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Antioxidant and antimicrobial constituents of Crucianella maritima L.  

Badr, Jihan M. (Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University)
Publication Information
Natural Product Sciences / v.14, no.4, 2008 , pp. 227-232 More about this Journal
Abstract
Phytochemical further investigation of the chloroform extract of the aerial parts of Crucianella maritima L. (Rubiaceae) growing in Egypt resulted in the isolation of a new anthraquinone; 3-formyl-1-hydroxy-2-methoxy anthraquinone (3) along with the four known compounds isolated for the first time from the genus Crucianella; alizarin-1-methyl ether (2), 1,4-dihydroxy-2-methoxy anthraquinone (5), 1, 3, 6-trihydroxy-2-methoxy anthraquinone (7) and the flavonol kaempferol (8), beside four known compounds previously isolated from the same plant. The structures of the isolated compounds were established based on different spectroscopic data including UV, IR, EIMS, 1D and 2D-NMR. Moreover, the antioxidant and antimicrobial activities of the isolated compounds were evaluated.
Keywords
Rubiaceae; Crucianella maritima L.; anthraquinones; spectroscopic techniques; antioxidant; antimicrobial activity;
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1 Jasril, N.H., Lajis, L.Y., Mooi, L.Y., Abdullah, M.A., Sukari, M.A., and Ali, A.M., Antitumour promoting and antioxidant activities of anthraquinones isolated from the cell suspension culture of M. elliptica. As. Pac. J. Mol. Biol. Biotechnol. 11, 3-7 (2003)
2 Kariba, R.M., Antimicrobial activity of H. parvifolium. Fitoterapia 73, 523-525 (2002)   DOI   ScienceOn
3 Lin, C.C., Ng, L.T., Yang J.J., and Hsu, Y.F., Anti-inflammatory and hepatoprotective activity of extracts of peh-hue-juwa- chi-cao in male rats. A.J.C.M. 30, 225-234 (2002)   DOI   ScienceOn
4 Pawlus, A.D., Su, B.N., Keller, W.J., and Kinghorn, A.D., An anthraquinone with potent quinine reductase-inducing activity and other constituents of the fruits of M. citrifolia (Noni). J. Nat. Prod. 68, 1720-1722 (2005)   DOI   ScienceOn
5 Yoshida, Y., Wang, M.Q., Liu, J.N., Shan, B.E., and Yamashita, U., Immunomodulating activity of Chinese medicinal herbs and O. diffusa in particular. Int. J. Immunopharmacol. 19, 359-370 (1997)   DOI   ScienceOn
6 Arpornsuwan , T. and Punjanon, T., Tumor cell-selective antiproliferative effect of the extract from M. citrifolia fruits. Phytother Res. 20, 515- 517 (2006)   DOI   ScienceOn
7 Koumaglo, K., Gbeassor, M., Nikabu, O., de Souza, and Werner, C.W., Effects of three compounds extracted from M. lucida on Plasmodium falciparum. Planta Med. 58, 533-534 (1992)   DOI   ScienceOn
8 El-Gamal, A.A., Takeya, K., Itokawa, H., Halim, A.F., Amer, M.M., Saad, H.E. A. and Awad, S.A., Anthraquinones from G. sinaicum. Phytochemistry 40, 245-251 (1995)   DOI   ScienceOn
9 Mavi, A., Terzi, Z., Ozgen, U., Yildirim, A., and Coskun, M., Antioxidant properties of some medicinal plants: P. ferulacea (Apiaceae), S. sempervivoides (Crassulaceae), M. neglecta (Malvaceae), C. taurica (Rubiaceae), R. pimpinellifolia (Rosaceae), G. verum subsp. verum (Rubiaceae), U. dioica (Urticaceae). Biol. Pharm. Bull. 27, 702-705 (2004)   DOI   ScienceOn
10 Gupta, S., Zhang, D., Yi, J., and Shao, J., Anticancer activities of O. diffusa. J. Herb. Pharmacother. 4, 21-33 (2004)   DOI
11 Koyama, J., Ogura, T., and Tagahara, K., Anthraquinones of G. spurium. Phytochemistry 33, 1540-1542 (1993)   DOI   ScienceOn
12 Mandal, S.C., Mohana Lakshmi, S., Ashok Kumar, C.K., Sur, T.K., and Boominathan, R., Evaluation of anti-inflammatory potential of P. indica Linn. leaf extract (family: Rubiaceae) in rats. Phytother. Res. 17, 817-820 (2003)   DOI   ScienceOn
13 Palu , A.K., Kim, A.H., West, B.J., Deng, S., Jensen, J., and White, L., The effects of M. citrifolia L. (noni) on the immune system: its molecular mechanisms of action. J Ethnopharmacol. 115, 502-506 (2008)   DOI   ScienceOn
14 Zhou, Z., Jiang, S.H., Zhu, D.Y., Lin, L.Z., and Cordell, G.A., Anthraquinones from K. valerianoides. Phytochemistry 36, 765-768 (1994)   DOI   ScienceOn
15 Andrade-Neto, V.F., Brandão, M.G., Stehmann, J.R., Oliveira, L.A., and Krettli, A.U., Antimalarial activity of Cinchona-like plants used to treat fever and malaria in Brazil. J Ethnopharmacol. 87, 253-256 (2003)   DOI   ScienceOn
16 Nijveldt, R.J., Nood, E., Hoorn, D.E.C., Boelens, P.G., Norren, K., and Leeuwen, P.A.M., Flavonoids: a review of probable mechanism of action and potent applications. Am. J. Clin. Nutr., 74, 418-425 (2001)   DOI   PUBMED
17 Kim, Y., Park, E.J., Kim, J., Kim, Y., Kim, S.R., and Kim, Y.Y., Neuroprotective constituents from H. diffusa. J. Nat. Prod. 64, 75-78 (2001)   DOI   ScienceOn
18 El-Lakany, A.M., Aboul-Ela, M.A., Abdel-Kader, M.S., Badr, J.M., Sabri, N.N., and Goher, Y., Anthraquinones with antibacterial activities from C. maritima L. growing in Egypt. Nat. Prod. Sciences, 10, 63-68 (2004)
19 Hamza, O.J.M., van den Bout-van den Beukel, C.J.P., Matee, M.I.N., Moshi, M.J., Mikx, F.H.M., Selemani, H.O., Mbwambo, Z.H., and Verweij, P.E., Antifungal activity of some Tanzanian plants used traditionally for the treatment of fungal infections. J Ethnopharmacol. 108, 124-132 (2006)   DOI   ScienceOn
20 Morimoto, M., Tanimoto, K., Sakatani, A., and Komai, K., Antifeedant activity of an anthraquinone aldehyde in G. aparine L. against Spodoptera litura F. Phytochemistry 60, 163-166 (2002)   DOI   ScienceOn
21 Jose, G.A., Omar, M.C., Fernando, B., Robert, B., Jose, P.C., Andres, N., and Rachel, M., Antidiabetic properties of selected Mexican copalchis of the Rubiaceae family. Phytochemistry 68, 2087-2095 (2007)   DOI   ScienceOn
22 Kumar, B., Vijayakumar, M., Govindarajan, R., and Pushpangadan, P., Ethnopharmacological approaches to wound healing-exploring medicinal plants of India. J Ethnopharmacol. 114, 103-113 (2007)   DOI   ScienceOn
23 Wang, M.Y., Nowicki, D., Anderson, G., Jensen, J., and West, B., Liver Protective Effects of M. citrifolia (Noni). Plant Foods Hum Nutr. 63, 59-63 (2008)   DOI
24 Kalyoncu, F., Cetin, B., and Saglam, H., Antimicrobial activity of common madder (R. tinctorum L.). Phytother Res. 20, 490-492 (2006)   DOI   ScienceOn
25 Lin, C.C., Ng, L.T., and Yang J.J., Antioxidant activity of extracts of pehhue- juwa- chi-cao in a cell free system. A.J.C.M. 32, 339-349 (2004)   DOI   ScienceOn
26 Takamatsu, S., Hodges, T.W., Rajbhandari, I., Gerwick, W.H., Hamann, M.T., and Nagle, D.G., Marine natural products as novel antioxidant prototypes. J. Nat. Prod, 66, 605-608 (2003)   DOI   ScienceOn
27 Manojlovic, N.T., Solujic, S., Sukdolak, S., and Milosev, M., Antifungal activity of R. tinctorum, Rhamnus frangula and Caloplaca cerina. Fitoterapia 76, 244-246 (2005)   DOI   ScienceOn
28 Kuiper, J. and Labadie, R.P., Polyploid complexes within the genus Galium. Planta Med. 42, 390-399 (1981)   DOI