Browse > Article

Phytochemical Constituents of Thesium chinense TURCZ and Their Cytotoxic Activities In Vitro  

Lee, Il-Kyun (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Kim, Ki-Hyun (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Choi, Sang-Un (Research Institute of Chemical Technology)
Lee, Jae-Hyun (College of Oriental Medicine, Dongguk University)
Lee, Kang-Ro (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Publication Information
Natural Product Sciences / v.15, no.4, 2009 , pp. 246-249 More about this Journal
Abstract
Column chromatographic separation of the MeOH extract from the aerial parts of Thesium chinense TURCZ led to the isolation of two norsesquiterpenes (1 - 2), two phenylpropanes (3 - 4) and four flavonoids (5 - 8). Their structures were determined by spectroscopic means to be 5,6-epoxy-3-hydroxy-7-megastigmen-9-ene (1), (-)-loliolide (2), methyl-p-hydroxycinnamate (3), methyl caffeate (4), kaempferol (5), kaempferol-3-O-${\beta}$-Dglucopyranoside (6), kaepmferol-3,7-di-O-${\beta}$-D-glucopyranoside (7) and kaempferol-3-O-${\beta}$-D-glucopyranoside-6''-(3-hydroxy-3-methylglutarate) (8). Compounds 1 - 4, 7 and 8 were first isolated from this source. The isolated compounds were evaluated for their cytotoxicty in vitro using the sulforhodamin B bioassay (SRB).
Keywords
Thesium chinense; Norsesquiterpene; Phenylpropane; Flavonoid; Cytotoxicity;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By SCOPUS : 1
연도 인용수 순위
1 Berhow, M.A., Bennett, R.D., Poling, S.M., Vannier, S., Hidaka, T., and Omura, M., Acylated flavonoids in dallus cultures of Citrus aurantifolia. Phytochemistry, 36, 1225-1227, (1994)   DOI   ScienceOn
2 Jung, K.Y., Do, J.C., and Son, K.H., Kaempferol-3-O-[6$^{\prime}$$^{\prime}$-O-(3-hydroxy-3-methylglutaroyl)-glucoside] from leaves of Polygala japonica. Phytochemistry, 34, 1196-1197, (1993)   DOI   ScienceOn
3 Lu, Y. and Wang, J., Study on chemical constituents of Thesium chinensis. Zhongcaoyao, 35, 491-493 (2004)
4 Do, J.C., Uu, Y.J., Jung, K.Y., and Son, K.H., Flavonoids from the leaves of Polygala japonica. J. Kor. Chem. Soc., 23, 9-13, (1992)
5 Kim, K.H, Lee, K.H., Choi, S.U., Kim, Y.H., and Lee, K.R., Terpene and phenolic constituents of Lactuca indica L. Arch. Pharm. Res., 31, 983-988, (2008)   DOI   ScienceOn
6 Choi, S.Z., Choi, S.U., and Lee, K.R., Phytochemical constituents of the aerial parts from Solidago virga-aurea var. gigintea. Arch. Pharm. Res., 27, 164-168, (2004)   DOI   ScienceOn
7 Park, K.E., Kim, Y.A., Jung, H.A., Lee, H.J., Ahn, J.W., Lee, B.J., and Seo, Y.W., Three norisoprenoids from the brown alga Sargassum thunvergii. J. Kor. Chem. Soc., 48, 394-398, (2004)   DOI   ScienceOn
8 Skehan, P., Stroreng, R., Scudiero, D., Monks, A., Mcmahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenney, S., and Boyd, M.R., New colorimetric cytotoxicity assay for anticacer-drug screening. J. Natl. Cancer Inst., 82, 1107-1112 (1990)   DOI   PUBMED
9 Ahn, D.K., Illustrated Book of Korean Medicinal Herbs, Kyo-hak Publishing Co., p.165 (1998)
10 Wang, Z. and Li, S.S., Isolation and identification of alkaloid from Thesium chinense Turcz. Chinese J. Med.Chem., 16, 306-308, (2006)
11 Lee, J.H., Ku, C.H., Baek, N.I., Kim, S.H., Park, H.W., and Kim, D.K., Phytochemical constituents from Diodia teres. Arch. Pharm. Res., 27, 40-43, (2004)   DOI   ScienceOn