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http://dx.doi.org/10.5713/ajas.15.0553

Evaluation of Relative Bioavailability of 25-Hydroxycholecalciferol to Cholecalciferol for Broiler Chickens  

Han, J.C. (Department of Animal Science, College of Life Science, Shangqiu Normal University)
Chen, G.H. (Department of Animal Science, College of Life Science, Shangqiu Normal University)
Wang, J.G. (Department of Animal Science, College of Life Science, Shangqiu Normal University)
Zhang, J.L. (Department of Animal Science, College of Life Science, Shangqiu Normal University)
Qu, H.X. (Department of Animal Science, College of Life Science, Shangqiu Normal University)
Zhang, C.M. (Department of Animal Science, College of Life Science, Shangqiu Normal University)
Yan, Y.F. (Department of Animal Science, College of Life Science, Shangqiu Normal University)
Cheng, Y.H. (Department of Biotechnology and Animal Science, National Ilan University)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.29, no.8, 2016 , pp. 1145-1151 More about this Journal
Abstract
This study was conducted to evaluate the relative bioavailability (RBV) of 25-hydroxycholecalciferol (25-OH-$D_3$) to cholecalciferol (vitamin $D_3$) in 1- to 21-d-old broiler chickens fed with calcium (Ca)- and phosphorus (P)-deficient diets. On the day of hatch, 450 female Ross 308 broiler chickens were assigned to nine treatments, with five replicates of ten birds each. The basal diet contained 0.50% Ca and 0.25% non-phytate phosphorus (NPP) and was not supplemented with vitamin D. Vitamin $D_3$ was fed at 0, 2.5, 5.0, 10.0, and $20.0{\mu}g/kg$, and 25-OH-$D_3$ was fed at 1.25, 2.5, 5.0, and $10.0{\mu}g/kg$. The RBV of 25-OH-$D_3$ was determined using vitamin $D_3$ as the standard source by the slope ratio method. Vitamin $D_3$ and 25-OH-$D_3$ intake was used as the independent variable for regression analysis. The linear relationships between the level of vitamin $D_3$ or 25-OH-$D_3$ and body weight gain (BWG) and the weight, length, ash weight, and the percentage of ash, Ca, and P in femur, tibia, and metatarsus of broiler chickens were observed. Using BWG as the criterion, the RBV value of 25-OH-$D_3$ to vitamin $D_3$ was 1.85. Using the mineralization of the femur, tibia, and metatarsus as criteria, the RBV of 25-OH-$D_3$ to vitamin $D_3$ ranged from 1.82 to 2.45, 1.86 to 2.52, and 1.65 to 2.05, respectively. These data indicate that 25-OH-$D_3$ is approximately 2.03 times as active as vitamin $D_3$ in promoting growth performance and bone mineralization in broiler chicken diets.
Keywords
25-Hydroxycholecalciferol; Cholecalciferol; Relative Bioavailability; Growth; Bone; Broiler Chicken;
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