Browse > Article

Minor Phenolic Constituents of the Anemarrhenae Rhizoma  

Youn, Ui-Joung (Natural Product Chemistry Laboratory, College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans University)
Lee, Ye-Seul (Natural Product Chemistry Laboratory, College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans University)
Jeong, Ha-Na (Natural Product Chemistry Laboratory, College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans University)
Nam, Joo-Won (Natural Product Chemistry Laboratory, College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans University)
Lee, Yoo-Jin (Natural Product Chemistry Laboratory, College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans University)
Son, Young-Min (Natural Product Chemistry Laboratory, College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans University)
Hwang, Eun-Sook (Natural Product Chemistry Laboratory, College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans University)
Seo, Eun-Kyoung (Natural Product Chemistry Laboratory, College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans University)
Publication Information
Natural Product Sciences / v.15, no.4, 2009 , pp. 203-207 More about this Journal
Abstract
A homoisoflavanone, 7,4'-dihydroxyhomoisoflavanone (1) and a flavanone, (2S)-7,4'-dihydroxy-5-methoxyflavanone (2), were isolated from the rhizomes of Anemarrhena asphodeloides, together with 4,4'-dihydroxychalcon (3), 2'-O-methylphlorethin (4), 1,3-bis-di-p-hydroxyphenyl-4-penten-1-one (5), and 2,4'-dihydroxy-4-methoxybenzophenone (6) on the basis of spectroscopic and physicochemical analyses including 1Dand 2D- NMR techniques as well as by comparison of their data with the published values. Compounds 1 - 4 were isolated for the first time from this plant source. Among isolates, compound 2 exhibited moderate inhibitory effect on the differentiation of pre-adipocyte 3T3-L1 cells.
Keywords
Anemarrhena asphodeloides; Liliaceae; Homoisoflavanone; Antiadipogenic activity;
Citations & Related Records

Times Cited By SCOPUS : 0
연도 인용수 순위
  • Reference
1 Iida, Y., Oh, K.B., Saito, M., Matsuoka, H., and Kurata, H., In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans. Planta Med. 66, 435-438 (2000)   DOI   ScienceOn
2 Pardo-Andreu, G.L., S$\acute{a}$nchez-Baldoqu$\acute{i}$n, C., $\acute{A}$vila-Gonz$\acute{a}$lez, Ren$\grave{e}$ ., Delgado, R., Naal, Z., and Curti, C., Fe(III) improves antioxidant and cytoprotecting activities of mangiferin. Eur. J. Pharmacol. 547, 31-36 (2006)   DOI   PUBMED   ScienceOn
3 Park, H.J., Lee, J.Y., Moon, S.S., and Hwang, B.K., Isolation and antioomycete activity of nyasol from Anemarrhena asphodeloides rhizomes. Phytochemistry 64, 997-1001 (2003)   DOI   ScienceOn
4 Sy, L.K., Yan, S.C., Lok, C.N., Man, R.Y.K., and Che, C.M., Timosaponin A-III induces autophagy preceding mitochondriamediated apoptosis in HeLa cancer cells. Cancer Res. 68, 10229-10237 (2008)   DOI   ScienceOn
5 Triana, J., Lopez, M., Perez, F.J., Platas, Javier Gonz$\acute{a}$lez., Estevez, F., Le$\acute{o}$n, J,F., Hern$\acute{a}$ndez, J.C., Brouard, I., and Bermejo, J., Chemical constituents of Tolpis species. Fitoterapia 80, 437-441 (2009)   DOI   ScienceOn
6 Nakashima, N., Kimura, I., and Kimura, M., Isolation of pseudoprototimosaponin AIII from rhizomes of Anemarrhena asphodeloides and its hypoglycemic activity in streptozotocin-induced diabetic mice. J. Nat. Prod. 56, 345-350 (1993)   DOI   ScienceOn
7 Ren, L.X., Luo, Y.F., Li, X., Zuo, D.Y., and Wu, Y.L., Antidepressant-like effects of sarsasapogenin from Anemarrhena asphodeloides Bunge (Liliaceae). Biol. Pharm. Bull. 29, 2304-2306 (2006)   DOI   ScienceOn
8 Ohashi, H., Ido, Y., Imai, T., Yoshida, K., and Yasue, M., 4,4$^{\prime}$- Dihydroxychalcone from the heartwood of Chamaecyparis obtusa. Phytochemistry 27, 3993-3994 (1988)   DOI   ScienceOn
9 Duke, J.A., Bogenschutz-Godwin, M.J., duCellier, J., and Duke P.A.K., Handbook of Medicinal Herbs, 2th ed, CRC Press, New York, pp 27 (2002)
10 Jeong, S.J., Ahn, N.H., Kim, Y.C., Inagaki, M., Miyamoto, T., and Higuchi, R., Norlignans with hyaluronidase inhibitory activity from Anemarrhena asphodeloides. Planta Med. 65, 367-368 (1999)   DOI   ScienceOn
11 Hammami, S., Ben Jannet, H., Bergaoui, A., Ciavatta, L., Cimino, G., and Mighri, Z., Isolation and structure elucidation of a flavanone, a flavanone glycoside and vomifoliol from Echiochilon fruticosum growing in Tunisia. Molecules 9, 602-608 (2004)   DOI   ScienceOn
12 Mizuno, M., Kojima, H., Tanaka, T., Iinuma, M., Kimura, R., Min, Z.D., and Murata, H., Phenolic constituents from seeds of Coptis japonica var. dissecta. Phytochemistry 26, 2071-2074 (1987)   DOI   ScienceOn
13 Seidel, V., Bailleul, Fran$\c{c}$ois., and Waterman, P.G., (Rel)-1$\beta$,2$\alpha$-di-(2,4-dihydroxy-6-methoxybenzoyl)-3$\beta$,4$\alpha$-di-(4-methoxyphenyl)-cyclobutane and other flavonoids from the aerial parts of Goniothalamus gardneri and Goniothalamus thwaitesii. Phytochemistry 55, 439-446 (2000)   DOI   ScienceOn
14 Camarda, L., Merlini, L., and Nasini, G., Dragon's blood from Dracaena draco, structure of novel homoisoflavonoids. Heterocycles 20, 39-43 (1983)   DOI