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http://dx.doi.org/10.20307/nps.2022.28.2.62

Chemical Profile and Cytotoxicity Activity of Stem-bark of Anacardium occidentale  

Shehu, Abdullahi (Department of Chemistry, Faculty of Science, Federal University Lokoja)
Ponnapalli, Mangala Gowri (Centre for Natural Products and Traditional Knowledge, Indian Institute of Chemical Technology)
Mahboob, Mohd (Toxicology Unit, Biology Division, Indian Institute of Chemical Technology)
Prabhakar, Pitta Venkata (Toxicology Unit, Biology Division, Indian Institute of Chemical Technology)
Olatunji, Gabriel Ademola (Department of Industrial Chemistry, Faculty of Physical Sciences, University of Ilorin)
Publication Information
Natural Product Sciences / v.28, no.2, 2022 , pp. 62-67 More about this Journal
Abstract
Column chromatographic fractionation of the methanol and ethyl acetate extracts of the stem-bark of Anacardium occidentale led to the isolation of five compounds (1-5). Their structures were determined by spectroscopic means by comparing spectral data to be β-sitosterol (1), 2,4-dihydroxy acetophenone (2), 1-monolinolein (3), ethyl oleate (4) and β-sitosterol-3-O-β-D-glucopyranoside (5). These compounds were evaluated for cytotoxicity against human cancer cell lines: A549, SCOV3 and rat normal cell line NRK49f. Compounds 2-5 were for the first time isolated from A. occidentale.
Keywords
Anacardium occidentale; Anacardiaceae; ${\beta}$-sitosterol; MTT assay; cytotoxicity;
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