[KSCI] Korea Science Citation Index Service

Chemical Constituents from Leaves of Acanthopanax henryi (II)

Li, Zhi (School of Pharmacy, Hunan University of Chinese Medicine)
Li, Xiao Jun (School of Pharmacy, Hunan University of Chinese Medicine)
Kwon, Ok Kyoung (Korea Research Institute of Bioscience and Biotechnology)
Wang, Xiang (School of Pharmacy, Hunan University of Chinese Medicine)
Zou, Qin Peng (Broad-Ocean Bio-Science and Technique Co., Ltd of)
Liu, Xiang Qian (School of Pharmacy, Hunan University of Chinese Medicine)
Lee, Hyeong kyu (Korea Research Institute of Bioscience and Biotechnology)

Publication Information

Natural Product Sciences / v.21, no.3, 2015 , pp. 196-204 More about this Journal

Abstract

Nineteen compounds, including one organic acid (1), one anthraquinone (2), one amide (3), and sixteen triterpenoid saponins (4 - 19) were isolated from the leaves of Acanthopanax henryi (Oliv.) Harms (Araliaceae). Their structures were determined on the basis of physicochemical properties and spectral analyses (HR-MS and NMR). Among them, compounds 2, 3, 7, 12 and 19 were new within Araliaceae. Compounds 4, 5, 9 - 11, 13, 14, 16 and 18 were reported for the first time from the Acanthopanax genus. Except for compounds 4 and 9, other compounds were isolated from A. henryi (Oliv.) Harms for the first time. The rare anthraquinone, compound 2, significantly decreased the production of NO and the levels of other inflammatory factors, such as TNF-α and IL-6, in lipopolysaccharide (LPS)-stimulated macrophages in a dose-dependent manner. This is the first time to report anti-inflammatory effect of this compound.

Keywords

Araliaceae; Acanthopanax henryi; Triterpenoid saponins; Anthraquinone; Nitric oxide; Anti-inflammatory;

Citations & Related Records

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