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http://dx.doi.org/10.5713/ajas.15.0608

Genome-association analysis of Korean Holstein milk traits using genomic estimated breeding value  

Shin, Donghyun (Department of Agricultural Biotechnology, Animal Biotechnology, and Research Institute for Agriculture and Life Sciences, Seoul National University)
Lee, Chul (Interdisciplinary Program in Bioinformatics, Seoul National University)
Park, Kyoung-Do (The Animal Molecular Genetics & Breeding Center, Chonbuk National University)
Kim, Heebal (Department of Agricultural Biotechnology, Animal Biotechnology, and Research Institute for Agriculture and Life Sciences, Seoul National University)
Cho, Kwang-hyeon (Division of Animal Breeding and Genetics, National Institute of Animal Science, Rural Development Administration)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.30, no.3, 2017 , pp. 309-319 More about this Journal
Abstract
Objective: Holsteins are known as the world's highest-milk producing dairy cattle. The purpose of this study was to identify genetic regions strongly associated with milk traits (milk production, fat, and protein) using Korean Holstein data. Methods: This study was performed using single nucleotide polymorphism (SNP) chip data (Illumina BovineSNP50 Beadchip) of 911 Korean Holstein individuals. We inferred each genomic estimated breeding values based on best linear unbiased prediction (BLUP) and ridge regression using BLUPF90 and R. We then performed a genome-wide association study and identified genetic regions related to milk traits. Results: We identified 9, 6, and 17 significant genetic regions related to milk production, fat and protein, respectively. These genes are newly reported in the genetic association with milk traits of Holstein. Conclusion: This study complements a recent Holstein genome-wide association studies that identified other SNPs and genes as the most significant variants. These results will help to expand the knowledge of the polygenic nature of milk production in Holsteins.
Keywords
Korean Holstein; Genome-wide Association Studies (GWAS); Milk Production; Milk Fat; Milk Protein;
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Times Cited By KSCI : 3  (Citation Analysis)
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