matrix Flat-panel Imagers Using Compensation Lines,' Med. Phys., Vol. 27, No. 8, pp. 1855-1864, 2000   DOI   ScienceOn
114 Beuville, E., Belding, M., Costello, A., Hansen, R. and Petronio, S., 'High Performance, Low-noise, 128-channel Readout Integrated Circuit for Flat Panel X-ray Detector Systems,' Proc. SPIE, Vol. 5368, pp. 714-725, 2004
115 Gobbi, D. G., Dixit, M. S., Dubeau, J. and Johns, P. C., 'Photon-counting Radiography with the Gas Microstrip Detector,' Phys. Med. Biol., Vol., 44, No. 5, pp. 1317-1335, 1999   DOI   ScienceOn
116 Antonuk, L. E., El-Mohri, Y., Jee, K.-W., Zhao, Q., Sawant, A., Su, Z. and Street, R. A., 'Technological Pathways for 21st Century Active Matrix X-ray Imager Development,' Proc. SPIE, Vol. 4682, pp. 1-8, 2002
117 Siewerdsen, J. H. and Jaffray, D. A., 'A Ghost Story: Spatio-temporal Response Characteristics of an Indirect-detection Flat-panel Imager,' Med. Phys., Vol. 26, No. 8, pp. 1624-1641, 1999
118 Street, R. A., 'Hydrogenated Amorphous Silicon,' Cambridge University Press, 1991
119 Vedantham, S., Karellas, A., Suryanarayanan, S., Albagli, D., Han, S., Tkaczyk, E. J., Landberg, C. E., Opsahl-Ong, B., Granfors, P. R., Levis, I., D'Orsi, C. J. and Hendrick, R. E., 'Full Breast Digital Mammography with an Amorphous Silicon-based Flat Panel Detector: Physical Characteristics of a Clinical Prototype,' Med. Phys., Vol. 27, No. 3, pp. 558-567, 2000   DOI   ScienceOn
120 Cheung, L. K., Jing, Z., Bogdanovich, S., Golden, K., Robinson, S., Beliaevskaia, E. and Parikh, S., 'Image Performance of a New Amorphous Selenium Flat Panel X-ray Detector Designed for Digital Breast Tomosynthesis,' Proc. SPIE, Vol. 5745, pp. 1282-1290, 2005
121 Bertolucci, E., Maiorino, M., Mettivier, G., Montesi, M. C. and Russo, P., 'Preliminary Test of an Imaging Probe for Nuclear Medicine Using Hybrid Pixel Detectors,' Nucl. Instrum. Meth. A, Vol. 487, No. 1-2, pp. 193-201, 2002   DOI
122 Barrett, H. H. and Swindell, W., 'Radiological Imaging - the Theory of Image Foundation, Detection, and Processing,' Academic Press, 1981
123 Llopart, X., Campbell, M., Dinapoli, R., San Segundo, D. and Pernigotti, E., 'Medipix2: a 64-k Pixel Readout Chip with $55 {\mu}m$ Square Elements Working in Single Photon Counting Mode,' IEEE Trans. Nucl. Sci., Vol. 49, No. 5, pp. 2279-2283, 2002   DOI   ScienceOn
124 Avila, C., Lopez, J., Sanabria, J. C., Baldazzi, G., Bollini, D., Gombia, M., Cabal, A. E., Ceballos, C., Diz Garcia, A., Gambaccini, M., Taibi, A., Sarnelli, A., Tuffanelli, A., Giubellino, P., Marzari-Chiesa, A., Prino, F., Tomassi, E., Grybos, P., Idzik, M., Swientek, K., Wiacek, P., Montano, L. M., Ramello, L. and Sitta, M., 'Contrast Cancellation Technique Applied to Digital X-ray Imaging Using Silicon Strip Detectors,' Med. Phys., Vol. 32, No. 12, pp. 3755-3766, 2005   DOI   ScienceOn
125 Metz, C. E. and Doi, K., 'Transfer Function Analysis of Radiographic Imaging Systems,' Phys. Med. Biol., Vol. 24, No. 6, pp. 1079-1106, 1979   DOI   ScienceOn
126 Daniel, J. H., Krusor, B., Apte, R. B., Mulato, M., Van Schuylenbergh, K., Lau, R., Do, T., Street, R. A., Goredema, A. and Boils-Boissier, D. C., 'Micro-electro-mechanical System Fabrication Technology Applied to Large Area X-ray Image Sensor Arrays,' J. Vac. Sci. Technol. A, Vol. 19, No. 4, pp. 1219-1223, 2001   DOI   ScienceOn
127 Du, H., Antonuk, L. E., El-Mohri, Y., Zhao, Q., Su, Z., Yamamoto, J. and Wang, Y., 'Investigation of the Signal Behavior at Diagnostic Energies of Prototype, Direct Detection, Active Matrix, Flat-panel Imagers Incorporating Polycrystalline $HgI_2$,' Phys. Med. Biol., Vol. 53, No. 5, pp. 1325-1351, 2008   DOI   ScienceOn
128 Shikhaliev, P. M., Xu, T. and Molloi, S., 'Photon Counting Computed Tomography: Concept and Initial Results,' Med. Phys., Vol. 32, No. 2, pp. 427-436, 2005   DOI   ScienceOn
129 Rossmann, K., 'Measurement of the Modulation Transfer Function of Radiographic Systems Containing Fluorescent Screens,' Phys. Med. Biol., Vol. 9, No. 4, pp. 551-557, 1964   DOI   ScienceOn
130 Que, W. and Rowlands, J. A., 'X-ray Photogeneration in Amorphous Selenium: Geminate versus Columnar Recombination,' Phys. Rev. B, Vol. 51, No. 16, pp. 10500-10507, 1995   DOI
131 Matsuura, N., Zhao, W., Huang, Z. and Rowlands, J. A., 'Digital Radiology Using Active Matrix Readout: Amplified Pixel Detector Array for Fluoroscopy,' Med. Phys., Vol. 26, No. 5, pp. 672-681, 1999   DOI   ScienceOn
132 Kim, H. K., Ahn, J. K. and Cho, G., 'Development of a Lens-coupled CMOS Detector for X-ray Inspection System,' Nucl. Instrum. Meth. A, Vol. 545, No. 1-2, pp. 210-216, 2005   DOI
133 Giomataris, Y., Rebourgeard, Ph., Robert, J. P. and Charpak, G., 'MICROMEGAS: a High-granularity Position-sensitive Gaseous Detectors for High Particle-flux Environments,' Nucl. Instrum. Meth. A, Vol. 376, No. 1, pp. 29-35, 1996   DOI   ScienceOn
134 Cunningham, I. A., 'Applied Linear-systems Theory,' Chapter 2, Handbook of Medical Imaging: Vol. 1. Physics and Psychophysics (Eds. Beutel, J., Kundel, H. L. and Van Metter, R.), SPIE, pp. 79-159, 2000
135 Gaskill, J. D., 'Linear Systems, Fourier Transforms, and Optics,' John Wiley & Sons, 1978
136 Yaffe, M. J. and Rowlands, J. A., 'X-ray Detectors for Digital Radiography,' Phys. Med. Biol. Vol. 42, No. 1, pp. 1-39, 1997   DOI   ScienceOn
137 Rowlands, J. and Kasap, S., 'Amorphous Semiconductors Usher in Digital X-ray Imaging,' Phys. Today, Vol. 50, No. 11, pp. 24-30, 1997
138 Ducourant, T., Michel, M. Vieux, G., Peppler, T., Trochet, J. C., Schulz, R. F., Bastiaens, R. J. M. and Busse, F., 'Optimization of Key Building Blocks for a Large-area Radiographic and Fluoroscopic Dynamic Digital X-ray Detector Based on a-Si:H/CsI:Tl Flat Panel Technology,' Proc. SPIE, Vol. 3977, pp. 14-25, 2000
139 Yorkston, J., 'Recent Developments in Digital Radiography Detectors,' Nucl. Instrum. Meth. A, Vol. 580, No. 2, pp. 974-985, 2007   DOI   ScienceOn
140 Street, R. A., 'Large Area Image Sensor Arrays,' Chapter 4, Technology and Applications of Amorphous Silicon (Ed. R. A. Street), Springer-Verlag, pp. 147-221, 2000
141 Siewerdsen, J. H., Antonuk, L. E., El-Mohri, Y., Yorkston, J., Huang, W., Boudry, J. M. and Cunningham, I. A., 'Empirical and Theoretical Investigation of the Noise Performance of Indirect Detection, Active Matrix Flat-panel Imagers (AMFPIs) for Diagnostic Radiology,' Med. Phys., Vol. 24, No. 1, pp. 71-89, 1997   DOI   ScienceOn
142 Ng, T. N., Lujan, R. A., Sambandan, S., Street, R. A., Limb, S. and Wong, W. S., 'Low Temperature a-Si:H Photodiodes and Flexible Image Sensor Arrays Patterned by Digital Lithography,' Appl. Phys. Lett., Vol. 91, No. 6, pp. 063505-1-063505-3, 2007   DOI   ScienceOn
143 Rossmann, K., 'Point Spread-function, Line Spread-function, and Modulation Transfer Function. Tools for the Study of Imaging Systems,' Radiology, Vol. 93, No. 2, pp. 257-272, 1969   DOI
144 Shaw, R., 'The Equivalent Quantum Efficiency of the Photographic Process,' J. Photogr. Sc., Vol. 11, pp. 199-204, 1963   DOI
145 Metz, C. E., Wagner, R. F., Doi, K., Brown, D. G., Nishikawa, R. M. and Myers, K. J., 'Toward Consensus on Quantitative Assessment of Medical Imaging Systems,' Med. Phys., Vol. 22, No. 7, pp. 1057-1061, 1995   DOI   ScienceOn
146 Papoulis, A., 'Systems and Transforms with Applications in Optics,' McGraw-Hill, 1968
147 Weil, E., 'Some Bibliographical Notes on the First Publication on the Roentgen Rays,' Isis, Vol. 29, No. 2, pp. 362-365, 1938   DOI   ScienceOn
148 Moy, J.-P., 'Recent Developments in X-ray Imaging Detectors,' Nucl. Instrum. Meth. A, Vol. 442, No. 1-3, pp. 26-37, 2000   DOI
149 Stevels, A. L. N. and Schrama de Pauw, A. D. M., 'Vapor-deposited CsI:Na Layers, I. Morphologic and Crystallographic Properties, II. Screen for Application in X-ray Imaging Devices,' Philips Res. Rept., Vol. 29, pp. 340-362, 1974
150 Street, R. A., Ready, S. E, Melekhov, L., Ho, J., Zuck, A. and Breen, B., 'Approaching the Theoretical X-ray Sensitivity with HgI2 Direct Detection Image Sensors,' Proc. SPIE, Vol. 4682, pp. 414-422, 2002
151 Antonuk, L. E., Jee, K.-W., El-Mohri, Y., Maolinbay, M., Nassif, S., Rong, X., Zhao, Q., Siewerdsen, J. H., Street, R. A. and Shah, K. S., 'Strategies to Improve the Signal and Noise Performance of Active Matrix, Flat-panel Imagers for Diagnostic X-ray Applications,' Med. Phys., Vol. 27, No. 2, pp. 289-306, 2000   DOI   ScienceOn
152 Rahn, J. T., Lemmi, F., Weisfield, R. L., Lujan, R., Mei, P. Lu, J.-P., Ho, J., Ready, S. E., Apte, R. B., Nylen, P., Boyce, J. B. and Street, R. A., 'High Resolution, High Fill Factor a-Si:H Sensor Arrays for Medical Imaging,' Proc. SPIE, Vol. 3659, pp. 510-517, 1999
153 Lu, J. P., Van Schuylenbergh, K., Ho, J., Wang, Y., Boyce, J. B. and Street, R. A., 'Flat Panel Imagers with Pixel Level Amplifiers Based on Polycrystalline Silicon Thin-film Transistor Technology,' Appl. Phys. Lett., Vol. 80, No. 24, pp. 4656-4658, 2002   DOI   ScienceOn
154 Yao, J. and Cunningham, I. A., 'Parallel Cascades: New Ways to Describe Noise Transfer in Medical Imaging Systems,' Med. Phys., Vol. 28, No. 10, pp. 2020-2038, 2001   DOI   ScienceOn
155 James, J. J., Davies, A. G., Cowen, A. R. and O'Connor, P. J., 'Developments in Digital Radiography: An Equipment Update,' Eur. Radiol., Vol. 11, No. 12, pp. 2616-2626, 2001   DOI   ScienceOn
156 Spahn, M., 'Flat Detectors and Their Clinical Applications,' Eur. Radiol., Vol. 15, No. 9, pp. 1934-1947, 2005   DOI   ScienceOn
157 Cunningham, I. A., Westmore, M. S. and Fenster, A., 'A Spatial-frequency Dependent Quantum Accounting Diagram and Detective Quantum Efficiency Model of Signal and Noise Propagation in Cascaded Imaging Systems,' Med. Phys., Vol. 21, No. 3, pp. 417-427, 1994   DOI   ScienceOn
158 Guha, S. and Hack, M., 'Dominant Recombination Process in Amorphous Silicon Alloys,' J. Appl. Phys., Vol. 58, No. 4, pp. 1683-1685, 1985   DOI
159 Li, D. and Zhao, W., 'SAPHIRE (Scintillator Avalanche Photoconductor with High Resolution Emitter Readout) for Low Dose X-ray Imaging: Spatial Resolution,' Med. Phys. Vol. 35, No. 7, pp. 3151-3161, 2008   DOI   ScienceOn
160 Barrett, H. H. and Meyers, K. J., 'Foundations of Image Science,' Wiley, 2004
161 Zhao, W., Law, J., Waechter, D., Huang, Z. and Rowlands, J. A., 'Digital Radiology Using Active Matrix Readout of Amorphous Selenium: Detectors with High Voltage Protection,' Med. Phys., Vol. 25, No. 4, pp. 539-549, 1998   DOI   ScienceOn
162 Lee, D. L., Cheung, L. K. and Jeromin, L. S., 'A New Digital Detector for Projection Radiography,' Proc. SPIE, Vol. 2432, pp. 237-249, 1995
163 van Eijk, C. W. E., 'Inorganic Scintillators in Medical Imaging,' Phys. Med. Biol., Vol. 47, No. 8, pp. R85-R106, 2002   DOI   ScienceOn
164 Abkowitz, M., 'Density of States in a-Se from Combined Analysis of Xerographic Potentials and Transient Transport Data,' Phil. Mag. Lett., Vol. 58, No. 1, pp. 53-57, 1988   DOI   ScienceOn
165 Kleimann, P., Linnros, J., Frojdh, C. and Petersson, C. S., 'An X-ray Imaging Pixel Detector Based on Scintillator Filled Pores in a Silicon Matrix,' Nucl. Instrum. Meth. A, Vol. 460, No. 1, pp. 15-19, 2001   DOI   ScienceOn
166 Mettivier, G., Montesi, M. C. and Russo, P., 'Digital Autoradiography with a Medipix2 Hybrid Silicon Pixel Detector,' IEEE Trans. Nucl. Sci., Vol. 52, No. 1, pp. 46-50, 2005   DOI   ScienceOn
167 Paul, K. E., Wong, W. S., Ready, S. E. and Street, R. A., 'Additive Jet Printing of Polymer Thin-film Transistors,' Appl. Phys. Lett., Vol. 83, No. 10, pp. 2070-2072, 2003   DOI   ScienceOn