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http://dx.doi.org/10.3746/jfn.2002.7.2.119

A Quinolone Alkaloid, from the Aleurone Layer of Oryza sativa cv. Mihyangbyo, Inhibits Growth of Cultured Human Leukemia Cell  

Chung, Ha-Sook (Department of Food and Nutrition, Duksung Women′s University)
Publication Information
Preventive Nutrition and Food Science / v.7, no.2, 2002 , pp. 119-122 More about this Journal
Abstract
Oryza sativa cv. Mihyangbyo is one of several recently developed varieties of rice; characterized by high levels of aromatic components, which may increase its sensory and nutritional properties. In conjunction with our continuing investigation of bioactive components of improved grain varieties, a quinolone alkaloid was isolated from the n-butanol soluble fraction of the aleurone layer of Oryza sativa cv. Mihyangbyo (Gramineae) through activity-guided fractionation and isolation. The compound exhibited moderate antineoplastic activity in a human leukemia cell line (U937) with an $IC_{50}$/ value of 118.1 ug/mL, based on the MTT(3-[4, 5]dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) cell proliferation assay. The chemical structure of the functional compound was determined, based on physical and spectroscopic characteristics.
Keywords
Oryza sativa cv. Mihyangbyo; Gramineae; alkaloid; 4-carbomethoxy-6-methoxy-2-quinolone; human leukemia cell; MTT assay; 2D NMR;
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