Browse > Article
http://dx.doi.org/10.5713/ajas.2002.1121

Dietary Protein Restriction on Growth and Immuno-biochemical Response of Crossbred Calves during Post-ruminant Phase of Life  

Sahoo, A. (Center of Advance Studies in Animal Nutrition, Indian Veterinary Research Institute)
Mishra, S.C. (Center of Advance Studies in Animal Nutrition, Indian Veterinary Research Institute)
Pathak, N.N. (Center of Advance Studies in Animal Nutrition, Indian Veterinary Research Institute)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.15, no.8, 2002 , pp. 1121-1127 More about this Journal
Abstract
Sixteen crossbred (Bos indicus${\times}$Bos taurus) calves were randomly distributed in two groups (NP and LP) of eight calves each to study the effect of restricted (75%) protein supply on growth and immuno-biochemical response as an indicator of production and health of under-nourished animals during 3 to 9 months of age. The normal requirement of protein was provided to group NP and a less of 25% to group LP through calculated amount of concentrate and roughage in their daily ration. Assessment was made for weekly change in live weight, periodic alteration in blood metabolites and immunological status at six months of age in calves. An initial (during 3 to 6 months of age) depression (p<0.05) in growth was seen in low protein fed group (LP) compared to NP, which became non-significant in the later period of life (6 to 9 months of age). There was no significant effect on haemoglobin, total protein, albumin and globulin concentration except that of urea, which was decreased significantly (p<0.05) in animals fed on low protein diet ($19.83{\pm}1.25$ vs $25.93{\pm}1.29mg/dl$). The treatment effect that was seen in different periods of life was not uniform for other parameters except for urea, which showed a regular depression in LP compared to NP. The assessment of immunological status by indirect haemagglutination (IHA) test against Pasteurella multocida (P52 strain) was considerably (p<0.05) reduced in animals on LP ration compared to those on NP. It is thus argued that with poor nutrition (low protein) and state of compromised immunological response the production and health of the animals will be adversely affected.
Keywords
Crossbred Calves; Protein Restriction; Growth; Blood Profile; Immunity;
Citations & Related Records

Times Cited By Web Of Science : 3  (Related Records In Web of Science)
Times Cited By SCOPUS : 3
연도 인용수 순위
1 Chandra, R. K. 1999. Nutrition and immunology: from the clinic to cellular biology and back again. Proc. Nutr. Soc. 58:681-683.   DOI   PUBMED
2 Cooper, W. C., R. A. Good and T. Mariani. 1974. Effect of protein insufficiency on immune responsiveness. Am J. Clin. Nutr. 27:647-664.
3 Jahoor, F., M. Desai, D. N. Herndon and R. R. Wolfe. 1988. Dynamics of the protein metabolic response to burn injury. Metabolism. 37:330-337.   DOI   ScienceOn
4 Jeejeebhoy, K. N., A. Bruce-Robertson, J. Ho and U. Sodtke. 1973. In: Protein Turnover. CIBA Foundation Symposium No. 9, Associated Scientific Publishers, Amsterdam.
5 USDA. 2002. Production Estimate and Crop Assessment Division, FAS, US Department of Agriculture.
6 Woodward, L. E., W. P. Eckblad, D. P. Olson, R. C. Bull and D. O. Everson. 1980. Serum complement activity of protein-energy malnourished beef cows. Am. J. Vet. Res. 41:1546-1548.
7 Fleck, A., F. Hawker, P. I. Wallace, G. Raines, J. Trotters, I. M. Ledingham and K. C. Calma. 1985. Increased vascular permeability: A major cause of hypoalbuminaemia in diseased and injury. Lancet. 1:781-784.   DOI   ScienceOn
8 Gornall, A. G., C. J. Bardawill and M. M. David. 1949. Determination of serum proteins bymeans of the biuret reaction. J. Biol. Chem. 177:751-766.
9 NRC. 2001. Nutrient Requirements of Dairy Cattle, 7th edn. National Research Council, National Academy of Science, Washington, DC.
10 Pugliese, M. T. 1990. Endocrine function adaptations in undernutrition. Wld Rev. Nutr. Ditet. 62:186-211.   PUBMED
11 cc 1958. Nutritional deficiencies. In: Diseases of Swine (Ed. H. W. Dunne). Iowa State University Press, Ames. pp. 627-648.
12 Millward, D. J., G. M. Price, P. J. H. Pacy and D. Halliday. 1991. Whole body protein and amino acid turnover in man: what can we measure with confidence? Proc. Nutr. Soc. 50:197-216.   DOI   ScienceOn
13 Charland, S., L. D. Bartlett and M. H. Torosian. 1994. Effect of protein-calorie malnutrition on methotrexate pharmocokinetics. J. Parentl Entl Nutr. 18:45-49.   DOI
14 Reddy, P. G. and R. A. Frey. 1993. Nutritional modulation of immunity in domestic food animals. In: Immunomodulation in Domestic Animals, Vol. 35 (Ed. B. Frank and C. Bernard). Academic Press, Inc., London, pp. 225-258.
15 Tizzard, I. 1992. Secondary immunological defects. In: Veterinary Immunology: An Introduction, 4th edn (Ed. W. B. Saunders). Co., Philadelphia, p. 443.
16 Fiske, R. A. and L. G. Adams. 1985. Immune responsiveness and lymphoreticular morphology in cattle fed hypo and hyper alimentative diets. Vet. Immunol. Immunopath. 8:225-244.   DOI   ScienceOn
17 Hirschfield, J. and F. Kern, Jr. 1969. Protein starvation and the small intestine. III. Inorporation of orally and intraperitoneally administered I-leucine 4,5-H3 into intestinal mucosal protein of protein-deprived rats. J. Clin. Invest. 48:1224-1229.   DOI
18 Oser, B. L. 1971. Blood and other body fluids. In: Hawk's Physiological Chemistry, 14th edn, Tata McGraw-Hill Publ. Co. Ltd., New Delhi. pp. 321-367.
19 Coles, E. H. 1980. Veterinary Clinical pathology, 3rd edn. W.B. Saunders, Philadelphia.
20 Satter, L. D. and R. E. Roffler. 1977. Influence of nitrogen and carbohydrate inputs on rumen fermentation. In: Recent Advances in Animal Nutrition-1977 (Ed. W. Haresign and D. Lewis). Butterworth Publ. London, pp. 25-49.
21 Bars, H. Le. 1967. The endogenous urea cycle of the ruminant. In: Urea as a Protein Supplement (Ed. M. H. Briggs). Pregmon Press, London. pp. 155-171.
22 Clowes, G. H. A., H. T. Randall and C. J. Cha. 1980. Amino acid and energy metabolism in septic and traumatized patients. J. Paren. Enter. Nutr. 4:195-205.   DOI
23 Doumas, B. T., W. A. Watson and H. G. Biggs. 1971. Albumin standards and the measurement of serum albumin with bromocresol green. Clin. Chim. Acta. 31:87-96.   DOI   ScienceOn
24 Van Soest, P. J., J. B. Robertson and B. A. Lewis. 1991. Methods of dietary fiber, neutral detergent fiber and non-starch polysaccharides in relation to animal nutrition. J. Dairy Sci. 74:3583-3597.   DOI   ScienceOn
25 AOAC. 1990. Official Methods of Analysis, 14th edn. Association of Official Analytical Chemists. Washington, DC.
26 McGillivray, H. 1967. Immunological response of the pig as affected by amino acid nutrition. Ph.D. Dessertation, University of Illinois, Urbana-Campaign.
27 Sheffy, B. E. and A. J. Williams. 1982. Nutrition and immune response. J. Am. Vet. Med. Assoc. 180:1073-1076.
28 Golden, M. H. N., J. C. Waterlow and D. Picou. 1977. Protein turnover, synthesis and breakdown before and after recovery from protein-energy malnutrition. Clin. Sci. 53:473-477.
29 Beisel, W. R. 1984. Metabolic effects of infection. Prog. Food Nutr. Sci. 8:43-75.   PUBMED
30 Rahmatullah, M. and T. R. C. Boyde. 1980. An improvement in determination of urea using diacetyl monoxime method with and without deproteinization. Clin. Chim. Acta 107:3-9.   DOI   ScienceOn
31 Snedecor, G. W. and W. G. Cochran. 1989. Statistical Methods, 8th edn, Iowa State Univ. Press, Ames, Iowa.
32 Fleck, A. 1989. Clinical and nutritional aspects of changes in acute-phase proteins during inflammation. Proc. Nutr. Soc. 48:347-354.   DOI   ScienceOn
33 Millward, D. J., P. J. Garlick, W. P. T. James, P. M. Sender and J. C. Waterlow. 1976. Protein turnover. In: Protein Metabolism and Nutrition (Ed. D. J. A. Cole, K. N. Boorman, P. J. Buttery, D. Lewis, R. J. Neale and H. Swan). Butterworths, London. pp. 49-69.
34 Jahoor, F., L. Wykes, M. Del Rosario, M. Frazer and P. J. Reeds. 1999. Chronicprotein undernutrition and an acute inflamatory stimulus elicit different protein kinetic responses in plasma but not in muscle of piglets. J. Nutr. 129:693-699.
35 Sawada, T., R. B. Rimler and K. R. Rhoades. 1982. Indirect H.A. test that uses glutaraldehyde-fixed sheep erythrocytes sensitized with extract antigens for detection of pasteurella antibody. J. Clin. Microbiol. 82:752-756.
36 Klasing, K. C. 1988. Nutritional aspects of leukocytic cytokines. J. Nutr. 118:1436-1446.   PUBMED