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Analysis of Substitution Events in HIV-1 vif Gene of the Korean Clade  

Park, Chan-Seung (School of Life Sciences, Chungbuk National University)
Kim, Mi-Sook (School of Life Sciences, Chungbuk National University)
Yi, Hyun-Ah (School of Life Sciences, Chungbuk National University)
Lee, Dong-Hun (School of Life Sciences, Chungbuk National University)
Lee, Keon-Myung (School of Electrical and Computer Engineering, Chungbuk National University)
Lee, Chan-Hee (School of Life Sciences, Chungbuk National University)
Publication Information
Journal of Microbiology / v.45, no.1, 2007 , pp. 75-78 More about this Journal
Abstract
Nucleotide and amino acid substitution pattern in vif gene of the Korean clade of HIV-1 isolated from Koreans were analyzed using consensus sequences. At nucleotide level, transition/transversion substitution ratio was 1.88, and nonsynonymous/synonymous substitution ratio was 2.67, suggesting a divergent evolution in the Korean clade. At amino acid level, there were 17 substitutions and $G{\rightarrow}E$ substitution at position 37 may be responsible for change in predicted secondary structure.
Keywords
HIV-1; vif; Korean clade; substitution ratio;
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